Depletion of Dendritic Cells in Cervical Lymph Nodes and Palatine Tonsils of HIV-Positive Patients

2015 ◽  
Vol 120 (2) ◽  
pp. e93
Author(s):  
BIANCA CARLA BIANCO ◽  
THAIS MAUAD ◽  
LUCIANA SCHULTZ ◽  
ANA LÚCIA NORONHA FRANCISCO ◽  
LUIZ PAULO KOWALSKI ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lymph Nodes ◽  
Hiv Positive ◽  
Cervical Lymph Nodes ◽  
Palatine Tonsils

Decreased CD1a+, CD83+and factor XIIIa+dendritic cells in cervical lymph nodes and palatine tonsils of AIDS patients

2013 ◽  
Vol 64 (2) ◽  
pp. 234-241 ◽  
Author(s):  
Rogério Gondak ◽  
Thais Mauad ◽  
Luciana Schultz ◽  
Fernando Soares ◽  
Luiz P Kowalski ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Lymph Nodes ◽  
Factor Xiiia ◽  
Aids Patients ◽  
Cervical Lymph Nodes ◽  
Palatine Tonsils

How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes

Blood ◽  
2006 ◽  
Vol 107 (2) ◽  
pp. 806-812 ◽  
Author(s):  
Eric Hatterer ◽  
Nathalie Davoust ◽  
Marianne Didier-Bazes ◽  
Carine Vuaillat ◽  
Christophe Malcus ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Dendritic Cells ◽  
Lymph Nodes ◽  
B Cell ◽  
Subventricular Zone ◽  
Lymphatic Vessels ◽  
Brain Parenchyma ◽  
Cervical Lymph Nodes ◽  
The Central Nervous System ◽  
Anatomic Feature

AbstractThe lack of draining lymphatic vessels in the central nervous system (CNS) contributes to the so-called “CNS immune privilege.” However, despite such a unique anatomic feature, dendritic cells (DCs) are able to migrate from the CNS to cervical lymph nodes through a yet unknown pathway. In this report, labeled bone marrow-derived myeloid DCs were injected stereotaxically into the cerebrospinal fluid (CSF) or brain parenchyma of normal rats. We found that DCs injected within brain parenchyma migrate little from their site of injection and do not reach cervical lymph nodes. In contrast, intra-CSF-injected DCs either reach cervical lymph nodes or, for a minority of them, infiltrate the subventricular zone, where neural stem cells reside. Surprisingly, DCs that reach cervical lymph nodes preferentially target B-cell follicles rather than T-cell-rich areas. This report sheds a new light on the specific role exerted by CSF-infiltrating DCs in the control of CNS-targeted immune responses. (Blood. 2006; 107:806-812)

Expression of dendritic cell phenotypic antigens in cervical lymph nodes of patients with hypopharyngeal and laryngeal carcinoma

2009 ◽  
Vol 123 (S31) ◽  
pp. 5-10 ◽  
Author(s):  
X Li ◽  
Y Takahashi ◽  
K Sakamoto ◽  
T Nakashima
Keyword(s):  
Dendritic Cells ◽  
Dendritic Cell ◽  
Lymph Nodes ◽  
Laryngeal Carcinoma ◽  
Hypopharyngeal Carcinoma ◽  
Cervical Lymph Nodes ◽  
Metastatic Lymph Nodes ◽  
Metastatic Lymph ◽  
Significant Difference ◽  
Cluster Of Differentiation

