Soy protein supports cardiovascular health by downregulating hydroxymethylglutaryl–coenzyme A reductase and sterol regulatory element-binding protein–2 and increasing antioxidant enzyme activity in rats with dextran sodium sulfate–induced mild systemic inflammation

2011 ◽  
Vol 31 (12) ◽  
pp. 922-928 ◽  
Author(s):  
Tanya G. Marsh ◽  
Rachel K. Straub ◽  
Fatima Villalobos ◽  
Mee Young Hong
Keyword(s):  
Enzyme Activity ◽  
Antioxidant Enzyme ◽  
Systemic Inflammation ◽  
Soy Protein ◽  
Sodium Sulfate ◽  
Cardiovascular Health ◽  
Regulatory Element ◽  
Antioxidant Enzyme Activity ◽  
Element Binding Protein ◽  
Sterol Regulatory Element

Antioxidant Enzyme Levels Inversely Covary with Hearing Loss After Amikacin Treatment

2003 ◽  
Vol 14 (03) ◽  
pp. 134-143 ◽  
Author(s):  
James J. Klemens ◽  
Robert P. Meech ◽  
Larry F. Hughes ◽  
Satu Somani ◽  
Kathleen C.M. Campbell
Keyword(s):  
Hearing Loss ◽  
Enzyme Activity ◽  
Antioxidant Enzyme ◽  
Guinea Pigs ◽  
Auditory Brainstem ◽  
Antioxidant Enzyme Activity ◽  
Control Group ◽  
Glutathione S Transferase ◽  
Brainstem Response ◽  
The Difference

This study's purpose was to determine if a correlation exists between cochlear antioxidant activity changes and auditory function after induction of aminoglycoside (AG) ototoxicity. Two groups of five 250-350 g albino guinea pigs served as subjects. For 28 days, albino guinea pigs were administered either 200 mg/kg/day amikacin, or saline subcutaneously. Auditory brainstem response testing was performed prior to the first injection and again before sacrifice, 28 days later. Cochleae were harvested and superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase activities and malondialdehyde levels were measured. All antioxidant enzymes had significantly lower activity in the amikacin group (p ≤ 0.05) than in the control group. The difference in cochlear antioxidant enzyme activity between groups inversely correlated significantly with the change in ABR thresholds. The greatest correlation was for the high frequencies, which are most affected by aminoglycosides. This study demonstrates that antioxidant enzyme activity and amikacin-induced hearing loss significantly covary.

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