Vanadyl sulfate treatment improves oxidative stress and increases serum paraoxonase activity in streptozotocin-induced diabetic rats

2006 ◽  
Vol 26 (12) ◽  
pp. 670-676 ◽  
Author(s):  
Sibel Tas ◽  
Emre Sarandol ◽  
Sedef Ziyanok-Ayvalik ◽  
Nihal Ocak ◽  
Zehra Serdar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Rats ◽  
Vanadyl Sulfate ◽  
Paraoxonase Activity ◽  
Serum Paraoxonase

scholarly journals Vitamin B6 Supplementation Improves Oxidative Stress and Enhances Serum Paraoxonase/Arylesterase Activities in Streptozotocin-Induced Diabetic Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Sibel Taş ◽  
Emre Sarandöl ◽  
Melahat Dirican
Keyword(s):  
Oxidative Stress ◽  
Vitamin B6 ◽  
Antioxidant Status ◽  
Total Cholesterol Level ◽  
Diabetic Rats ◽  
Serum Total Cholesterol Level ◽  
Metabolic Disturbances ◽  
Erythrocyte Superoxide Dismutase ◽  
Serum Paraoxonase ◽  
Group D

The purpose of this study was to investigate the effects of vitamin B6 (Vit B6) on oxidant and antioxidant status in streptozotocin-induced diabetic rats. Thirty-two Wistar rats were divided into four groups: control (C), control + Vit B6 group (C + Vit B6), diabetes (D), and diabetes + Vit B6 group (D + Vit B6). Vit B6 (4 mg/kg body weight) was administered in drinking water for 4 weeks after the induction of diabetes. Vitamin B6 reduced serum total cholesterol level in the C + Vit B6 (P< 0.01) and D + Vit B6 (P< 0.05) groups. Plasma and tissue malondialdehyde levels were reduced in the C + Vit B6 and D + Vit B6 groups. Whole blood glutathione peroxidase (GSH-Px) and erythrocyte superoxide dismutase (SOD) activities were higher in the D group (P< 0.05). GSH-Px and SOD activities were increased in C + Vit B6 group while these parameters decreased in the D + Vit B6 group. Paraoxonase and arylesterase activities were decreased in the D group while they were increased in C + Vit B6 and D + Vit B6 groups. The results of present study suggest that vitamin B6 supplementation might be a promising adjunctive agent for improving oxidative stress and metabolic disturbances and for preventing diabetic complications including atherogenesis.

Serum paraoxonase activity and oxidative stress levels in patients with cutaneous anthrax

2016 ◽  
Vol 36 (7) ◽  
pp. 663-669
Author(s):  
S Karadas ◽  
M Aslan ◽  
MR Ceylan ◽  
M Sunnetcioglu ◽  
N Bozan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Paraoxonase 1 ◽  
Pon1 Activity ◽  
Bacterial Disease ◽  
Healthy Controls ◽  
Paraoxonase Activity ◽  
Cutaneous Anthrax ◽  
Bacterium Bacillus ◽  
Serum Paraoxonase ◽  
And Oxidative Stress

Introduction: Anthrax is a bacterial disease caused by the aerobic sporeforming bacterium Bacillus anthracis. It has been suggested that oxidative stress plays an important role in the pathogenesis of B. anthracis. The aim of this study was to investigate serum paraoxonase 1 (PON1) activity, catalase activity, malondialdehyde (MDA) levels, and superoxide dismutase (SOD) levels in patients with cutaneous anthrax. Materials and methods: Fifteen patients with cutaneous anthrax and 15 healthy controls were enrolled in this study. The serum MDA levels, SOD levels, paraoxonase, arylesterase, and catalase activities were measured using a spectrophotometer. Results: The serum SOD levels, paraoxonase, arylesterase, and catalase activities were significantly lower in patients with cutaneous anthrax than in controls (for all, p < 0.001), whereas MDA levels were significantly higher ( p < 0.001). No significant correlation was found between serum paraoxonase activity, arylesterase activity, SOD levels, and MDA levels (all, p > 0.05) in patients with cutaneous anthrax. Conclusions: The current study was the first to show decreased antioxidant levels and increased oxidant levels in patients with cutaneous anthrax. Therefore, decreased PON1 activity may play a role in the pathogenesis of cutaneous anthrax.

Serum paraoxonase activity and oxidative stress in patients with adult nephrotic syndrome

2011 ◽  
Vol 218 (1) ◽  
pp. 243-246 ◽  
Author(s):  
Yasemin Usul Soyoral ◽  
Mehmet Aslan ◽  
Habib Emre ◽  
Huseyin Begenik ◽  
Fatih Mehmet Erdur ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nephrotic Syndrome ◽  
Paraoxonase Activity ◽  
Serum Paraoxonase ◽  
And Oxidative Stress

Diabetes-altered gene expression in rat skeletal muscle corrected by oral administration of vanadyl sulfate

2006 ◽  
Vol 26 (3) ◽  
pp. 192-201 ◽  
Author(s):  
Gail R. Willsky ◽  
Lai-Har Chi ◽  
Yulan Liang ◽  
Daniel P. Gaile ◽  
Zihua Hu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Oral Administration ◽  
Clinical Symptoms ◽  
Diabetic Rats ◽  
Vanadyl Sulfate ◽  
Diabetic Patients ◽  
Strong Negative Correlation ◽  
Stress Genes ◽  
Altered Gene

Treatment with vanadium, a representative of a class of antidiabetic compounds, alleviates diabetic hyperglycemia and hyperlipidemia. Oral administration of vanadium compounds in animal models and humans does not cause clinical symptoms of hypoglycemia, a common problem for diabetic patients with insulin treatment. Gene expression, using Affymetrix arrays, was examined in muscle from streptozotocin-induced diabetic and normal rats in the presence or absence of oral vanadyl sulfate treatment. This treatment affected normal rats differently from diabetic rats, as demonstrated by two-way ANOVA of the full array data. Diabetes altered the expression of 133 genes, and the expression of 30% of these genes dysregulated in diabetes was normalized by vanadyl sulfate treatment. For those genes, the ratio of expression in normal animals to the expression in diabetic animals showed a strong negative correlation with the ratio of expression in diabetic animals to the expression in diabetic animals treated with vanadyl sulfate ( P = −0.85). The genes identified belong to six major metabolic functional groups: lipid metabolism, oxidative stress, muscle structure, protein breakdown and biosynthesis, the complement system, and signal transduction. The identification of oxidative stress genes, coupled with the known oxidative chemistry of vanadium, implicates reactive oxygen species in the action of this class of compounds. These results imply that early transition metals or compounds formed from their chemical interactions with other metabolites may act as general transcription modulators, a role not usually associated with this class of compounds.

Association between serum paraoxonase activity and oxidative stress in acute coronary syndromes

2004 ◽  
Vol 59 (6) ◽  
pp. 606-611 ◽  
Author(s):  
Ceyda KABAROGLU ◽  
Isil MUTAF ◽  
Bahar BOYDAK ◽  
Dilek ÖZMEN ◽  
Sara HABIF ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Coronary Syndromes ◽  
Paraoxonase Activity ◽  
Coronary Syndromes ◽  
Serum Paraoxonase ◽  
And Oxidative Stress
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