Short-term effects of ketogenic diet on anthropometric parameters, body fat distribution, and inflammatory cytokine production in GLUT1 deficiency syndrome

Nutrition ◽  
2015 ◽  
Vol 31 (7-8) ◽  
pp. 981-987 ◽  
Author(s):  
Simona Bertoli ◽  
Ilaria Giulini Neri ◽  
Claudia Trentani ◽  
Cinzia Ferraris ◽  
Ramona De Amicis ◽  
...  
Keyword(s):  
Body Fat ◽  
Inflammatory Cytokine ◽  
Cytokine Production ◽  
Fat Distribution ◽  
Deficiency Syndrome ◽  
Short Term ◽  
Anthropometric Parameters ◽  
Inflammatory Cytokine Production ◽  
Glut1 Deficiency ◽  
Glut1 Deficiency Syndrome

scholarly journals Long-Term Effects of a Classic Ketogenic Diet on Ghrelin and Leptin Concentration: A 12-Month Prospective Study in a Cohort of Italian Children and Adults with GLUT1-Deficiency Syndrome and Drug Resistant Epilepsy

Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1716 ◽  
Author(s):  
Ramona De Amicis ◽  
Alessandro Leone ◽  
Chiara Lessa ◽  
Andrea Foppiani ◽  
Simone Ravella ◽  
...  
Keyword(s):  
Body Composition ◽  
Nutritional Status ◽  
Body Fat ◽  
Deficiency Syndrome ◽  
Drug Resistant ◽  
Z Score ◽  
Glut1 Deficiency ◽  
Glut1 Deficiency Syndrome ◽  
Drug Resistant Epilepsy

The classical ketogenic diet (cKD) is an isocaloric, high fat, very low-carbohydrate diet that induces ketosis, strongly influencing leptin and ghrelin regulation. However, not enough is known about the impact of a long-term cKD. This study evaluated the effects of a 12-month cKD on ghrelin and leptin concentrations in children, adolescents and adults affected by the GLUT1-Deficiency Syndrome or drug resistant epilepsy (DRE). We also investigated the relationship between the nutritional status, body composition and ghrelin and leptin variations. We carried out a longitudinal study on 30 patients: Twenty-five children and adolescents (15 females, 8 ± 4 years), and five adults (two females, 34 ± 16 years). After 12-monoths cKD, there were no significant changes in ghrelin and leptin, or in the nutritional status, body fat, glucose and lipid profiles. However, a slight height z-score reduction (from −0.603 ± 1.178 to −0.953 ± 1.354, p ≤ 0.001) and a drop in fasting insulin occurred. We found no correlations between ghrelin changes and nutritional status and body composition, whereas leptin changes correlated positively with variations in the weight z-score and body fat (ρ = 0.4534, p = 0.0341; ρ = 0.5901, p = 0.0135; respectively). These results suggest that a long-term cKD does not change ghrelin and leptin concentrations independently of age and neurological condition.

Reduced reactivity of glucocorticoid suppression of pro-inflammatory cytokine production to acute stress after short-term fasting

2016 ◽  
Vol 71 ◽  
pp. 64
Author(s):  
Luke C. Hanlin ◽  
Jonah Price ◽  
Alexander Fiksdal ◽  
Yuliya I. Kuras ◽  
James R. Mitchell ◽  
...  
Keyword(s):  
Inflammatory Cytokine ◽  
Cytokine Production ◽  
Acute Stress ◽  
Short Term ◽  
Inflammatory Cytokine Production
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