Long-term effects of a very-low-carbohydrate weight-loss diet and an isocaloric low-fat diet on bone health in obese adults

Nutrition ◽  
2016 ◽  
Vol 32 (9) ◽  
pp. 1033-1036 ◽  
Author(s):  
Grant D. Brinkworth ◽  
Thomas P. Wycherley ◽  
Manny Noakes ◽  
Jonathan D. Buckley ◽  
Peter M. Clifton
Keyword(s):  
Weight Loss ◽  
Bone Health ◽  
Long Term Effects ◽  
Low Fat ◽  
Obese Adults ◽  
Weight Loss Diet ◽  
Low Fat Diet ◽  
Low Carbohydrate

scholarly journals Long-term effects of a very-low-carbohydrate weight loss diet compared with an isocaloric low-fat diet after 12 mo

2009 ◽  
Vol 90 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Grant D Brinkworth ◽  
Manny Noakes ◽  
Jonathan D Buckley ◽  
Jennifer B Keogh ◽  
Peter M Clifton
Keyword(s):  
Weight Loss ◽  
Long Term Effects ◽  
Low Fat ◽  
Weight Loss Diet ◽  
Low Fat Diet ◽  
Low Carbohydrate

Long-Term Effects of a Very Low-Carbohydrate Weight Loss Diet on Exercise Capacity and Tolerance in Overweight and Obese Adults

2014 ◽  
Vol 33 (4) ◽  
pp. 267-273 ◽  
Author(s):  
Thomas P. Wycherley ◽  
Jonathan D. Buckley ◽  
Manny Noakes ◽  
Peter M. Clifton ◽  
Grant D. Brinkworth
Keyword(s):  
Weight Loss ◽  
Exercise Capacity ◽  
Long Term Effects ◽  
Obese Adults ◽  
Weight Loss Diet ◽  
Low Carbohydrate

scholarly journals Long-term effects of weight loss with a very low carbohydrate and low fat diet on vascular function in overweight and obese patients

2010 ◽  
Vol 267 (5) ◽  
pp. 452-461 ◽  
Author(s):  
T. P. Wycherley ◽  
G. D. Brinkworth ◽  
J. B. Keogh ◽  
M. Noakes ◽  
J. D. Buckley ◽  
...  
Keyword(s):  
Weight Loss ◽  
Vascular Function ◽  
Obese Patients ◽  
Long Term Effects ◽  
Low Fat ◽  
Low Fat Diet ◽  
Low Carbohydrate

Postprandial coagulation activation in overweight individuals after weight loss: Acute and long-term effects of a high-monounsaturated fat diet and a low-fat diet

2014 ◽  
Vol 133 (3) ◽  
pp. 327-333 ◽  
Author(s):  
Else-Marie Bladbjerg ◽  
Thomas M. Larsen ◽  
Anette Due ◽  
Jørgen Jespersen ◽  
Steen Stender ◽  
...  
Keyword(s):  
Weight Loss ◽  
Long Term Effects ◽  
Monounsaturated Fat ◽  
Low Fat ◽  
Coagulation Activation ◽  
Low Fat Diet

scholarly journals Long-term dietary intervention reveals resilience of the gut microbiota despite changes in diet and weight

2020 ◽  
Vol 111 (6) ◽  
pp. 1127-1136 ◽  
Author(s):  
Gabriela K Fragiadakis ◽  
Hannah C Wastyk ◽  
Jennifer L Robinson ◽  
Erica D Sonnenburg ◽  
Justin L Sonnenburg ◽  
...  
Keyword(s):  
Weight Loss ◽  
Human Physiology ◽  
Gut Microbiota ◽  
Dietary Intervention ◽  
Microbiota Composition ◽  
Low Fat ◽  
Low Fat Diet ◽  
Low Carbohydrate ◽  
Taxonomic Changes

Abstract Background With the rising rates of obesity and associated metabolic disorders, there is a growing need for effective long-term weight-loss strategies, coupled with an understanding of how they interface with human physiology. Interest is growing in the potential role of gut microbes as they pertain to responses to different weight-loss diets; however, the ways that diet, the gut microbiota, and long-term weight loss influence one another is not well understood. Objectives Our primary objective was to determine if baseline microbiota composition or diversity was associated with weight-loss success. A secondary objective was to track the longitudinal associations of changes to lower-carbohydrate or lower-fat diets and concomitant weight loss with the composition and diversity of the gut microbiota. Methods We used 16S ribosomal RNA gene amplicon sequencing to profile microbiota composition over a 12-mo period in 49 participants as part of a larger randomized dietary intervention study of participants consuming either a healthy low-carbohydrate or a healthy low-fat diet. Results While baseline microbiota composition was not predictive of weight loss, each diet resulted in substantial changes in the microbiota 3-mo after the start of the intervention; some of these changes were diet specific (14 taxonomic changes specific to the healthy low-carbohydrate diet, 12 taxonomic changes specific to the healthy low-fat diet) and others tracked with weight loss (7 taxonomic changes in both diets). After these initial shifts, the microbiota returned near its original baseline state for the remainder of the intervention, despite participants maintaining their diet and weight loss for the entire study. Conclusions These results suggest a resilience to perturbation of the microbiota's starting profile. When considering the established contribution of obesity-associated microbiotas to weight gain in animal models, microbiota resilience may need to be overcome for long-term alterations to human physiology. This trial was registered at clinicaltrials.gov as NCT01826591.

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