TONGUE NECROSIS: A RARE AND LATE ORAL COMPLICATION TO RADIOTHERAPY IN HEAD AND NECK

2017 ◽  
Vol 124 (2) ◽  
pp. e52
Author(s):  
ANTHONY BENITES CONDEZO ◽  
CAMILA LOPES CARDOSO ◽  
SÉRGIO ROCHA ARAUJO ◽  
DANIEL HENRIQUE KOGA ◽  
MARCOS MARTINS CURI
Keyword(s):  
Head And Neck ◽  
Oral Complication ◽  
Tongue Necrosis

scholarly journals Etiopathogenesis of Trismus in Patients With Head and Neck Cancer: An Exploratory Literature Review

2020 ◽  
Vol 13 (3) ◽  
pp. 219-225
Author(s):  
Radhu Raj ◽  
Krishnakumar Thankappan ◽  
Chandrasekhar Janakiram ◽  
Subramania Iyer ◽  
Anil Mathew
Keyword(s):  
Head And Neck Cancer ◽  
Cohort Studies ◽  
Head And Neck ◽  
Neck Cancer ◽  
Infratemporal Fossa ◽  
Tumor Ingrowth ◽  
Retrospective Cohort Studies ◽  
Radiation Induced ◽  
Randomized Control ◽  
Oral Complication

Trismus refers to a person’s inability to normally open his or her mouth. Trismus can occur as a symptom due to tumor ingrowth or it can occur postsurgical following the treatment for head and neck cancer. Radiation-induced trismus is also a relatively common oral complication. This review aimed at reviewing the etiopathogenesis of trismus in patients with head and neck cancer. Of the 16 publications included after final screening, of which one was a nonrandomized control trial, one a randomized control trial, 6 prospective cohort studies, and 8 retrospective cohort studies. Among them, 6 articles addressed the possible mechanism for trismus related to tumor ingrowth, 8 articles suggested the likely reason for trismus in patients who had undergone radiation therapy and 2 articles addressed the postsurgical cause for trismus. This review highlights the possible involvement of infratemporal fossa as a predetermining factor for developing trismus related to tumor extension. The molecular mechanism of radiation-induced fibrosis is well studied in the literature.

Delayed tongue necrosis simultaneous with bilateral osteoradionecrosis of the jaw secondary to head and neck irradiation

2017 ◽  
Vol 123 (2) ◽  
pp. e28-e32 ◽  
Author(s):  
Marcos Martins Curi ◽  
Camila Lopes Cardoso ◽  
Anthony Froy Condezo Benites ◽  
Patrícia Martins Bueno
Keyword(s):  
Head And Neck ◽  
Neck Irradiation ◽  
Head And Neck Irradiation ◽  
Tongue Necrosis

Copper-dependent ATP7B up-regulation drives the resistance of TMEM16A-overexpressing head-and-neck cancer models to platinum toxicity

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov
Keyword(s):  
Oxidative Stress ◽  
Head And Neck ◽  
Transcriptional Activation ◽  
Platinum Resistance ◽  
Mrna Levels ◽  
Strong Positive Correlation ◽  
Platinum Compounds ◽  
Copper Chelation ◽  
Novel Approach ◽  
Cancer Models

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.

Intubation during manual in-line stabilisation of the head and neck

Anaesthesia ◽  
2000 ◽  
Vol 55 (8) ◽  
pp. 814-814 ◽  
Author(s):  
R. M. Dravid ◽  
M. Popat
Keyword(s):  
Head And Neck

Smoking correlates with the presence of p53 mutations in squamous cell carcinomas of the head and neck (SCCHN)

1998 ◽  
Vol 23 (3) ◽  
pp. 268-269
Author(s):  
Liloglou ◽  
Scholes ◽  
Spandidos ◽  
Jones ◽  
Vaughan ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
P53 Mutations

Nutritional status as a prognostic factor in advanced head and neck cancer

1998 ◽  
Vol 23 (4) ◽  
pp. 376-376
Author(s):  
Quak ◽  
Van Bokhorst ◽  
Klop ◽  
Van Leeuwen ◽  
Snow
Keyword(s):  
Head And Neck Cancer ◽  
Prognostic Factor ◽  
Nutritional Status ◽  
Head And Neck ◽  
Neck Cancer ◽  
Advanced Head
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