AIM: The objective of the current study was to assess the influence of oral multivitamins supplementation on some oxidative stress parameters (serum Vitamin A, C, E, Zinc, Malondialdehyde (MDA)) and lipid profile among Sudanese patients with type- 2 diabetes mellitus (T2DM).
MATERIAL AND METHOD: Three hundred Sudanese patients with T2DM and Hundred healthy subjects (control group) were enrolled in this cross-sectional study. Blood was collected after overnight fasting for 10-12 hrs. Fasting plasma glucose (FBG), lipid profiles, Glycosylated haemoglobin (HbA1c%), Serum zinc, Malondialdehyde (MDA), Vitamins A, E, and C levels were measured using standardised laboratory techniques. Data was collected with the help of a structured questionnaire and direct interview.
RESULTS: Biochemical parameters of the study population were shown a highly significant difference (P value < 0.05), between the means of serum vitamin A, C, E, Zinc, MDA, HbA1c, triglycerides, HDL, FBG, total cholesterol and LDL. Significant differences in serum vitamin A, C, E, Zinc, MDA, triglycerides, HDL and FBG between people with diabetes who used multivitamins and diabetics who did not use it (P-value < 0.05).
CONCLUSION: The study observed a significant increase in serum levels of vitamin A, C & E and other biomarkers parameters in patients with T2DM who take oral multivitamins supplements; such improvement may lead to minimising the diabetic complications. Further studies are needed to explore the possible therapeutic role of multivitamins supplements for T2DM patients.
Barnidipine compared to lercanidipine in addition to losartan on endothelial damage and oxidative stress parameters in patients with hypertension and type 2 diabetes mellitus