Malignant Transformation of a Keratocystic Odontogenic Tumor: A Rare Occurrence

2014 ◽  
Vol 117 (5) ◽  
pp. e411
Keyword(s):  
Malignant Transformation ◽  
Odontogenic Tumor ◽  
Keratocystic Odontogenic Tumor ◽  
Rare Occurrence

Malignant transformation of keratocystic odontogenic tumor: Two case reports

2013 ◽  
Vol 34 (4) ◽  
pp. 357-361 ◽  
Author(s):  
Bernard Tan ◽  
Tay Sok Yan ◽  
Lee Shermin ◽  
Kwa Chong Teck ◽  
Poon Choy Yoke ◽  
...  
Keyword(s):  
Malignant Transformation ◽  
Case Reports ◽  
Odontogenic Tumor ◽  
Keratocystic Odontogenic Tumor

A recurrence case of keratocystic odontogenic tumor

2017 ◽  
Vol 4 (1) ◽  
pp. 1-4
Author(s):  
Tejavathi Nagaraj ◽  
Haritma Nigam ◽  
Arundhati Biswas ◽  
C. K. Sumana
Keyword(s):  
Odontogenic Tumor ◽  
Keratocystic Odontogenic Tumor

Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population

2007 ◽  
Vol 49 (3) ◽  
pp. 229-235 ◽  
Author(s):  
Ataollah Habibi ◽  
Nasrollah Saghravanian ◽  
Mehdi Habibi ◽  
Ehsan Mellati ◽  
Morteza Habibi
Keyword(s):  
Retrospective Study ◽  
Iranian Population ◽  
Odontogenic Tumor ◽  
Keratocystic Odontogenic Tumor

Simultaneous Palatal Pleomorphic Adenoma and Mandibular Keratocystic Odontogenic Tumor in a Pediatric Patient

2011 ◽  
Vol 22 (6) ◽  
pp. 2347-2350 ◽  
Author(s):  
Francesco Arcuri ◽  
Fabrizio Grivetto ◽  
Giuseppe Poglio ◽  
Matteo Brucoli ◽  
Arnaldo Benech
Keyword(s):  
Pleomorphic Adenoma ◽  
Pediatric Patient ◽  
Odontogenic Tumor ◽  
Keratocystic Odontogenic Tumor

Evaluation of the Connective Tissue Wall in Sporadic Cases of Keratocystic Odontogenic Tumor (KCOT) Using MMP-9 and Confocal Microscopy: A Retrospective Study

2021 ◽  
Vol 12 (1) ◽  
pp. 134-143
Author(s):  
Merlin Jayaraj ◽  
Pratibha Ramani ◽  
Herald J. Sherlin
Keyword(s):  
Confocal Microscopy ◽  
Connective Tissue ◽  
Dentigerous Cyst ◽  
Odontogenic Tumor ◽  
Biological Behavior ◽  
Keratocystic Odontogenic Tumor ◽  
Extracellular Matrix Components ◽  
Sporadic Cases ◽  
Odontogenic Lesion ◽  
Inherent Nature

Background: Keratocystic odontogenic tumor (KCOT) is an odontogenic lesion which manifests distinct biological behavior. Predominant studies in KCOT attribute this behavior to high epithelial proliferative capacity. Besides, a few studies facet loosely arranged collagen can contribute to the behavior of KCOT. Matrix metalloproteinases (MMP) are enzymes that degrade extracellular matrix components under both physiologic and pathologic conditions. The loosely arranged collagen in connective tissue wall of KCOT could be related to the degree of MMP-9 expression. Aim: To evaluate the arrangement of collagen fibers along with immunoexpression of MMP-9 and to relate to its neoplastic biologic behavior in sporadic cases of KCOT. Materials and Methods: KCOT ( n = 23) and dentigerous cyst (DC) ( n = 15) samples were processed for the following techniques: Masson’s trichrome stain for light microscopy, PMA-PSR stain for confocal microscopy, and MMP-9 for immunohistochemistry. Results: In Masson’s trichrome analysis, correlation of collagen fiber arrangement in the deeper regions with color intensity for KCOT was found to be statistically significant ( P = .033). In confocal microscopy, there was no difference between intensities in KCOT ( P = .990) and DC ( P = .233), respectively. The immunoexpression of MMP-9 in the connective tissue wall of DC (73.3%) was relatively higher than that of KCOT (60.8%). However, on comparison between KCOT and DC in the presence of inflammation, the immunoexpression of MMP-9 was higher in DC (100%) than KCOT (69.9%) and was statistically significant ( P = .028). Conclusion: It was concluded that the loose connective tissue wall in KCOT is because of the inherent nature of the lesion that could facilitate its biologic behavior. If inflammation is present, this could further aggravate the tumorigenic behavior.

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