Long-term effects of a ketogenic diet on body composition and bone mineralization in GLUT-1 deficiency syndrome: A case series

Nutrition ◽  
2014 ◽  
Vol 30 (6) ◽  
pp. 726-728 ◽  
Author(s):  
Simona Bertoli ◽  
Claudia Trentani ◽  
Cinzia Ferraris ◽  
Valentina De Giorgis ◽  
Pierangelo Veggiotti ◽  
...  
2019 ◽  
Vol 29 (8) ◽  
pp. 884
Author(s):  
Cinzia Ferraris ◽  
Valentina De Giorgis ◽  
Ilaria Brambilla ◽  
Monica Guglielmetti ◽  
Claudia Trentani ◽  
...  

Author(s):  
Stefanie M.P. Kouwenhoven ◽  
Nadja Antl ◽  
Martijn J.J. Finken ◽  
Jos W.R. Twisk ◽  
Eline M. van der Beek ◽  
...  

2001 ◽  
Vol 16 (3) ◽  
pp. 186-190 ◽  
Author(s):  
K.N. Roy Chengappa ◽  
J. Levine ◽  
D. Rathore ◽  
H. Parepally ◽  
R. Atzert

SummaryTopiramate is an antiepileptic agent, which is being investigated as a mood-stabilizer. Three obese individuals with DSM-IV bipolar I disorder and type II diabetes mellitus received topiramate treatment in combination with antipsychotics and valproate or carbamazepine. In addition to improved mood stability, these individuals lost between 16 to 20.5% of their pre-topiramate body weight and also achieved significant glycemic control.


Nutrients ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1716 ◽  
Author(s):  
Ramona De Amicis ◽  
Alessandro Leone ◽  
Chiara Lessa ◽  
Andrea Foppiani ◽  
Simone Ravella ◽  
...  

The classical ketogenic diet (cKD) is an isocaloric, high fat, very low-carbohydrate diet that induces ketosis, strongly influencing leptin and ghrelin regulation. However, not enough is known about the impact of a long-term cKD. This study evaluated the effects of a 12-month cKD on ghrelin and leptin concentrations in children, adolescents and adults affected by the GLUT1-Deficiency Syndrome or drug resistant epilepsy (DRE). We also investigated the relationship between the nutritional status, body composition and ghrelin and leptin variations. We carried out a longitudinal study on 30 patients: Twenty-five children and adolescents (15 females, 8 ± 4 years), and five adults (two females, 34 ± 16 years). After 12-monoths cKD, there were no significant changes in ghrelin and leptin, or in the nutritional status, body fat, glucose and lipid profiles. However, a slight height z-score reduction (from −0.603 ± 1.178 to −0.953 ± 1.354, p ≤ 0.001) and a drop in fasting insulin occurred. We found no correlations between ghrelin changes and nutritional status and body composition, whereas leptin changes correlated positively with variations in the weight z-score and body fat (ρ = 0.4534, p = 0.0341; ρ = 0.5901, p = 0.0135; respectively). These results suggest that a long-term cKD does not change ghrelin and leptin concentrations independently of age and neurological condition.


2019 ◽  
Vol 4 (4) ◽  
pp. 2473011419S0014
Author(s):  
Jun Young Choi ◽  
Min Jin Kim ◽  
Jin Soo Suh

Category: Midfoot/Forefoot Introduction/Purpose: Several conservative treatment methods, from intrinsic muscle exercises to orthoses, including insoles or specially designed shoes, have been introduced for pediatric flexible flat foot (PFFF). However, the structural effects of orthoses use remain unclear because the normal physiological maturation of the medial longitudinal arch cannot be ruled out. Methods: A comprehensive literature search using five databases, namely MEDLINE, the Cochrane Library, Scopus, the Web of Science, and EMBASE, was performed for pertinent articles published before March 30, 2018. Studies with quantitative data on the effects of the long-term use of orthoses for PFFF were included. The search strategy was adapted as appropriate for all other databases searched considering the differences in indexing terms and search syntax for each database. Results: All studies, including randomized controlled trials or prospective cohort studies, could not prove the estimated effects of orthoses on the medial longitudinal arch. However, they revealed that flexible flat feet in young children slowly improved with growth, regardless of the type of footwear used. However, three of four studies, which were case series, revealed that positive long-term effects could be achieved using orthoses. Conclusion: There is no strong evidence that the long-term use of orthoses improved the structural problem of PFFF.


2018 ◽  
Vol 37 (6) ◽  
pp. 2246-2251 ◽  
Author(s):  
Nicole Heussinger ◽  
Adela Della Marina ◽  
Andreas Beyerlein ◽  
Baerbel Leiendecker ◽  
Sofia Hermann-Alves ◽  
...  

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