Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient

Nutrition ◽  
2012 ◽  
Vol 28 (11-12) ◽  
pp. 1200-1203 ◽  
Author(s):  
Mario D. Cordero ◽  
David Cotán ◽  
Yaiza del-Pozo-Martín ◽  
Angel M. Carrión ◽  
Manuel de Miguel ◽  
...  
Keyword(s):  
Coenzyme Q10 ◽  
Mononuclear Cells ◽  
Clinical Symptoms ◽  
Fibromyalgia Patient ◽  
Blood Mononuclear Cells ◽  
Coenzyme Q10 Supplementation

scholarly journals RNA-seq of peripheral blood mononuclear cells of congenital generalized lipodystrophy type 2 patients

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Yen-Hua Huang ◽  
Tzu-Chien Su ◽  
Chung-Hsing Wang ◽  
Siew-Lee Wong ◽  
Yin-Hsiu Chien ◽  
...  
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Clinical Symptoms ◽  
Expression Patterns ◽  
Rna Seq ◽  
Peripheral Blood Mononuclear ◽  
Congenital Generalized Lipodystrophy ◽  
Blood Mononuclear Cells

AbstractIllumina RNA-seq analysis was used to characterize the whole transcriptomes of peripheral blood mononuclear cells (PBMCs) from patients with congenital generalized lipodystrophy. RNA-seq information for seven patients with type 2 congenital generalized lipodystrophy (CGL2; Berardinelli-Seip congenital lipodystrophy, BSCL2) was obtained and compared with similar information for seven age- and sex-matched healthy control subjects. All seven CGL2 patients carried biallelic pathogenic mutations affecting the BSCL2 gene and had clinical symptoms of varying severity. The findings provide the whole-transcriptome signatures of PBMCs of CGL2 patients, allowing further exploration of gene expression patterns/signatures associated with the various clinical symptoms of patients with this disease.

scholarly journals Determination of Coenzyme Q10 Status in Blood Mononuclear Cells, Skeletal Muscle, and Plasma by HPLC with Di-Propoxy-Coenzyme Q10 as an Internal Standard

2005 ◽  
Vol 51 (12) ◽  
pp. 2380-2382 ◽  
Author(s):  
Andrew J Duncan ◽  
Simon JR Heales ◽  
Kevin Mills ◽  
Simon Eaton ◽  
John M Land ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Coenzyme Q10 ◽  
Mononuclear Cells ◽  
Internal Standard ◽  
Blood Mononuclear Cells

scholarly journals Clinical Symptoms in Fibromyalgia Are Better Associated to Lipid Peroxidation Levels in Blood Mononuclear Cells Rather than in Plasma

PLoS ONE ◽  
2011 ◽  
Vol 6 (10) ◽  
pp. e26915 ◽  
Author(s):  
Mario D. Cordero ◽  
Elísabet Alcocer-Gómez ◽  
Francisco J. Cano-García ◽  
Manuel De Miguel ◽  
Angel M. Carrión ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Mononuclear Cells ◽  
Clinical Symptoms ◽  
Blood Mononuclear Cells

scholarly journals Coenzyme Q10 Treatment Monitoring in Different Human Biological Samples

Antioxidants ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 979
Author(s):  
Abraham J. Paredes-Fuentes ◽  
Raquel Montero ◽  
Anna Codina ◽  
Cristina Jou ◽  
Guerau Fernández ◽  
...  
Keyword(s):  
Coenzyme Q10 ◽  
Biological Samples ◽  
Blood Cells ◽  
Mononuclear Cells ◽  
Treatment Monitoring ◽  
Plasma Samples ◽  
Healthy Male ◽  
Blood Mononuclear Cells ◽  
Before And After ◽  
The One

Coenzyme Q10 (CoQ) treatment monitoring is a matter of debate since CoQ distribution from plasma to blood cells and tissues is not fully understood. We aimed to analyze the CoQ levels in a wide set of human biological samples (plasma, blood mononuclear cells (BMCs), platelets, urinary cells, and skeletal muscle) from a group of 11 healthy male runners before and after CoQ supplementation. The CoQ content in the different samples was analyzed by HPLC coupled to electrochemical detection. No significant differences were observed in the CoQ levels measured in the BMCs, platelets, and urine after the one-month treatment period. Plasma CoQ (expressed in absolute values and values relative to total cholesterol) significantly increased after CoQ supplementation (p = 0.003 in both cases), and the increase in CoQ in muscle approached significance (p = 0.074). CoQ levels were increased in the plasma of all supplemented subjects, and muscle CoQ levels were increased in 8 out of 10 supplemented subjects. In conclusion, the analysis of CoQ in plasma samples seems to be the best surrogate biomarker for CoQ treatment monitoring. Moreover, oral CoQ administration was effective for increasing muscle CoQ concentrations in most subjects.

scholarly journals Chromatin from Peripheral Blood Mononuclear Cells as Biomarkers for Epigenetic Abnormalities in Schizophrenia

2009 ◽  
Vol 2009 ◽  
pp. 1-4 ◽  
Author(s):  
David P. Gavin ◽  
Rajiv P. Sharma
Keyword(s):  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Clinical Symptoms ◽  
Mental Illnesses ◽  
Mood Stabilizers ◽  
Peripheral Blood Mononuclear ◽  
Reliable Model ◽  
Blood Mononuclear Cells ◽  
Hormonal Fluctuations

Background. Studies have implicated abnormalities in epigenetic gene regulation in schizophrenia. Presentation. We hypothesize that identifying abnormalities in chromatin structure and the epigenetic machinery in peripheral blood mononuclear cells (PBMC) from schizophrenia patients could (a) help characterize a subset of schizophrenia patients and (b) lead to targeted pharmacological interventions. Testing. Investigate the relationship between clinical symptoms, demographics, hormonal fluctuations, substance abuse, disease characteristics across the major mental illnesses, and epigenetic parameters in PBMC. In addition, examine the effects of individual antipsychotics, mood stabilizers, as well as experimental agents both as clinically prescribed as well as in cultured PBMC to understand the effects of these agents on chromatin. Implications. If PBMC could serve as a reliable model of overall epigenetic mechanisms then this could lead to a “biomarker” approach to revealing pathological chromatin state in schizophrenia. This approach may provide an informed method for selecting chromatin modifying agents for psychiatric disorders.

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