AbstractBackground:The purpose of this study was to assess the presence of dendritic cell phenotypic antigens in the cervical lymph nodes of patients with hypopharyngeal and laryngeal carcinoma, and to assess the significance of such antigens in the tumour immune reaction.Methods:Immunohistochemical staining of cervical lymph nodes was performed using antibodies against cell surface markers such as S-100 protein and cluster of differentiation 1a and 83 glycoproteins. Two hundred and seventy-four cervical lymph nodes obtained at surgery from 37 patients with hypopharyngeal carcinoma and 31 patients with laryngeal carcinoma were thus evaluated.Results:The number of dendritic cells positive for each phenotypic antigen was significantly greater in non-metastatic lymph nodes than in metastatic lymph nodes. In the metastatic lymph nodes, cluster of differentiation 1a glycoprotein positive dendritic cells were predominantly detected in the cancer ‘nest’, whereas mature dendritic cells staining for cluster of differentiation 83 glycoprotein were prominent in the peritumour area. In the metastatic lymph nodes, in contrast to the cluster of differentiation 1a glycoprotein positive dendritic cells, the degree of infiltration of cluster of differentiation 83 glycoprotein positive dendritic cells was significantly higher in the peritumour area than in the cancer nest. There was a significant difference in survival status, comparing patients with different degrees of dendritic cell infiltration for each type of phenotypic antigen.Conclusions:Dendritic cells may play different roles in tumour immunity against hypopharyngeal and laryngeal carcinoma. The phenotypic antigens of dendritic cells may thus constitute important indices with which to predict the prognosis of patients with hypopharyngeal and laryngeal carcinoma.

scholarly journals Cerebrospinal Fluid Dendritic Cells Infiltrate the Brain Parenchyma and Target the Cervical Lymph Nodes under Neuroinflammatory Conditions

PLoS ONE ◽  
2008 ◽  
Vol 3 (10) ◽  
pp. e3321 ◽  
Author(s):  
Eric Hatterer ◽  
Monique Touret ◽  
Marie-Françoise Belin ◽  
Jérôme Honnorat ◽  
Serge Nataf
Keyword(s):  
Cerebrospinal Fluid ◽  
Dendritic Cells ◽  
Lymph Nodes ◽  
Brain Parenchyma ◽  
Cervical Lymph Nodes ◽  
The Brain

scholarly journals Generation of Th17 cells in response to intranasal infection requires TGF-β1 from dendritic cells and IL-6 from CD301b+ dendritic cells

2015 ◽  
Vol 112 (41) ◽  
pp. 12782-12787 ◽  
Author(s):  
Jonathan L. Linehan ◽  
Thamotharampillai Dileepan ◽  
Sakeen W. Kashem ◽  
Daniel H. Kaplan ◽  
Patrick Cleary ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Lymph Nodes ◽  
Mhc Class Ii ◽  
Th17 Cells ◽  
Cell Subset ◽  
Class Ii ◽  
Dendritic Cell Subset ◽  
Cervical Lymph Nodes ◽  
Tgf Β1

Intranasal (i.n.) infections preferentially generate Th17 cells. We explored the basis for this anatomic preference by tracking polyclonal CD4+ T cells specific for an MHC class II-bound peptide from the mucosal pathogen Streptococcus pyogenes. S. pyogenes MHC class II-bound peptide-specific CD4+ T cells were first activated in the cervical lymph nodes following i.n. inoculation and then differentiated into Th17 cells. S. pyogenes-induced Th17 formation depended on TGF-β1 from dendritic cells and IL-6 from a CD301b+ dendritic cell subset located in the cervical lymph nodes but not the spleen. Thus, the tendency of i.n. infection to induce Th17 cells is related to cytokine production by specialized dendritic cells that drain this site.

In situ demonstration of migration of dendritic cells released from rat small intestine to mesenteric lymph nodes

2001 ◽  
Vol 120 (5) ◽  
pp. A183-A183
Author(s):  
H KOBAYASHI ◽  
H NAGATA ◽  
S MIURA ◽  
T AZUMA ◽  
H SUZUKI ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Small Intestine ◽  
Lymph Nodes ◽  
Rat Small Intestine ◽  
Mesenteric Lymph Nodes ◽  
Mesenteric Lymph

Benign thyroid inclusions in cervical lymph nodes

JAMA ◽  
1965 ◽  
Vol 194 (1) ◽  
pp. 1-4 ◽  
Author(s):  
A. D. Nicastri
Keyword(s):  
Lymph Nodes ◽  
Cervical Lymph Nodes ◽  
Benign Thyroid
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