Collagen/nano-sized β-tricalcium phosphate conduits combined with collagen filaments and nerve growth factor promote facial nerve regeneration in miniature swine: an in vivo study

2019 ◽  
Vol 128 (5) ◽  
pp. 472-478 ◽  
Author(s):  
Zhen Zhang ◽  
Xiang Li ◽  
Zheyi Li ◽  
Yuxing Bai ◽  
Guiqing Liao ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Facial Nerve ◽  
Nerve Regeneration ◽  
Tricalcium Phosphate ◽  
In Vivo Study ◽  
Miniature Swine ◽  
Nerve Growth

Comparison of Rabbit Facial Nerve Regeneration in Nerve Growth Factor-Containing Silastic Tubes to Autologous Cable Grafts

1994 ◽  
pp. 440-440
Author(s):  
J. G. Spector ◽  
P. Lee ◽  
A. Derby ◽  
G. Frierdich ◽  
G. R. Neises ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Facial Nerve ◽  
Nerve Regeneration ◽  
Nerve Growth

Facilitation of facial nerve regeneration using chitosan-β-glycerophosphate-nerve growth factor hydrogel

2016 ◽  
Vol 136 (6) ◽  
pp. 585-591 ◽  
Author(s):  
Xiuhua Chao ◽  
Lei Xu ◽  
Jianfeng Li ◽  
Yuechen Han ◽  
Xiaofei Li ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Facial Nerve ◽  
Nerve Regeneration ◽  
Nerve Growth

Nerve Growth Factor: Morphological and Morphometric Findings on Facial Nerve Regeneration in the Rabbit

1994 ◽  
pp. 407-409
Author(s):  
M. J. Bernardo ◽  
P. Ablanedo ◽  
C. Suarez ◽  
M. Alvarez-Uria ◽  
J. L. Llorente
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Facial Nerve ◽  
Nerve Regeneration ◽  
Nerve Growth

Comparison of Rabbit Facial Nerve Regeneration in Nerve Growth Factor-Containing Silicone Tubes to that in Autologous Neural Grafts

1995 ◽  
Vol 104 (11) ◽  
pp. 875-885 ◽  
Author(s):  
J. Gershon Spector ◽  
Albert Derby ◽  
Patty Lee ◽  
Dikla G. Roufa
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Facial Nerve ◽  
Nerve Regeneration ◽  
Myelinated Axons ◽  
Nerve Growth ◽  
Nerve Grafts ◽  
Myelinated Fibers ◽  
Significant Difference ◽  
Cyt C

Previous reports suggest that nerve growth factor (NGF) enhanced nerve regeneration in rabbit facial nerves. We compared rabbit facial nerve regeneration in 10-mm silicone tubes prefilled with NGF or cytochrome C (Cyt C), bridging an 8-mm nerve gap, to regeneration of 8-mm autologous nerve grafts. Three weeks following implantation, NGF-treated regenerates exhibited a more mature fascicular organization and more extensive neovascularization than Cyt C-treated controls. Morphometric analysis at the middle of the tube of 3- and 5-week regenerates revealed no significant difference in the mean number of myelinated or unmyelinated axons between NGF- and Cyt C-treated implants. However, when the numbers of myelinated fibers in 5-week regenerates were compared to those in their respective preoperative controls, NGF-treated regenerates had recovered a significantly greater percentage of myelinated axons than Cyt C-treated implants (46% versus 18%, respectively). The number of regenerating myelinated axons in the autologous nerve grafts at 5 weeks was significantly greater than the number of myelinated axons in the silicone tubes. However, in the nerve grafts the majority of the axons were found in the extrafascicular connective tissue (66%). The majority of these myelinated fibers did not find their way into the distal nerve stump. Thus, although the number of regenerating myelinated axons within the nerve grafts is greater than that of axons within silicone tube implants, functional recovery of autologous nerve graft repairs may not be superior to that of intubational repairs.

Inducible Nerve Growth Factor Delivery for Peripheral Nerve Regeneration In Vivo

2010 ◽  
Vol 126 (6) ◽  
pp. 1874-1889 ◽  
Author(s):  
Thomas Scholz ◽  
Jason M. Rogers ◽  
Alisa Krichevsky ◽  
Sanjay Dhar ◽  
Gregory R. D. Evans
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Growth Factor Delivery ◽  
Nerve Growth

Nerve Growth Factor Enhances Nerve Regeneration through Fibronectin Grafts

1996 ◽  
Vol 21 (4) ◽  
pp. 514-522 ◽  
Author(s):  
I. H. WHITWORTH ◽  
R. A. BROWN ◽  
C. J. DORÉ ◽  
P. ANAND ◽  
C. J. GREEN ◽  
...  
Keyword(s):  
Image Analysis ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Schwann Cell ◽  
Nerve Regeneration ◽  
Axonal Regeneration ◽  
Cell Regeneration ◽  
Nerve Growth ◽  
Computerized Image Analysis ◽  
Immunohistochemical Techniques

Soluble fibronectin and nerve growth factor (NGF) promote axonal regeneration when placed in silicone tubes. We investigated the ability of orientated fibronectin mats to bind and release bioactive NGF and the possibility of augmenting axonal regeneration following axotomy by using fibronectin conduits impregnated with NGF. The release of NGF was quantified using a fluorometric ELISA and bioactivity confirmed with a neuronal culture bioassay. Immunohistochemical techniques and computerized image analysis were used to assess the rate and volume of axonal and Schwann cell regeneration. The delivery of NGF to the site of injury produced an increase in the rate ( P≤0.007) and volume ( P≤0.004) of both axonal and Schwann cell regeneration when compared to conduits of plain fibronectin. We conclude that the local delivery of NGF by impregnated fibronectin conduits enhances axonal regeneration.

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