Parenteral amino acid supplementation with high-dose insulin prevents hypoaminoacidemia during cardiac surgery

Nutrition ◽  
2020 ◽  
Vol 69 ◽  
pp. 110566
Author(s):  
Mengyin Hong ◽  
Linda Wykes ◽  
Dominique Shum-Tim ◽  
Evan Nitschmann ◽  
Helen Bui ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Amino Acid ◽  
High Dose ◽  
Amino Acid Supplementation ◽  
Acid Supplementation

scholarly journals Recurrent Herpes Zoster Ophthalmicus Preceded by Anabolic Steroids and High-Dose L-Arginine

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Stephen A. LoBue ◽  
Adam Goldman ◽  
Richard A. Giovane ◽  
Stacy M. Carlson ◽  
Michael Bivona ◽  
...  
Keyword(s):  
Herpes Zoster ◽  
Amino Acid ◽  
Anabolic Steroids ◽  
High Dose ◽  
Cell Mediated Immunity ◽  
Amino Acid Supplementation ◽  
Herpes Zoster Ophthalmicus ◽  
Acid Supplementation ◽  
Recurrent Herpes ◽  
Arginine Supplementation

Purpose. To report a case of a 34-year-old male with recurrent herpes zoster ophthalmicus (HZO) preceded by a 6-week cycle of anabolic steroids and high-dose amino acid supplementation. Case Presentation. A 34-year-old man presented to our institution for left eye pain for one week associated with a vesicular rash in the V1 dermatome, respecting the midline. The patient had no significant past medical or past ocular history, including systemic immunosuppressive agents or HIV. However, prior to the onset of his symptoms the patient had completed a 6-week course of anabolic steroids including trenbolone, deca-durabolin, and testosterone as well as high-dose arginine supplementation averaging more than 40 grams a day. The best-corrected vision was 20/25 OS with slit-lamp examination remarkable for punctate staining and pseudodendrites at 6 o’clock, outside the visual axis. The patient was treated with oral acyclovir 800 mg five times a day for seven days along with prednisolone QID and moxifloxacin QID which was tapered over a month. Four months after resolution, the patient developed a recurrent HZO keratitis preceded by another cycle of anabolic steroids and amino acid supplementation. Conclusion. In vitro L-arginine supplementation has been associated with the proliferation and virulence of a variety of herpes viruses. Anabolic steroids have also been demonstrated by various studies to negatively affect cell-mediated immunity necessary to prevent viral infection. Thus, it is possible that anabolic steroids in conjunction with increased L-arginine intake may have precipitated a recurrent HZO in a previously healthy, immunocompetent individual.

Meat and Bone Characteristics of Broiler Chickens Fed Groundnut Cake-Based Diets as Affected by Graded Dietary Supplements of Crystalline L- Lysine and DL- Methionine

2016 ◽  
Vol 6 (1) ◽  
pp. 846-852
Author(s):  
Olugbenga Adeniran Ogunwole ◽  
B. C Majekodunmi ◽  
R. A Faboyede ◽  
D. Ogunsiji
Keyword(s):  
Amino Acid ◽  
Broiler Chickens ◽  
Bone Development ◽  
Thiobarbituric Acid ◽  
Broiler Chicks ◽  
Amino Acid Supplementation ◽  
Acid Supplementation ◽  
Groundnut Cake ◽  
Randomized Design ◽  
Phosphorus And Potassium

Effects of supplemental dietary lysine and methionine in a Groundnut Cake (GNC) based diets on meat and bone characteristics of broiler chickens were investigated. In a completely randomized design, a total of 168 one - day – old Arbor acre broiler chicks were randomly allocated to seven dietary treatments each in triplicate of eight birds per replicate. The Seven starter and finishers’ diets were: GNC based diets without any amino acid (lysine or methionine) supplementation (T1); GNC diet + 0.2% lysine (T2); GNC diet + 0.4% lysine (T3); GNC diet + 0.2% methionine (T4); GNC diet + 0.4% methionine (T5); GNC diet + 0.2 lysine and 0.2% methionine (T6) and GNC diet + 0.4% lysine and 0.4% methionine (T7). Experimental diets and water were offered to birds ad libitum in an experiment lasting six-week. At day 42, two birds per replicate were slaughtered, meat and bone characteristics determined. There were significant variations (P<0.05) in the crude protein (%) and ether extract (%), pH1 and pH2 of meat. Thiobarbituric acid reactive substances composition of meat at days 0, 5, and 10 were similar (P<0.05) and were not affected by dietary amino acid supplementation. Tibiotarsal index (mg/mm) of bone (22.10, 27.25, 33.35, 31.40, 28.70, 31.45 and 29.75 for broilers on T1, T2, T3, T4, T5, T6 and T7, respectively) were increased significantly (P<0.05) by amino acid supplementation. Significantly differences (P<0.05) were observed in the calcium, phosphorus and potassium (%) contents of broilers’ bone across treatments. Supplemental lysine and both lysine and methionine improved meat quality and bone development of broiler chickens in this study.

A rational design approach for amino acid supplementation in hepatocyte culture

2009 ◽  
Vol 103 (6) ◽  
pp. 1176-1191 ◽  
Author(s):  
Hong Yang ◽  
Charles M. Roth ◽  
Marianthi G. Ierapetritou
Keyword(s):  
Amino Acid ◽  
Rational Design ◽  
Design Approach ◽  
Hepatocyte Culture ◽  
Amino Acid Supplementation ◽  
Acid Supplementation

scholarly journals Isolation of a post-PKS C–C branching jadomycin from S. venezuelae ISP5230 in the presence of 8-aminooctanoic acid

2018 ◽  
Vol 96 (7) ◽  
pp. 760-764 ◽  
Author(s):  
Jeanna M. MacLeod ◽  
Stephanie M. Forget ◽  
Camilo F. Martinez-Farina ◽  
David L. Jakeman
Keyword(s):  
Natural Products ◽  
Amino Acid ◽  
Natural Product ◽  
Intramolecular Cyclization ◽  
Nucleophilic Addition ◽  
Culture Method ◽  
Amino Acid Supplementation ◽  
Acid Supplementation

The jadomycin family of natural products was first identified and characterized by Vining and co-workers at Dalhousie University in the 1990s. Herein, we report findings from a recently developed co-amino acid supplementation culture method with S. venezuelae ISP5230 using 8-aminooctanoic acid, where the major natural product was a jadomycin variant omitting an E-ring (1). These results reinforce that the 3a position is susceptible to nucleophilic addition by cellular metabolites in jadomycin biosynthesis when intramolecular cyclization is unfavorable. Further, the cytotoxicity data for several unsubstituted E-ring jadomycins are reported and discussed.

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