Clear Cell Odontogenic Carcinoma, Three Cases: Clinical, Radiographic and Molecular Features of This Rare Odontogenic Tumor

2015 ◽  
Vol 119 (3) ◽  
pp. e154
Author(s):  
Aaron E. Yancoskie ◽  
Gianfranco Favia ◽  
John E. Fantasia
Keyword(s):  
Clear Cell ◽  
Odontogenic Tumor ◽  
Molecular Features ◽  
Clear Cell Odontogenic Carcinoma ◽  
Odontogenic Carcinoma

Clear Cell Odontogenic Carcinoma

2001 ◽  
Vol 125 (12) ◽  
pp. 1566-1571
Author(s):  
Tie-Jun Li ◽  
Shi-Feng Yu ◽  
Yan Gao ◽  
En-Bo Wang
Keyword(s):  
Clear Cell ◽  
S100 Protein ◽  
Odontogenic Tumor ◽  
Cytokeratin 19 ◽  
Low Grade ◽  
Clear Cells ◽  
Clear Cell Odontogenic Carcinoma ◽  
Eosinophilic Cytoplasm ◽  
Odontogenic Carcinoma

Abstract Context.—Odontogenic tumor composed predominantly of clear cells is a rare neoplasm of the jaws that was initially designated as clear cell odontogenic tumor. Subsequent reports in the literature, however, all have indicated that this tumor exhibits an aggressive behavior characterized by infiltrative local growth, recurrence, or metastases. Objective.—To ascertain the clinicomorphologic features and biologic behavior of this tumor group, we present 5 additional cases using the term clear cell odontogenic carcinoma. Design.—Histologic and immunohistochemical examinations were performed on clear cell odontogenic carcinomas from 5 patients. Clinical and follow-up data were recorded, and the literature was reviewed. Results.—The patients were 1 man and 4 women with an average age of 42.4 years at diagnosis. Three tumors occurred in the mandible and the other 2 in the maxilla. Four of the 5 cases occurred in the anterior or premolar areas of the jaws, appearing as poorly marginated radiolucencies. All cases consisted of islands and sheets of large clear cells and small basaloid cells with scanty eosinophilic cytoplasm, which were separated by thin, mature, fibrous septae. The tumors were unencapsulated and showed aggressive infiltration of the surrounding muscle and perineural tissues. Most of the clear cells contained cytoplasmic glycogen. Immunocytochemically, the tumor cells were positive for pan-keratin, cytokeratin 19, and epithelial membrane antigen, but were negative for vimentin, S100 protein, desmin, smooth muscle actin, human melanoma antigen (HMB-45), and α1-antichymotrypsin. Follow-up data showed 4 of 5 patients to have multiple local recurrences, and 1 of these 4 had submandibular lymph node metastasis and a fatal outcome due to uncontrollable tumor growth. Conclusion.—These results suggest that odontogenic clear cell neoplasms are at least low-grade malignancies and should be classified as carcinomas.

scholarly journals Clear Cell Odontogenic Carcinoma: A Rare Case Report

2021 ◽  
Vol 14 (4) ◽  
pp. 1398-1401
Author(s):  
Ashwag Y Aloyouny
Keyword(s):  
Differential Diagnosis ◽  
Case Report ◽  
Clear Cell ◽  
English Literature ◽  
Signs And Symptoms ◽  
Odontogenic Tumor ◽  
Radiographic Findings ◽  
Clear Cell Odontogenic Carcinoma ◽  
Odontogenic Carcinoma ◽  
Slow Growing

