The effect of 12-wk ω-3 fatty acid supplementation on in vivo thalamus glutathione concentration in patients “at risk” for major depression

Nutrition ◽  
2015 ◽  
Vol 31 (10) ◽  
pp. 1247-1254 ◽  
Author(s):  
Shantel L. Duffy ◽  
Jim Lagopoulos ◽  
Nicole Cockayne ◽  
Simon J.G. Lewis ◽  
Ian B. Hickie ◽  
...  
Keyword(s):  
At Risk ◽  
Fatty Acid ◽  
Major Depression ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation ◽  
Glutathione Concentration ◽  
Patients At Risk

scholarly journals Omega-3 fatty acid supplementation delays the progression of neuroblastoma in vivo

2010 ◽  
Vol 128 (7) ◽  
pp. 1703-1711 ◽  
Author(s):  
Helena Gleissman ◽  
Lova Segerström ◽  
Mats Hamberg ◽  
Frida Ponthan ◽  
Magnus Lindskog ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Omega 3 ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation ◽  
Omega 3 Fatty Acid

N-3 Fatty Acid Supplementation Influences Membrane Fatty Acids and Phospholipase A2 Activity in Patients at Risk to Develop Psychosis

2011 ◽  
Vol 26 (S2) ◽  
pp. 1129-1129
Author(s):  
S. Smesny ◽  
B. Milleit ◽  
M. Schäfer ◽  
C. Milleit ◽  
M. Otto ◽  
...  
Keyword(s):  
At Risk ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Negative Symptoms ◽  
Neuronal Damage ◽  
Pufa Supplementation ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation ◽  
Membrane Fatty Acids ◽  
Before And After

IntroductionDecreased levels of polyunsaturated membrane fatty acids (PUFA) and increased activity of cytosolic phospholipase A2 (PLA2) enzymes (key regulating enzymes of membrane remodelling and PUFA availability) are supporting pillars of the “membrane phospholipids concept of schizophrenia”. Assuming that membrane PUFA profile and PLA2 activity are altered during the at risk phase of disorder and influenced by fatty acid supplementation, we investigated PUFA profiles and PLA2 activity simultaneously in ultra high-risk (UHR) subjects before and after (n-3) fatty acids supplementation.MethodIn 81 UHR patients (aged between 13 and 25 years) PUFA levels were assessed in erythrocyte membranes using gas chromatography, and cytosolic PLA2 activity was measured in blood serum using a fluorometric HPTLC-based assay. Measurements were performed before and after a 6 month interval of placebo-controlled supplementation with n-3 fatty acids.ResultsAt baseline significant associations were found between (n-9) and (n-6)-PUFA levels and psychopathology (especially in negative symptoms) assessed by the PANSS according to PACE criteria. (n-3)-PUFA supplementation caused significant changes in (n-3)- and (n-6)-PUFA levels and a significant decrease of PLA2 activity.ConclusionOur results support associations between membrane biochemistry and psychopathology (especially negative symptoms) in people at risk to develop psychosis. Supplementation of n-3 PUFA increases PUFA availability at membrane level and modulates membrane repair and remodelling processes. Assuming that PLA2 activity reflects neuronal damage, PUFA supplementation might unfold neuroprotective effects.

scholarly journals Omega-3 polyunsaturated fatty acid supplementation and white matter changes in major depression

2016 ◽  
Vol 75 ◽  
pp. 65-74 ◽  
Author(s):  
Binod Thapa Chhetry ◽  
Adrienne Hezghia ◽  
Jeffrey M. Miller ◽  
Seonjoo Lee ◽  
Harry Rubin-Falcone ◽  
...  
Keyword(s):  
Fatty Acid ◽  
White Matter ◽  
Major Depression ◽  
Polyunsaturated Fatty Acid ◽  
Omega 3 ◽  
White Matter Changes ◽  
Fatty Acid Supplementation ◽  
Acid Supplementation
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