Matrix metalloproteinases, tissue inhibitors of metalloproteinases, and growth factors regulate the aggressiveness and proliferative activity of keratocystic odontogenic tumors

2012 ◽  
Vol 114 (4) ◽  
pp. 487-496 ◽  
Author(s):  
André Luis Ribeiro Ribeiro ◽  
Rafaela M. Nobre ◽  
Sérgio M. Alves-Junior ◽  
Maria S.S. Kataoka ◽  
Regina F.F. Barroso ◽  
...  
Keyword(s):  
Growth Factors ◽  
Matrix Metalloproteinases ◽  
Proliferative Activity ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Odontogenic Tumors ◽  
Tissue Inhibitors ◽  
Keratocystic Odontogenic Tumors

Expression of matrix metalloproteinases (MMPs-2, -7, -9, and -26) and tissue inhibitors of metalloproteinases (TIMPs-1 and -2) in pleomorphic adenomas and adenoid cystic carcinomas

2018 ◽  
Vol 275 (12) ◽  
pp. 3075-3082 ◽  
Author(s):  
Valéria Souza Freitas ◽  
Jean Nunes dos Santos ◽  
Pedro Paulo de Andrade Santos ◽  
Cassiano Francisco Weege Nonaka ◽  
Leão Pereira Pinto ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Tissue Inhibitors ◽  
Adenoid Cystic ◽  
Pleomorphic Adenomas

scholarly journals Expression of Matrix Metalloproteinases, Tissue Inhibitors of Metalloproteinases, and Interleukins in Vertebral Cartilage Endplate

2018 ◽  
Vol 10 (4) ◽  
pp. 306-311 ◽  
Author(s):  
Jian-feng Zhang ◽  
Gang-liang Wang ◽  
Zhi-jie Zhou ◽  
Xiang-qian Fang ◽  
Shuai Chen ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Tissue Inhibitors ◽  
Cartilage Endplate

Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human chondrosarcomasNote

Apmis ◽  
2001 ◽  
Vol 109 (4) ◽  
pp. 305-315 ◽  
Author(s):  
M. Soderstrom ◽  
H. T. Aro ◽  
M. Ahonen ◽  
N. Johansson ◽  
A. Aho ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Tissue Inhibitors

scholarly journals Imbalance between matrix metalloproteinases and their tissue inhibitors in preeclampsia and gestational trophoblastic diseases

Reproduction ◽  
2016 ◽  
Vol 152 (1) ◽  
pp. 11-22 ◽  
Author(s):  
Beenish Rahat ◽  
Renuka Sharma ◽  
Rashmi Bagga ◽  
Abid Hamid ◽  
Jyotdeep Kaur
Keyword(s):  
Matrix Metalloproteinases ◽  
Differential Expression ◽  
Normal Pregnancy ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Tissue Inhibitors ◽  
Trophoblastic Diseases ◽  
Histone Trimethylation ◽  
Gestational Trophoblastic Diseases ◽  
Normal Gestation ◽  
Cancerous Cells

The invasion cascade exhibited by placental trophoblasts and cancerous cells bears many similarities, and it is attributed to extracellular matrix degradation mediated by matrix metalloproteinases (MMPs). Although proper and controlled invasion by trophoblasts into the maternal uterus is an essential requirement for maintenance of normal pregnancy, any abnormality in this phenomenon results in the development of invasion-related disorders such as gestational trophoblastic diseases (GTDs) and preeclampsia. We studied the epigenetic basis of differential expression of two placental MMPs (MMP2andMMP9) and tissue inhibitors of metalloproteinases (TIMP2andTIMP1) during normal gestation and invasion-related disorders, i.e., preeclampsia and GTDs. Our study suggests the association of H3K9/27me3 with differential expression of these MMPs and their inhibitors, which regulate the placental invasion during normal pregnancy, whereas no role of CpG methylation was observed in the differential expression of MMPs/TIMPs. Further, development of GTDs was associated with abnormally higher expression of these MMPs and lower levels of their inhibitors, whereas the reverse trends were observed for MMPs and their TIMPs in case of preeclampsia, in association with abnormal changes in H3K9/27me3. These results suggest the involvement of higher levels of MMPs in an aggressive invasive behavior depicted by GTDs, whereas lower levels of these MMPs in shallow and poor invasive phenotype associated with preeclampsia. Thus, our study shows the significance of a proper balance regulated by histone trimethylation between differential expression of MMPs and their TIMPs for maintaining normal pregnancy and its deregulation as a contributing factor for pathogenesis of invasive disorders during pregnancy.

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