scholarly journals Efficacy of vitamin D supplementation according to vitamin D-binding protein polymorphisms

Nutrition ◽  
2019 ◽  
Vol 63-64 ◽  
pp. 148-154 ◽  
Author(s):  
Nasser M. Al-Daghri ◽  
Abdul Khader Mohammed ◽  
Ihtisham Bukhari ◽  
Maryam Rikli ◽  
Saba Abdi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Binding Protein ◽  
Vitamin D Supplementation ◽  
Vitamin D Binding Protein ◽  
Protein Polymorphisms

scholarly journals SAT-021 Efficacy of Vitamin D Supplementation According to Vitamin D Binding Protein Polymorphisms

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Nasser Al-Daghri ◽  
Ihtisham Bukhari ◽  
Maryam Rikli ◽  
Saba Abdi ◽  
Mohammed Ansari ◽  
...  
Keyword(s):  
Vitamin D ◽  
Binding Protein ◽  
Vitamin D Supplementation ◽  
Vitamin D Binding Protein ◽  
Protein Polymorphisms

scholarly journals Influence of vitamin D binding protein polymorphism, demographics and lifestyle factors on vitamin D status of healthy Malaysian pregnant women

2020 ◽  
Author(s):  
Siew-Siew Lee ◽  
King-Hwa Ling ◽  
Maiza Tusimin ◽  
Raman Subramaniam ◽  
Kartini Farah Rahim ◽  
...  
Keyword(s):  
Vitamin D ◽  
Gene Polymorphism ◽  
Pregnant Women ◽  
Binding Protein ◽  
Lifestyle Factors ◽  
Vitamin D Supplementation ◽  
Dietary Vitamin ◽  
Vitamin D Binding Protein ◽  
Significant Positive Association ◽  
Cross Sectional

Abstract Background: Vitamin D deficiency (VDD) has been related to vitamin D binding protein (GC) gene polymorphism, demographics and lifestyle factors in different populations. However, previous studies only focused on demographic and lifestyle factors or genetic factors alone. Therefore, this cross-sectional study aimed to assess the association between GC gene polymorphism, demographics and lifestyle factors with VDD among Malaysian pregnant women. Method: Information on demographic characteristics, dietary vitamin D intake from supplement and food, time spent outdoors, skin type and clothing were collected using questionnaire. Plasma total 25-hydroxyvitamin D (25OHD) levels were measured using a Ultra-High-Performance Chromatography (UHPLC). Maternal GC single nucleotide polymorphisms (SNPs) (rs4588 and rs7041) were determined using restriction fragment length polymorphism (RFLP) technique. Results: Results showed that 50.2% of pregnant women were vitamin D deficient (25OHD <30 nmol/L). VDD (25OHD <30 nmol/L) was significantly associated with age, veiled clothing, maternal vitamin D intakes, from both food and supplements, and GC rs7041(and GC diplotypes). In contrast to previous studies that reported for non-pregnant population, significant positive association was found between CC genotype for SNP GC rs7041, GC 1s-1s and GC If-2 with risk of VDD (25OHD <30 nmol/L). Conclusions: The high prevalence of maternal VDD found in this study suggests the need for urgent development and implementation of vitamin D supplementation or fortification strategies to reduce VDD among pregnant women. The discrepancy in the association between GC rs7041 gene polymorphism and VDD reflects the variation in the factors associated with VDD in pregnancy compared to non-pregnant state

The Association Between Vitamin D Binding Protein Polymorphisms and Vitamin D Level on Epilepsy in China

2018 ◽  
Vol 37 (9) ◽  
pp. 786-790 ◽  
Author(s):  
Haidong Wang ◽  
Yujin Guo ◽  
Gongying Li ◽  
Ruining Xie ◽  
Zhimei Zhang ◽  
...  
Keyword(s):  
Vitamin D ◽  
Binding Protein ◽  
Vitamin D Binding Protein ◽  
Protein Polymorphisms

scholarly journals Vitamin D Receptor (VDR) and Group-Specific Component (GC, Vitamin D–Binding Protein) Polymorphisms in Myopia

2011 ◽  
Vol 52 (6) ◽  
pp. 3818 ◽  
Author(s):  
Donald O. Mutti ◽  
Margaret E. Cooper ◽  
Ecaterina Dragan ◽  
Lisa A. Jones-Jordan ◽  
Melissa D. Bailey ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Binding Protein ◽  
Vitamin D Binding Protein ◽  
Specific Component ◽  
Group Specific Component ◽  
Protein Polymorphisms

scholarly journals Effects of vitamin D binding protein phenotypes and vitamin D supplementation on serum total 25(OH)D and directly measured free 25(OH)D

