Single pyruvate intake induces blood alkalization and modification of resting metabolism in humans

Nutrition ◽  
2015 ◽  
Vol 31 (3) ◽  
pp. 466-474 ◽  
Author(s):  
Robert A. Olek ◽  
Marcin Luszczyk ◽  
Sylwester Kujach ◽  
Ewa Ziemann ◽  
Magdalena Pieszko ◽  
...  
Keyword(s):  
Resting Metabolism

scholarly journals Quantifying the energetic cost of food quality constraints on resting metabolism to integrate nutritional and metabolic ecology

2021 ◽  
Author(s):  
Thomas Ruiz ◽  
Apostolos‐Manuel Koussoroplis ◽  
Michael Danger ◽  
Jean‐Pierre Aguer ◽  
Nicole Morel‐Desrosiers ◽  
...  
Keyword(s):  
Food Quality ◽  
Energetic Cost ◽  
Metabolic Ecology ◽  
Resting Metabolism

Respiratory responses to air-exposure in the southern rock lobster, Jasus edwardsii (Hutton) (Decapoda:Palinuridae)

1997 ◽  
Vol 48 (8) ◽  
pp. 889 ◽  
Author(s):  
H. Harry Taylor ◽  
Francesca M. Waldron
Keyword(s):  
Heart Rate ◽  
Oxygen Consumption ◽  
Base Excess ◽  
Respiratory Acidosis ◽  
Metabolic Cost ◽  
Excess Oxygen ◽  
Air Exposure ◽  
Water Oxygen ◽  
Jasus Edwardsii ◽  
Resting Metabolism

Air-exposure of settled Jasus edwardsii at 17˚C initially halved oxygen consumption, doubled ventilation frequency and reduced heart rate. During 8 h emersion, oxygen uptake partially recovered, ventilation remained elevated and heart rate was restored. Haemolymph PCO2 increased fourfold, despite the hyperventilation. Branchial gas exchange, initially impaired in air, may improve as the gills drain. Partial anaerobiosis was indicated by elevation of haemolymph [lactate-] to 4.2 mmol L-1. Although haemolymph pH decreased ~0.3 units over 8 h, a base excess compensated all of the metabolic and part of the respiratory acidosis. On return to water, oxygen consumption initially increased to >2.5 times pre-emersion rates while ventilation and heart rates increased further. Most respiratory variables returned to pre-emersion levels within 8 h of re- immersion, but oxygen consumption and heart rate remained elevated for 24 h. The excess oxygen consumption over resting rate during 24 h recovery in water indicated a metabolic cost of 8 h emersion equivalent to 10 h resting metabolism in water. These responses contrast with better acid–base compensation previously reported for undisturbed Homarus gammarus in air and worse tolerance of air-exposure by Panulirus argus

Abstract 104: Metabolic Effect of Temperature Manipulation in Healthy Individuals

Circulation ◽  
2019 ◽  
Vol 140 (Suppl_2) ◽  
Author(s):  
Jon C Rittenberger ◽  
Katharyn Flickinger ◽  
David Hopkins ◽  
Jonathan Elmer ◽  
Frank Guyette ◽  
...  
Keyword(s):  
Energy Expenditure ◽  
Core Temperature ◽  
Vital Signs ◽  
Effect Of Temperature ◽  
Healthy Individuals ◽  
Richmond Agitation Sedation Scale ◽  
Resting Metabolism ◽  
Temperature Manipulation ◽  
Dexmedetomidine Infusion ◽  
Median Height

Introduction: Temperature manipulation to decrease metabolism is commonly after acute brain injury. Preclinical data suggest metabolism decreases 7-8% for each degree C drop in core temperature. We hypothesized similar results would be found in healthy individuals. Methods: Following informed consent and physical screening, we administered a 1mcg/kg bolus of dexmedetomidine followed by 20cc/kg of cold (4C) saline bolus. We cooled subjects using surface pads (emcools (Austria)). Dexmedetomidine infusion was titrated to effect (max dose <1.5mcg/kg/hr). We recorded vital signs, Richmond Agitation Sedation Scale, Bedside Shivering Assessment Scale and sensation of cold every 15 minutes. We measured resting metabolism at baseline and after each 1 C decrease in temperature thereafter using indirect calorimetry and a ventilated canopy system. We analyzed data using analysis of variance. Results: Median age in the 9 enrolled subjects was 30 (SD 10) years and most (78%) were male. Median height was 173 (IQR 168, 180) cm and median weight was 77 (IQR 72, 83) kg. Baseline VO2 was 3.4 (IQR 3.0, 3.8) ml/kg/min and baseline energy expenditure was 1692 (IQR 1579, 1845) kcal/day. Both VO2 and energy expenditure decreased with core temperature (p=0.017 and p=0.027) (Table). Conclusion: Metabolic rate decreases with core temperature manipulation. The largest change occurs between 37C and 36C with smaller changes thereafter.

