Distinct metabolic pathways trigger adipocyte fat accumulation induced by high-carbohydrate and high-fat diets

Nutrition ◽  
2014 ◽  
Vol 30 (10) ◽  
pp. 1138-1143 ◽  
Author(s):  
Adaliene Versiani Matos Ferreira ◽  
Zélia Menezes-Garcia ◽  
Jonas Baeta Viana ◽  
Érica Guilhen Mário ◽  
Leida Maria Botion
Keyword(s):  
Metabolic Pathways ◽  
High Fat ◽  
Fat Accumulation ◽  
High Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets

Eisenia bicyclis Inhibits Body Weight Gain and Fat Accumulation Induced by High-Fat Diets in Mice

2010 ◽  
Vol 15 (4) ◽  
pp. 262-266 ◽  
Author(s):  
Won-Hee Choi ◽  
Ji-Yun Ahn ◽  
Sun-A Kim ◽  
Tae-Wan Kim ◽  
Tae-Youl Ha
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
Body Weight Gain ◽  
High Fat ◽  
Eisenia Bicyclis ◽  
Fat Accumulation ◽  
High Fat Diets ◽  
Fat Diets

Effects of hyperthyroidism, epinephrine, and diet on heart lipoprotein lipase activity

1964 ◽  
Vol 206 (3) ◽  
pp. 603-609 ◽  
Author(s):  
Adawia A. Alousi ◽  
Samuel Mallov
Keyword(s):  
Lipoprotein Lipase ◽  
Heart Cells ◽  
Lipoprotein Lipase Activity ◽  
High Fat ◽  
Prolonged Fasting ◽  
High Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets ◽  
Cellular Components

Rats were fasted for several days, placed on diets high in carbohydrate, fat, or containing iodinated casein so as to produce hyperthyroidism, or were chronically injected with epinephrine. Lipoprotein lipase (LPL) activities of homogenates of the hearts of these animals were determined. Significant increases in LPL activity occurred in thyrotoxic animals, in rats receiving epinephrine injections chronically, or after prolonged fasting, while significant lowering of cardiac LPL activity was observed in rats on the high-carbohydrate or high-fat diets. Single doses of fat or single injections of epinephrine had no effect. Addition of epinephrine or of triiodothyronine to heart slices or homogenates in vitro caused no LPL increases. It is postulated that adaptive changes in cardiac LPL activity may occur in response to altered needs for utilization of fatty acids by the heart. Microsomal fractions of heart cells had the highest specific LPL activities, suggesting synthesis of the enzyme by these cellular components, or activity of the enzyme at the endoplasmic reticulum.

scholarly journals Maternal and Post-weaning High-Fat Diets Produce Distinct DNA Methylation Patterns in Hepatic Metabolic Pathways within Specific Genomic Contexts

2019 ◽  
Vol 20 (13) ◽  
pp. 3229 ◽  
Author(s):  
Moody ◽  
Wang ◽  
Jung ◽  
Chen ◽  
Pan
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Metabolic Pathways ◽  
Expression Patterns ◽  
Sprague Dawley ◽  
High Fat ◽  
Differentially Methylated Genes ◽  
High Fat Diets ◽  
Diet Intake ◽  
Fat Diets

Calorie-dense high-fat diets (HF) are associated with detrimental health outcomes, including obesity, cardiovascular disease, and diabetes. Both pre- and post-natal HF diets have been hypothesized to negatively impact long-term metabolic health via epigenetic mechanisms. To understand how the timing of HF diet intake impacts DNA methylation and metabolism, male Sprague–Dawley rats were exposed to either maternal HF (MHF) or post-weaning HF diet (PHF). At post-natal week 12, PHF rats had similar body weights but greater hepatic lipid accumulation compared to the MHF rats. Genome-wide DNA methylation was evaluated, and analysis revealed 1744 differentially methylation regions (DMRs) between the groups with the majority of the DMR located outside of gene-coding regions. Within differentially methylated genes (DMGs), intragenic DNA methylation closer to the transcription start site was associated with lower gene expression, whereas DNA methylation further downstream was positively correlated with gene expression. The insulin and phosphatidylinositol (PI) signaling pathways were enriched with 25 DMRs that were associated with 20 DMGs, including PI3 kinase (Pi3k), pyruvate kinase (Pklr), and phosphodiesterase 3 (Pde3). Together, these results suggest that the timing of HF diet intake determines DNA methylation and gene expression patterns in hepatic metabolic pathways that target specific genomic contexts.

