Effects of supplemental dietary arginine on the exogenous advanced glycosylation end product–induced interleukin-23/interleukin-17 immune response in rats

Nutrition ◽  
2012 ◽  
Vol 28 (10) ◽  
pp. 1063-1067 ◽  
Author(s):  
Chiu-Li Yeh ◽  
Ya-Mei Hu ◽  
Jun-Jen Liu ◽  
Wei-Jao Chen ◽  
Sung-Ling Yeh
Keyword(s):  
Immune Response ◽  
Interleukin 17 ◽  
Interleukin 23 ◽  
Advanced Glycosylation

scholarly journals The Koala Immune Response to Chlamydial Infection and Vaccine Development—Advancing Our Immunological Understanding

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 380
Author(s):  
Bonnie L Quigley ◽  
Peter Timms
Keyword(s):  
Immune Response ◽  
Chlamydial Infection ◽  
Vaccine Development ◽  
Interleukin 17 ◽  
Phascolarctos Cinereus ◽  
Post Vaccination ◽  
Research Systems ◽  
Cytokine Levels ◽  
Nucleic Acid Assay ◽  
Immunological Research

Chlamydia is a significant pathogen for many species, including the much-loved Australian marsupial, the koala (Phascolarctos cinereus). To combat this situation, focused research has gone into the development and refinement of a chlamydial vaccine for koalas. The foundation of this process has involved characterising the immune response of koalas to both natural chlamydial infection as well as vaccination. From parallels in human and mouse research, it is well-established that an effective anti-chlamydial response will involve a balance of cell-mediated Th1 responses involving interferon-gamma (IFN-γ), humoral Th2 responses involving systemic IgG and mucosal IgA, and inflammatory Th17 responses involving interleukin 17 (IL-17) and neutrophils. Characterisation of koalas with chlamydial disease has shown increased expression within all three of these major immunological pathways and monitoring of koalas’ post-vaccination has detected further enhancements to these key pathways. These findings offer optimism that a chlamydial vaccine for wider distribution to koalas is not far off. Recent advances in marsupial genetic knowledge and general nucleic acid assay technology have moved koala immunological research a step closer to other mammalian research systems. However, koala-specific reagents to directly assay cytokine levels and cell-surface markers are still needed to progress our understanding of koala immunology.

scholarly journals Proteomic characterisations of ulcerative colitis endoscopic biopsies associate with clinically relevant histological measurements of disease severity

2021 ◽  
pp. jclinpath-2021-207718
Author(s):  
Aaron M Gruver ◽  
Matt D Westfall ◽  
Bradley L Ackermann ◽  
Salisha Hill ◽  
Ryan D Morrison ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Accuracy Assessment ◽  
Interleukin 2 ◽  
Proteome Analysis ◽  
Scoring Systems ◽  
Cell Junction ◽  
Interleukin 17 ◽  
Gamma Chain ◽  
Novel Approach ◽  
Interleukin 23

Aims and methodsAccurate protein measurements using formalin-fixed biopsies are needed to improve disease characterisation. This feasibility study used targeted and global mass spectrometry (MS) to interrogate a spectrum of disease severities using 19 ulcerative colitis (UC) biopsies.ResultsTargeted assays for CD8, CD19, CD132 (interleukin-2 receptor subunit gamma/common cytokine receptor gamma chain), FOXP3 (forkhead box P3) and IL17RA (interleukin 17 receptor A) were successful; however, assays for IL17A (interleukin 17A), IL23 (p19) (interleukin 23, alpha subunit p19) and IL23R (interleukin 23 receptor) did not permit target detection. Global proteome analysis (4200 total proteins) was performed to identify pathways associated with UC progression. Positive correlation was observed between histological scores indicating active colitis and neutrophil-related measurements (R2=0.42–0.72); inverse relationships were detected with cell junction targets (R2=0.49–0.71) and β-catenin (R2=0.51–0.55) attributed to crypt disruption. An exploratory accuracy assessment with Geboes Score and Robarts Histopathology Index cut-offs produced sensitivities/specificities of 72.7%/75.0% and 100.0%/81.8%, respectively.ConclusionsPathologist-guided MS assessments provide a complementary approach to histological scoring systems. Additional studies are indicated to verify the utility of this novel approach.

The interleukin-23/interleukin-17 immune axis as a promising new target in the treatment of spondyloarthritis

2014 ◽  
Vol 26 (4) ◽  
pp. 361-370 ◽  
Author(s):  
Nataliya Yeremenko ◽  
Jacqueline E. Paramarta ◽  
Dominique Baeten
Keyword(s):  
Interleukin 17 ◽  
Interleukin 23

Serum interleukin 17, interleukin 23, and interleukin 10 values in children with atopic eczema/dermatitis syndrome (AEDS): Association with clinical severity and phenotype

2015 ◽  
Vol 36 (1) ◽  
pp. 74-81 ◽  
Author(s):  
Salvatore Leonardi ◽  
Caterina Cuppari ◽  
Sara Manti ◽  
Martina Filippelli ◽  
Giuseppe Fabio Parisi ◽  
...  
Keyword(s):  
Atopic Eczema ◽  
Interleukin 10 ◽  
Clinical Severity ◽  
Interleukin 17 ◽  
Interleukin 23

scholarly journals Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation

Immunity ◽  
2015 ◽  
Vol 43 (4) ◽  
pp. 739-750 ◽  
Author(s):  
Joseph R. Maxwell ◽  
Yu Zhang ◽  
William A. Brown ◽  
Carole L. Smith ◽  
Fergus R. Byrne ◽  
...  
Keyword(s):  
Interleukin 17 ◽  
Interleukin 23
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