2016 ◽  
Vol 174 (4) ◽  
pp. 445-452 ◽  
Author(s):  
Stina T Sollid ◽  
Moira Y S Hutchinson ◽  
Vivian Berg ◽  
Ole M Fuskevåg ◽  
Yngve Figenschau ◽  
...  
Keyword(s):  
Vitamin D ◽  
Binding Protein ◽  
Controlled Trial ◽  
Inverse Correlation ◽  
Vitamin D Supplementation ◽  
Vitamin D Binding Protein ◽  
Baseline Serum ◽  
Hydroxyvitamin D ◽  
Direct Measurements ◽  
25 Hydroxyvitamin D

ObjectiveTo determine the relationship between serum total 25-hydroxyvitamin D (25(OH)D), directly measured free 25(OH)D and calculated free 25(OH)D with regard to vitamin D-binding protein (DBP) phenotypes, sex, BMI, age and season, and their interrelationship to vitamin D supplementation.Design, patients and interventionsA randomized controlled trial with 20 000 IU of vitamin D3per week or placebo for 12 months was designed. A total of 472 subjects, 236 in each of the intervention groups, were included in the analyses.Main outcome measuresBaseline serum concentrations and increases in serum total 25(OH)D, directly measured free 25(OH)D, calculated free 25(OH)D and DBP.ResultsSerum total 25(OH)D and DBP concentrations were significantly lower in subjects with the phenotype Gc2/Gc2 compared to phenotypes with the Gc1S allele, and lower in males compared to females. When using directly measured free 25(OH)D, the differences related to DBP phenotypes and sexes were clearly diminished. All calculated free 25(OH)D concentrations were overestimated compared to the directly measured free 25(OH)D. Serum parathyroid hormone showed an inverse correlation with all vitamin D parameters analyzed. The increases after 12 months of vitamin D supplementation were not significantly different for any of the vitamin D parameters regardless of DBP phenotype, sex or age. Supplementation with vitamin D did not affect serum DBP.ConclusionDirect measurements of free 25(OH)D reduce the differences seen in total 25(OH)D between DBP phenotype groups and sexes, probably caused by differences in DBP concentrations. With conditions affecting serum DBP concentrations, direct measurements of free 25(OH)D should be considered.

scholarly journals Influence of vitamin D binding protein polymorphism, demographics and lifestyle factors on vitamin D status of healthy Malaysian pregnant women

2020 ◽  
Author(s):  
Siew-Siew Lee ◽  
King-Hwa Ling ◽  
Maiza Tusimin ◽  
Raman Subramaniam ◽  
Kartini Farah Rahim ◽  
...  
Keyword(s):  
Vitamin D ◽  
Gene Polymorphism ◽  
Pregnant Women ◽  
Binding Protein ◽  
Lifestyle Factors ◽  
Vitamin D Supplementation ◽  
Dietary Vitamin ◽  
Vitamin D Binding Protein ◽  
Significant Positive Association ◽  
Cross Sectional

Abstract Background: Vitamin D deficiency (VDD) has been related to vitamin D binding protein (GC) gene polymorphism, demographics and lifestyle factors in different populations. However, previous studies only focused on demographic and lifestyle factors or genetic factors alone. Therefore, this cross-sectional study aimed to assess the association between GC gene polymorphism, demographics and lifestyle factors with VDD among Malaysian pregnant women.Method: Information on demographic characteristics, dietary vitamin D intake from supplement and food, time spent outdoors, skin type and clothing were collected using questionnaire. Plasma total 25-hydroxyvitamin D (25OHD) levels were measured using a Ultra-High-Performance Chromatography (UHPLC). Maternal GC single nucleotide polymorphisms (SNPs) (rs4588 and rs7041) were determined using restriction fragment length polymorphism (RFLP) technique.Results: Results showed that 50.2% of pregnant women were vitamin D deficient (25OHD <30 nmol/L). VDD (25OHD <30 nmol/L) was significantly associated with age, veiled clothing, maternal vitamin D intakes, from both food and supplements, and GC rs7041(and GC diplotypes). In contrast to previous studies that reported for non-pregnant population, significant positive association was found between CC genotype for SNP GC rs7041, GC 1s-1s and GC If-2 with risk of VDD (25OHD <30 nmol/L). Conclusions: The high prevalence of maternal VDD found in this study suggests the need for urgent development and implementation of vitamin D supplementation or fortification strategies to reduce VDD among pregnant women. The discrepancy in the association between GC rs7041 gene polymorphism and VDD reflects the variation in the factors associated with VDD in pregnancy compared to non-pregnant state

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