Effects of Adrenalectomy on Energy Balance in Obese (ob/ob) Mice Fed High Carbohydrate or High Fat Diets

1987 ◽  
Vol 117 (6) ◽  
pp. 1115-1120 ◽  
Author(s):  
Colleen K. Grogan ◽  
Hye-Kyung Kim ◽  
Dale R. Romsos
Keyword(s):  
Energy Balance ◽  
High Fat ◽  
High Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Dietary Folic Acid and Fat Alter Metabolism of Multiple Vitamins in Mice

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1778-1778
Author(s):  
Keri Barron ◽  
Natalia Krupenko
Keyword(s):  
Folic Acid ◽  
Vitamin A ◽  
Metabolic Pathways ◽  
Vitamin B6 ◽  
High Fat ◽  
Low Fat ◽  
Funding Sources ◽  
Low Fat Diet ◽  
High Fat Diets ◽  
Fat Diets

Abstract Objectives To determine how low and high folic acid (FA) intake, combined with either low or high-fat diets, affects other vitamins in mouse liver and plasma. Methods C57BL/6NHsd mice were placed on one of six diets at weaning and maintained for 16 weeks. The diets varied in their fat content and FA levels: low fat (14% kcal from fat) vs high fat (58% kcal from fat) with 3 different FA levels- 0 ppm FA (FD), 2 ppm FA (Ctrl), 12 ppm (FS). Diets were matched for all other vitamins and minerals. Untargeted metabolomics analysis of plasma and snap-frozen liver samples was conducted at Metabolon®. Results In liver, excess dietary folic acid on a low-fat diet resulted in significantly increased levels of pantothenate, α-tocopherol, FA and several folate metabolites. When FA was over-supplemented in combination with a high fat (HF) diet, α-tocopherol was increased along with several nicotinate and pantothenate metabolites. Interestingly, the HF-FD and -FS diets demonstrated similar effects. These diets resulted in significantly decreased levels of riboflavin, thiamine, vitamin A, and vitamin B6 metabolites while increasing levels of pantetheine metabolites. In plasma, fewer changes with significant differences were observed when mice were fed HF diets. Several nicotinate metabolites were significantly elevated due to the FD diet with no change due to FS. Additionally, there were no changes in pantothenate or riboflavin in the plasma. Interestingly, the HF- FD and -FS diets induced similar responses but in opposite directions in plasma vs liver. The plasma levels of thiamine, vitamin A, and vitamin B6 metabolites were all significantly increased due to both low and high FA, whereas in the liver they were decreased. Additionally, no changes in α-tocopherol were seen in plasma, but the HF-FD diet raised γ/β-tocopherol levels over 2-fold despite equal amounts of vitamin E among all diets. Conclusions Untargeted metabolomic analysis revealed that diets with too high or too low folate affect other vitamins both in liver and plasma. These effects were further modulated by dietary fat levels. The HF-FD and -FS diets had significant impact on vitamins A, B1, B2, B3, B5, B6, B9 and E, along with their related derivatives, which may have serious implications for multiple metabolic pathways. Funding Sources NIH.

The effects of high-carbohydrate and high-fat diets on the serum lipid and lipoprotein concentrations of endurance athletes

Metabolism ◽  
1984 ◽  
Vol 33 (11) ◽  
pp. 1003-1010 ◽  
Author(s):  
Paul D. Thompson ◽  
Eileen M. Cullinane ◽  
Ruth Eshleman ◽  
Mark A. Kantor ◽  
Peter N. Herbert
Keyword(s):  
Serum Lipid ◽  
Endurance Athletes ◽  
High Fat ◽  
High Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets

Comparison of the Effects on Insulin Sensitivity of High Carbohydrate and High Fat Diets in Normal Subjects*

1991 ◽  
Vol 72 (2) ◽  
pp. 432-437 ◽  
Author(s):  
MARK BORKMAN ◽  
LESLEY V. CAMPBELL ◽  
DONALD J. CHISHOLM ◽  
LEONARD H. STORLIEN
Keyword(s):  
Insulin Sensitivity ◽  
Normal Subjects ◽  
High Fat ◽  
High Carbohydrate ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Comparison of maternal isocaloric high carbohydrate and high fat diets on osteogenic and adipogenic genes expression in adolescent mice offspring

2016 ◽  
Vol 13 (1) ◽  
Author(s):  
Seyedeh Neda Mousavi ◽  
Fariba Koohdani ◽  
Farzad Shidfar ◽  
Mohamadreza Baghaban Eslaminejad
Keyword(s):  
High Fat ◽  
High Carbohydrate ◽  
Genes Expression ◽  
High Fat Diets ◽  
Fat Diets
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