Apolipoprotein A2 −265 T>C polymorphism interacts with dietary fatty acids intake to modulate inflammation in type 2 diabetes mellitus patients

Nutrition ◽  
2017 ◽  
Vol 37 ◽  
pp. 86-91 ◽  
Author(s):  
Laleh Keramat ◽  
Haleh Sadrzadeh-Yeganeh ◽  
Gity Sotoudeh ◽  
Elham Zamani ◽  
Mohammadreza Eshraghian ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Type 2 Diabetes Mellitus ◽  
Dietary Fatty Acids

The interaction between ApoA2 −265T>C polymorphism and dietary fatty acids intake on oxidative stress in patients with type 2 diabetes mellitus

2016 ◽  
Vol 56 (5) ◽  
pp. 1931-1938 ◽  
Author(s):  
Elham Zamani ◽  
Haleh Sadrzadeh-Yeganeh ◽  
Gity Sotoudeh ◽  
Laleh Keramat ◽  
Mohammadreza Eshraghian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Type 2 Diabetes Mellitus ◽  
Dietary Fatty Acids

scholarly journals The effect of OMEGA-3 polyunsaturated fatty acids on ambulatory blood pressure monitoring parameters in patients with type 2 diabetes mellitus and cardiovascular autonomic neuropathy

2019 ◽  
Vol 22 (1) ◽  
pp. 62-69
Author(s):  
Victoria A. Serhiyenko ◽  
Boris N. Mankovsky ◽  
Ludmila М. Serhiyenko ◽  
Aleksandr A. Serhiyenko
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Type 2 Diabetes Mellitus ◽  
Diastolic Blood Pressure ◽  
Blood Pressure Monitoring ◽  
Pressure Monitoring ◽  
Time Index

Background: Cardiovascular autonomic neuropathy (CAN) in type 2 diabetes mellitus (T2DM), which is characterized by lesion of nerve fibers in parasympathetic and sympathetic nervous system is one of the leading causes of heart arrhythmias and an independent risk factor for cardiovascular mortality in patients with T2DM. Therefore, the problem of effective treatment of CAN is particularly relevant. Aims: To analyze the effect of long-chain polyunsaturated fatty acids (-3 PUFAs) on ambulatory blood pressure monitoring parameters in patients with T2DM and CAN. Materials and methods: 36 patients with T2DM and confirmed CAN were divided into two groups. First group received hypoglycemic therapy (n=15, control) for three months; patients in group 2 (n=21) in addition were administered 1 capsule/q.d. of -3 PUFAs for three month. Results: Treatment with -3 PUFAs led to significant decrease of the diastolic blood pressure (DBP) (p0,01), diastolic blood pressure load (p0,05), time index of DBP (p0,05) during the day; DBP (p0,05), diastolic blood pressure load (p0,05), time index of DBP (p0,05), SD DBP (p0,01) during the night (compared to the control group). Conclusions: The study showed that prescription of -3 PUFAs for three month was effective in decreasing diastolic blood pressure and its parameters among patients with T2DM and CAN.

Screening of secondary metabolites, bioactive compounds, in vitro antioxidant, antibacterial, antidiabetic and anti-inflammatory activities of chia seeds (Salvia hispanica L.)

2021 ◽  
pp. 6289-6294
Author(s):  
Saffiya Banu. A ◽  
Sheila John ◽  
Sarah Jane Monica ◽  
Saraswathi. K ◽  
Arumugam. P
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Type 2 Diabetes Mellitus ◽  
Dpph Radical ◽  
Anti Inflammatory

Recent research studies indicate the role of functional foods in preventing the development of complications associated with type 2 diabetes mellitus. Chia seeds are an excellent source of dietary fibre, essential fatty acids, micronutrients and non-nutritive components. The objective of the study was to evaluate the antioxidant, antibacterial, antidiabetic and anti-inflammatory potential of chia seeds. TPC and TFC were estimated using Folin-Ciocalteu Reagent and Alumininum Chloride method. The antioxidant activity was determined using DPPH● radical, ABTS●+ radical, Superoxide (O2-) radical, Fe3+ reducing and phosphomolybdenum reduction assay. Agar well diffusion method was used to determine the antibacterial activity against Escherichia coli, Proteus vulgaris, Shigella flexneri, Micrococcus luteus, Bacillus subtilis and Staphylococcus aureus. Antidiabetic and anti-inflammatory activities were evaluated using alpha amylase inhibition assay and heat induced haemolysis method. Volatile functional compounds were identified using Gas chromatography mass spectrometry. Upon quantification, TPC and TFC were found to be 850.67±14.14µg/mg GAE and 171.21±12.86µg/mg QE. Free radical scavenging activity of chia seeds was ranked in the order of DPPH● radical >ABTS●+ radical > Superoxide (O2-) radical. The capability of chia seeds to function as electron donors was evident through its strong reducing power. With regard to antibacterial activity, maximum inhibition was observed for Staphylococcus aureus, with a zone of inhibition of 31mm at 500µg/mL. Results of antidiabetic assay highlighted the alpha amylase inhibitory action of chia seeds with an IC50 value of 121.46µg/mL. The anti-inflammatory activity of chia seeds increased linearly in a dose dependent manner. GC-MS analysis showed the presence of functionally active compounds such as coumarine, napthoquinone, phytol, fatty acids, flavone and flavone derivatives. Findings of the study highlight that chia seeds have several essential therapeutic properties. Furthermore, clinical studies are required to validate the role of chia seeds in preventing the development of complications associated with type 2 diabetes mellitus.

n-3 Polyunsaturated Fatty Acids in Type 2 Diabetes Mellitus

2019 ◽  
pp. 193-209 ◽  
Author(s):  
Roxana Valdés-Ramos ◽  
Ana Laura Guadarrama-López ◽  
Beatriz Elina Martínez-Carrillo ◽  
Laurence Steven Harbige
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Type 2 Diabetes Mellitus ◽  
Polyunsaturated Fatty Acids

Plasma levels of free fatty acids correlate with type 2 diabetes mellitus

2018 ◽  
Vol 20 (11) ◽  
pp. 2661-2669 ◽  
Author(s):  
Sandro Spiller ◽  
Matthias Blüher ◽  
Ralf Hoffmann
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Type 2 Diabetes Mellitus ◽  
Free Fatty Acids ◽  
Plasma Levels

Postprandial free fatty acids metabolism early in the natural history of type 2 diabetes mellitus

2009 ◽  
Vol 33 (1) ◽  
pp. 56-57
Author(s):  
François N. Lauzière ◽  
Sébastien L. Ménard ◽  
Frédérique Frish ◽  
Pascal Brassard ◽  
Denis Cyr ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Type 2 Diabetes Mellitus ◽  
Natural History ◽  
Free Fatty Acids ◽  
Fatty Acids Metabolism ◽  
History Of
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