Clear Cell Odontogenic Carcinoma (CCOC) is a slow-growing, locally invasive odontogenic tumor affecting the jaws. It usually has confusing clinical characteristics, radiographical and histological features, making its recognition more challenging. In (2005), the WHO has reclassified CCOC as a malignant odontogenic tumor due to its aggressive behavior. This case report is about a woman who aged 42 years old, experienced swelling of the lower jaw and complained of paresthesia of the lips for two years. Radiographic findings showed an extensive, large, multilocular radiolucency lesion associated with scalloping, non-sclerotic border, and crossing the midline of the mandible. Histopathologically, the high-power view illustrated lobules of clear epithelial cells with clear cytoplasm. A review of English literature in PubMed Medline revealed few similar cases of CCOC affecting the mandible. The definitive diagnosis was consistent with CCOC; therefore, the patient was admitted to the hospital and surgical resection of the mandibular tumor was performed under general anesthesia. Long-term follow-up visits showed no signs of recurrence or post-surgical complications. We explain the signs and symptoms of CCOC such as symptomatic or asymptomatic jaw swelling, teeth loosening, displacement and mobility of teeth, and thinning of the mandible. Also, differential diagnosis and the nature of CCOC under the microscope were discussed and explained. The presentation of clear cell tumors is challenging, and it needs a meticulous investigation to determine the type of the tumor for proper diagnosis and management. CCOC should be included in the differential diagnosis list of jaw swelling that associated with slow-growing mass and paresthesia in the affected jaw.

scholarly journals Clear Cell Odontogenic Carcinoma of the Maxilla

2011 ◽  
Vol 54 (3) ◽  
pp. 122-124 ◽  
Author(s):  
Zahide Mine Yazici ◽  
Ozgur Mete ◽  
Zubeyde Elmalı ◽  
İbrahim Sayin ◽  
Rasim Yilmazer ◽  
...  
Keyword(s):  
Clear Cell ◽  
Case Reports ◽  
English Literature ◽  
Odontogenic Tumor ◽  
Clinical Behavior ◽  
Clear Cell Odontogenic Carcinoma ◽  
Odontogenic Carcinoma ◽  
Aggressive Clinical Behavior

Clear cell odontogenic carcinoma (CCOC) is a rare odontogenic tumor associated with aggressive clinical behavior, metastasis and low survival. We report a case of CCOC affecting the maxilla of 62 year-old woman. It was first described as a clinicopathological entity in 1985 and to date only 67 cases were described in the English literature. We are understanding of the behavior of this carcinomas was depend on limited case reports. For these reason we found important to report this case of CCOC in the maxilla.

scholarly journals Clear Cell Odontogenic Carcinoma of the Mandible: A Case Report

Proceedings ◽  
2019 ◽  
Vol 35 (1) ◽  
pp. 67
Author(s):  
Nisi ◽  
Izzetti ◽  
Gabriele
Keyword(s):  
Case Report ◽  
Clear Cell ◽  
Odontogenic Tumor ◽  
Clear Cells ◽  
Clear Cell Odontogenic Carcinoma ◽  
Odontogenic Carcinoma

Clear cell odontogenic carcinoma (CCOC) is a rare malignant odontogenic tumor histologicallycharacterized by sheets and lobules of vacuolated and clear cells. [...]

Clear cell odontogenic carcinoma: report of three cases with pulmonary and lymph node metastases

1989 ◽  
Vol 18 (2) ◽  
pp. 113-118 ◽  
Author(s):  
G. Bang ◽  
H.S. Koppang ◽  
L.S. Hansen ◽  
O. Gilhuus-Moe ◽  
E. Aksdal ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastases ◽  
Clear Cell ◽  
Clear Cell Odontogenic Carcinoma ◽  
Odontogenic Carcinoma ◽  
Node Metastases

scholarly journals Oral Cavity Clear Cell Odontogenic Carcinoma

2015 ◽  
Vol 10 (2) ◽  
pp. 217-220 ◽  
Author(s):  
Daniel Thomas Ginat ◽  
Victoria Villaflor ◽  
Nicole A. Cipriani
Keyword(s):  
Oral Cavity ◽  
Clear Cell ◽  
Clear Cell Odontogenic Carcinoma ◽  
Odontogenic Carcinoma

Genetic Profile of Clear Cell Odontogenic Carcinoma

2003 ◽  
Vol 14 (3) ◽  
pp. 356-362 ◽  
Author(s):  
Francesco Carinci ◽  
Stefano Volinia ◽  
Corrado Rubini ◽  
Massimiliano Fioroni ◽  
Francesca Francioso ◽  
...  
Keyword(s):  
Clear Cell ◽  
Genetic Profile ◽  
Clear Cell Odontogenic Carcinoma ◽  
Odontogenic Carcinoma
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