Beta-2 adrenergic receptor expression in surgical margins of oral squamous cell carcinoma

2012 ◽  
Vol 114 (4) ◽  
pp. e83
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Adrenergic Receptor ◽  
Receptor Expression ◽  
Surgical Margins ◽  
Beta 2

Prognostic significance of beta-2 adrenergic receptor in oral squamous cell carcinoma

2012 ◽  
Vol 10 (1) ◽  
pp. 51-59 ◽  
Author(s):  
Diego Mauricio Bravo-Calderón ◽  
Denise Tostes Oliveira ◽  
Aparecido Nilceu Marana ◽  
Suely Nonogaki ◽  
André Lopes Carvalho ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Adrenergic Receptor ◽  
Prognostic Significance ◽  
Beta 2

scholarly journals DNA Methylation Markers from Negative Surgical Margins Can Predict Recurrence of Oral Squamous Cell Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2915
Author(s):  
Bruna Pereira Sorroche ◽  
Fazlur Rahman Talukdar ◽  
Sheila Coelho Soares Lima ◽  
Matias Eliseo Melendez ◽  
Ana Carolina de Carvalho ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumor Recurrence ◽  
Surgical Margins ◽  
Risk Scores ◽  
Marker Panel ◽  
Specificity And Sensitivity

The identification of molecular markers in negative surgical margins of oral squamous cell carcinoma (OSCC) might help in identifying residual molecular aberrations, and potentially improve the prediction of prognosis. We performed an Infinium MethylationEPIC BeadChip array on 32 negative surgical margins stratified based on the status of tumor recurrence in order to identify recurrence-specific aberrant DNA methylation (DNAme) markers. We identified 2512 recurrence-associated Differentially Methylated Positions (DMPs) and 392 Differentially Methylated Regions (DMRs) which were enriched in cell signaling and cancer-related pathways. A set of 14-CpG markers was able to discriminate recurrent and non-recurrent cases with high specificity and sensitivity rates (AUC 0.98, p = 3 × 10−6; CI: 0.95–1). A risk score based on the 14-CpG marker panel was applied, with cases classified within higher risk scores exhibiting poorer survival. The results were replicated using tumor-adjacent normal HNSCC samples from The Cancer Genome Atlas (TCGA). We identified residual DNAme aberrations in the negative surgical margins of OSCC patients, which could be informative for patient management by improving therapeutic intervention. This study proposes a novel DNAme-based 14-CpG marker panel as a promising predictor for tumor recurrence, which might contribute to improved decision-making for the personalized treatment of OSCC cases.

scholarly journals Chemokine Receptor Expression in Oral Squamous Cell Carcinoma

2007 ◽  
Vol 4 (2) ◽  
pp. 73-85 ◽  
Author(s):  
Katsumi Muraoka ◽  
Kazuhiko Okumura ◽  
Hiroyuki Kitajo ◽  
Hidetaka Kato ◽  
Makoto Arisue
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Chemokine Receptor ◽  
Receptor Expression ◽  
Chemokine Receptor Expression

Impact of dysplastic surgical margins for patients with oral squamous cell carcinoma

Oral Oncology ◽  
2019 ◽  
Vol 97 ◽  
pp. 1-6 ◽  
Author(s):  
Tseng-Cheng Chen ◽  
Huei-Lun Chang ◽  
Tsung-Lin Yang ◽  
Pei-Jen Lou ◽  
Yih-Leong Chang ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Surgical Margins
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