Abstract 015: Regulation of Resting Metabolism by the Angiotensin AT 2 Receptor

Hypertension ◽  
2014 ◽  
Vol 64 (suppl_1) ◽  
Author(s):  
Nicole K Littlejohn ◽  
Benjamin J Weidemann ◽  
Nicole A Pearson ◽  
Kathleen R Markan ◽  
Matthew J Potthoff ◽  
...  
Keyword(s):  
Energy Homeostasis ◽  
Uncoupling Protein ◽  
Resting Metabolic Rate ◽  
Renin Angiotensin System ◽  
Mrna Levels ◽  
Interscapular Brown Adipose Tissue ◽  
Normal Number ◽  
Human Renin ◽  
Brown Adipose ◽  
Resting Metabolism

The renin-angiotensin system (RAS) positively correlates with obesity, and contributes to energy homeostasis through opposing actions in the brain and adipose. We hypothesize that site- and receptor-specific modulation may represent a novel therapeutic target for obesity. Transgenic “sRA” mice exhibit brain-specific RAS hyperactivity through expression of human renin in neurons (synapsin promoter) and human angiotensinogen via its own promoter. Previously we documented that sRA mice exhibit a suppressed circulating RAS, and an elevated resting metabolic rate (RMR) that is sensitive to replacement of circulating angiotensin II or the AT 2 receptor (AT 2 R) agonist, CGP-42112a (CGP, 100 ng/kg/min, s.c.). sRA mice consume more food than littermate controls (con n=7, 12.98±0.65 vs sRA n=8, 15.41±0.70 g/d, P<0.05), but because of a major suppression of digestive efficiency (con 77.6±2.3 vs sRA 59.3±4.7 % consumed, P<0.05), sRA mice absorb a normal number of calories (con 10.04±0.50 vs sRA 9.07±0.76 kcal/d). Chronic CGP had no effect on total daily caloric absorption (con+CGP n=7, 9.83±0.95 vs sRA+CGP n=5, 9.32±0.80 kcal/d); however CGP appears to disproportionately increase weight gain in sRA mice (vehicle +0.33±0.49 vs CGP +1.54±0.47 g/8 wks, P=0.27) compared to control mice (vehicle +2.12±1.00 vs CGP +2.47±0.73 g/8 wks, P=0.73), consistent with a suppression of energy expenditure by CGP. Given the increased RMR and core temperature in sRA mice, we next examined the expression of uncoupling protein-1 (UCP1) content of thermogenic adipose tissues by Western blot (all n=3, vs perilipin). Interscapular brown adipose tissue UCP1 was unchanged in sRA mice (94±6%), and weakly suppressed by CGP treatment (84±4% of sRA). Inguinal adipose UCP1 was increased in sRA mice (198±13%), and this was suppressed by CGP treatment (72±9% of sRA). UCP1 mRNA levels paralleled protein in both fat types. Cultured adipocytes from 4 day old AT 2 -deficient mice exhibited increased UCP1 protein vs littermate controls (190%). Further, CGP (10 nM) reduced UCP1 in control adipocytes (by 30%). These data support a suppressive action of AT 2 R upon RMR most likely through UCP1. Inguinal adipose AT 2 R may therefore contribute to obesity through suppression of RMR.

Gill and Body Surface Areas of the Carp in relation to Body Mass, With Special Reference To The Metabolism-Size Relationship

1985 ◽  
Vol 117 (1) ◽  
pp. 1-14 ◽  
Author(s):  
SHIN OIKAWA ◽  
YASUO ITAZAWA
Keyword(s):  
Special Reference ◽  
Body Mass ◽  
Body Surface ◽  
Larval Stage ◽  
The Body ◽  
Positive Allometry ◽  
Surface Areas ◽  
Gill Area ◽  
Resting Metabolism ◽  
The Relationship

The relationships of resting metabolism per unit mass of body to gill and body surface areas were examined by measuring gill, body surface and fin areas of carp ranging from 0.0016 to 2250g. There was a triphasic allometry for the relationship between gill area and body mass: during the prelarval (0.0016–0.003 g) and postlarval (0.003–0.2g) stages there was a positive allometry (slopes of 7.066 and 1.222, respectively), during the juvenile and later stages (0.2–2250 g) there was a negative allometry with a slope of 0.794. There was a diphasic negative allometry for the relationship between surface area of the body or the fins and body mass, with a slope of 0.596 or 0.523 during the larval stage and 0.664 or 0.724 during the juvenile and later stages, respectively. Except for the 3rd phase (juvenile to adult) of gill area, these slopes were significantly different (P&lt;0.01) from the slope for the relationship between resting metabolism and body mass of intact carp (0.84; value from Winberg, 1956). It is considered, therefore, that gill, body surface and fin areas do not directly regulate the resting metabolism of the fish, in the larval stage at least.

scholarly journals Effect of menstrual cycle on resting metabolism: A systematic review and meta-analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0236025 ◽  
Author(s):  
Melissa J. Benton ◽  
Andrea M. Hutchins ◽  
J. Jay Dawes
Keyword(s):  
Systematic Review ◽  
Menstrual Cycle ◽  
Meta Analysis ◽  
Resting Metabolism
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