Purple sweet potato anthocyanins attenuate hepatic lipid accumulation through activating adenosine monophosphate–activated protein kinase in human HepG2 cells and obese mice

2011 ◽  
Vol 31 (12) ◽  
pp. 896-906 ◽  
Author(s):  
Yong Pil Hwang ◽  
Jae Ho Choi ◽  
Eun Hee Han ◽  
Hyung Gyun Kim ◽  
Ji-Hyang Wee ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Sweet Potato ◽  
Lipid Accumulation ◽  
Hepg2 Cells ◽  
Adenosine Monophosphate ◽  
Obese Mice ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation ◽  
Purple Sweet Potato

Scopoletin prevents alcohol-induced hepatic lipid accumulation by modulating the AMPK–SREBP pathway in diet-induced obese mice

Metabolism ◽  
2014 ◽  
Vol 63 (4) ◽  
pp. 593-601 ◽  
Author(s):  
Hae-In Lee ◽  
Kyeong Won Yun ◽  
Kown-Il Seo ◽  
Myung-Joo Kim ◽  
Mi-Kyung Lee
Keyword(s):  
Lipid Accumulation ◽  
Obese Mice ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation

Houttuynia cordata Attenuates Lipid Accumulation via Activation of AMP-Activated Protein Kinase Signaling Pathway in HepG2 Cells

2014 ◽  
Vol 42 (03) ◽  
pp. 651-664 ◽  
Author(s):  
Hyun Kang ◽  
Sushruta Koppula
Keyword(s):  
Protein Kinase ◽  
High Glucose ◽  
Lipid Accumulation ◽  
Hepg2 Cells ◽  
Fatty Acid Synthase ◽  
Molecular Mechanisms ◽  
Regulatory Element ◽  
Adenosine Monophosphate ◽  
Perennial Herb ◽  
Houttuynia Cordata

Houttuynia cordata (H. cordata) from the family Saururaceae is a perennial herb native to Southeast Asia. It possesses a range of medicinal properties to treat several disease symptoms including allergic inflammation and anaphylaxis. In the present investigation, we provided the molecular mechanisms underlying the role of H. cordata extract (HCE) in the prevention of high glucose-induced lipid accumulation in human HepG2 hepatocytes. HepG2 cells were pre-treated with various concentrations of HCE (0, 10, 20, 40, and 80 μg/mL) and treated with serum-free medium with normal glucose (5 mM) for 1 h, followed by exposure to high glucose (25 mM D-glucose) for 24 h. HCE significantly and dose-dependently attenuated lipid accumulation in human HepG2 hepatocytes when exposed to high glucose (25 mM D-glucose) (p < 0.05, p < 0.01 and p < 0.001 at 20, 40, and 80 μg/mL concentrations, respectively). Further, HCE attenuated the expression of fatty acid synthase (FAS), sterol regulatory element-binding protein-1 and glycerol 3-phosphate acyltransferases (GPATs). The adenosine monophosphate-activated protein kinase (AMPK) was also activated by HCE treatment when exposed to high glucose (25 mM D-glucose) in human HepG2 hepatocytes. This study suggests the hypolipidemic effects of HCE by the inhibition of lipid biosynthesis mediated through AMPK signaling, which may play an active role and can be developed as an anti-obesity agent.

scholarly journals Short-term treatment with metformin reduces hepatic lipid accumulation but induces liver inflammation in obese mice

2018 ◽  
Vol 26 (4) ◽  
pp. 1103-1115 ◽  
Author(s):  
Alexandre Abilio de Souza Teixeira ◽  
Camila O. Souza ◽  
Luana A. Biondo ◽  
Loreana Sanches Silveira ◽  
Edson A. Lima ◽  
...  
Keyword(s):  
Lipid Accumulation ◽  
Term Treatment ◽  
Liver Inflammation ◽  
Obese Mice ◽  
Short Term ◽  
Short Term Treatment ◽  
Hepatic Lipid ◽  
Hepatic Lipid Accumulation
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