Effects of a hypoenergetic diet rich in α-linolenic acid on fatty acid composition of serum phospholipids in overweight and obese patients with metabolic syndrome

Nutrition ◽  
2018 ◽  
Vol 49 ◽  
pp. 74-80 ◽  
Author(s):  
Sarah Egert ◽  
Andrea Baxheinrich ◽  
Young Hee Lee-Barkey ◽  
Diethelm Tschoepe ◽  
Peter Stehle ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Linolenic Acid ◽  
Acid Composition ◽  
Obese Patients ◽  
Serum Phospholipids

scholarly journals Effects of the flavonol quercetin and α-linolenic acid on n-3 PUFA status in metabolically healthy men and women: a randomised, double-blinded, placebo-controlled, crossover trial

2017 ◽  
Vol 117 (5) ◽  
pp. 698-711 ◽  
Author(s):  
Constanze Burak ◽  
Siegfried Wolffram ◽  
Berndt Zur ◽  
Peter Langguth ◽  
Rolf Fimmers ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Linolenic Acid ◽  
Acid Composition ◽  
Crossover Trial ◽  
Men And Women ◽  
Healthy Men ◽  
Metabolically Healthy ◽  
Double Blinded ◽  
Serum Phospholipids

AbstractIncreased dietary intake and tissue status of the long-chain n-3 PUFA, EPA and DHA, is associated with cardiovascular benefits. Epidemiological and animal studies suggest that concomitant nutritive intake of flavonoids may increase the conversion of α-linolenic acid (ALA) to longer-chain n-3 fatty acids EPA and DHA. We investigated the effects of increased ALA intake on fatty acid composition of serum phospholipids and erythrocytes in metabolically healthy men and women and whether fatty acid profiles and ALA conversion were affected by regular quercetin intake or sex. Subjects (n 74) were randomised to receive at least 3·3 g/d ALA with either 190 mg/d quercetin (ALA+quercetin) or placebo (ALA+placebo) in a double-blinded, placebo-controlled, crossover trial with 8-week intervention periods separated by an 8-week washout period. A total of seven subjects dropped out for personal reasons. Data from the remaining sixty-seven subjects (thirty-four males and thirty-three females) were included in the analysis. Both interventions significantly increased serum phospholipid ALA (ALA+placebo: +69·3 %; ALA+quercetin: +55·8 %) and EPA (ALA+placebo: +37·3 %; ALA+quercetin: +25·5 %). ALA + quercetin slightly decreased DHA concentration by 9·3 %. Erythrocyte ALA and EPA significantly increased with both interventions, whereas DHA decreased. Fatty acid composition did not differ between sexes. We found no effect of quercetin. Intake of 3·6 g/d ALA over an 8-week period resulted in increased ALA and EPA, but not DHA, in serum phospholipids and erythrocytes. Neither quercetin supplementation nor sex affected the increment of ALA and relative proportions of n-3 PUFA in serum phospholipids and erythrocytes.

scholarly journals Adipose Fatty Acid Composition and Rate of Incorporation of α-Linolenic Acid Differ between Normal and Lipoprotein Lipase-Deficient Cats

2006 ◽  
Vol 136 (12) ◽  
pp. 2980-2986 ◽  
Author(s):  
Brian C. Veltri ◽  
Robert C. Backus ◽  
Quinton R. Rogers ◽  
Edward J. DePeters
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Linolenic Acid ◽  
Lipoprotein Lipase ◽  
Acid Composition
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