Effects of maternal high-fat diet and statin treatment on bone marrow endothelial progenitor cells and cardiovascular risk factors in female mice offspring fed a similar diet

Nutrition ◽  
2017 ◽  
Vol 35 ◽  
pp. 6-13 ◽  
Author(s):  
Maqsood M. Elahi ◽  
Bashir Mnene Matata
Keyword(s):  
Risk Factors ◽  
Bone Marrow ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
High Fat Diet ◽  
Statin Treatment ◽  
High Fat ◽  
Female Mice

scholarly journals Antioxidative Diet Supplementation Reverses High-Fat Diet-Induced Increases of Cardiovascular Risk Factors in Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Hilda Vargas-Robles ◽  
Amelia Rios ◽  
Monica Arellano-Mendoza ◽  
Bruno A. Escalante ◽  
Michael Schnoor
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
High Fat Diet ◽  
Serum Triglyceride ◽  
High Fat ◽  
Daily Consumption ◽  
Beneficial Effects ◽  
Diet Supplementation

Obesity is a worldwide epidemic that is characterized not only by excessive fat deposition but also by systemic microinflammation, high oxidative stress, and increased cardiovascular risk factors. While diets enriched in natural antioxidants showed beneficial effects on oxidative stress, blood pressure, and serum lipid composition, diet supplementation with synthetic antioxidants showed contradictive results. Thus, we tested in C57Bl/6 mice whether a daily dosage of an antioxidative mixture consisting of vitamin C, vitamin E, L-arginine, eicosapentaenoic acid, and docosahexaenoic acid (corabion) would affect cardiovascular risk factors associated with obesity. Obese mice showed increased serum triglyceride and glucose levels and hypertension after eight weeks of being fed a high-fat diet (HFD). Importantly, corabion ameliorated all of these symptoms significantly. Oxidative stress and early signs of systemic microinflammation already developed after two weeks of high-fat diet and were significantly reduced by daily doses of corabion. Of note, the beneficial effects of corabion could not be observed when applying its single antioxidative components suggesting that a combination of various nutrients is required to counteract HFD-induced cardiovascular risk factors. Thus, daily consumption of corabion may be beneficial for the management of obesity-related cardiovascular complications.

scholarly journals Impact of ADMA, endothelial progenitor cells and traditional cardiovascular risk factors on pulse wave velocity among prediabetic individuals

2012 ◽  
Vol 11 (1) ◽  
pp. 141 ◽  
Author(s):  
Ioannis Protopsaltis ◽  
Stefanos Foussas ◽  
Angeliki Angelidi ◽  
Angelos Gritzapis ◽  
Theodoros Ν Sergentanis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Pulse Wave Velocity ◽  
Cardiovascular Risk Factors ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Wave Velocity ◽  
Pulse Wave ◽  
Endothelial Progenitor

scholarly journals Effects of Extra Virgin Olive Oil and Apples Enriched-Dark Chocolate on Endothelial Progenitor Cells in Patients with Cardiovascular Risk Factors: A Randomized Cross-Over Trial

Antioxidants ◽  
2019 ◽  
Vol 8 (4) ◽  
pp. 88 ◽  
Author(s):  
Francesca Felice ◽  
Alessandra Francini ◽  
Valentina Domenici ◽  
Mario Cifelli ◽  
Ester Belardinelli ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Olive Oil ◽  
Cardiovascular Risk Factors ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Virgin Olive Oil ◽  
Extra Virgin Olive Oil ◽  
Dark Chocolate ◽  
Blood Levels

Background: Endothelial dysfunction has been associated to cardiovascular outcomes in patients with cardiovascular risk factors. Circulating endothelial progenitor cells (EPCs) play an important physiological role for their reparative potential of vascular integrity, but are numerically reduced and functionally impaired in patients with cardiovascular risks. This study assesses the effects of Extra Virgin Olive Oil (EVOO) and apple-enriched dark chocolate intake on the blood levels of EPCs. Methods: Thirty volunteers with cardiovascular risk factors, enrolled in a randomised, crossover, four-weeks trial, received a solid dark chocolate bar (40 g/day) containing 10% EVOO or 2.5% dry apples. Urine samples were analyzed for endogenous metabolites. Circulating EPCs levels, clinical data and anthropometric examinations were collected. Results: 26 volunteers (M/F:14/12, 51 ± 9 years of age) completed the study. Comparison of pre-post intervention revealed a significant increase in EPCs levels associated with EVOO-dark chocolate consumption. Most biochemical parameters were not significantly modified by both chocolates. Conclusions: This study shows that a daily consumption of a non fattening dose of dark chocolate enriched with EVOO improves blood levels of EPCs, a well known surrogate biologic marker for endothelial function.

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