scholarly journals Effects of high-fat diet on plasma lipids, adiposity, and inflammatory markers in ovariectomized C57BL/6 mice

Nutrition ◽  
2012 ◽  
Vol 28 (3) ◽  
pp. 316-323 ◽  
Author(s):  
Antonio Ludgero-Correia ◽  
Marcia B. Aguila ◽  
Carlos A. Mandarim-de-Lacerda ◽  
Tatiane S. Faria
Keyword(s):  
High Fat Diet ◽  
Inflammatory Markers ◽  
Plasma Lipids ◽  
High Fat

scholarly journals Effect of high fat diet on inflammatory markers and bone morphological microstructure in growing male mice

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Misung Kim ◽  
Woori Na ◽  
Hanlla Kim ◽  
Eunhye Park ◽  
Hyun-A Lee ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Inflammatory Markers ◽  
Male Mice ◽  
High Fat

Effect of dietary cholesterol in a high-fat diet rich in oleic acid and in a NCEP-I diet on plasma lipids and HDL binding to peripheral granulocytes

1994 ◽  
Vol 109 (1-2) ◽  
pp. 144
Author(s):  
F. Pe´rez-Jime´nez ◽  
J. Lo´pez-Miranda ◽  
J. Trujillo ◽  
A. Blanco-Molina ◽  
J. Blanco ◽  
...  
Keyword(s):  
Oleic Acid ◽  
High Fat Diet ◽  
Plasma Lipids ◽  
Dietary Cholesterol ◽  
High Fat

A 3-Week, Low-Carbohydrate, High-Fat Diet Improves Multiple Serum Inflammatory Markers in Endurance-Trained Males

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Hunter S. Waldman ◽  
Alexander J. Heatherly ◽  
Lauren G. Killen ◽  
Angela Hollingsworth ◽  
Yunsuk Koh ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Inflammatory Markers ◽  
High Fat ◽  
Low Carbohydrate ◽  
Serum Inflammatory Markers

scholarly journals An Investigation into the Antiobesity Effects ofMorinda citrifoliaL. Leaf Extract in High Fat Diet Induced Obese Rats Using a1H NMR Metabolomics Approach

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Najla Gooda Sahib Jambocus ◽  
Nazamid Saari ◽  
Amin Ismail ◽  
Alfi Khatib ◽  
Mohamad Fawzi Mahomoodally ◽  
...  
Keyword(s):  
Metabolic Pathways ◽  
High Fat Diet ◽  
Plasma Lipids ◽  
Tca Cycle ◽  
Treated Group ◽  
Morinda Citrifolia ◽  
Sprague Dawley ◽  
High Fat ◽  
Contributing Factors ◽  
Positive Effects

The prevalence of obesity is increasing worldwide, with high fat diet (HFD) as one of the main contributing factors. Obesity increases the predisposition to other diseases such as diabetes through various metabolic pathways. Limited availability of antiobesity drugs and the popularity of complementary medicine have encouraged research in finding phytochemical strategies to this multifaceted disease. HFD induced obese Sprague-Dawley rats were treated with an extract ofMorinda citrifoliaL. leaves (MLE 60). After 9 weeks of treatment, positive effects were observed on adiposity, fecal fat content, plasma lipids, and insulin and leptin levels. The inducement of obesity and treatment with MLE 60 on metabolic alterations were then further elucidated using a1H NMR based metabolomics approach. Discriminating metabolites involved were products of various metabolic pathways, including glucose metabolism and TCA cycle (lactate, 2-oxoglutarate, citrate, succinate, pyruvate, and acetate), amino acid metabolism (alanine, 2-hydroxybutyrate), choline metabolism (betaine), creatinine metabolism (creatinine), and gut microbiome metabolism (hippurate, phenylacetylglycine, dimethylamine, and trigonelline). Treatment with MLE 60 resulted in significant improvement in the metabolic perturbations caused obesity as demonstrated by the proximity of the treated group to the normal group in the OPLS-DA score plot and the change in trajectory movement of the diseased group towards the healthy group upon treatment.

scholarly journals The Absence of Adiponectin Alters Niacin’s Effects on Adipose Tissue Inflammation in Mice

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2427
Author(s):  
Emily C. Graff ◽  
Han Fang ◽  
Desiree Wanders ◽  
Robert L. Judd
Keyword(s):  
Adipose Tissue ◽  
High Fat Diet ◽  
Inflammatory Markers ◽  
Adipose Tissue Inflammation ◽  
High Fat ◽  
Tissue Inflammation ◽  
Low Fat Diet ◽  
Expression Of Genes ◽  
Ccl2 Expression ◽  
Anti Inflammatory

Obesity is an immunometabolic disease associated with chronic inflammation and the dysregulation of pro- and anti-inflammatory cytokines. One hallmark of obesity is reduced concentrations of the anti-inflammatory adipokine, adiponectin. Pharmacologic doses of niacin produce multiple metabolic benefits, including attenuating high-fat diet (HFD)-induced adipose tissue inflammation and increasing adiponectin concentrations. To determine if adiponectin mediates the anti-inflammatory effects of niacin, male C57BL/6J (WT) and adiponectin null (Adipoq-/-) mice were maintained on a low-fat diet (LFD) or HFD for 6 weeks, before being administered either vehicle or niacin (360 mg/kg/day) for 5 weeks. HFD-fed mice had increased expression of genes associated with macrophage recruitment (Ccl2) and number (Cd68), and increased crown-like structure (CLS) number in adipose tissue. While niacin attenuated Ccl2 expression, there were no effects on Cd68 or CLS number. The absence of adiponectin did not hinder the ability of niacin to reduce Ccl2 expression. HFD feeding increased gene expression of inflammatory markers in the adipose tissue of WT and Adipoq-/- mice. While niacin tended to decrease the expression of inflammatory markers in WT mice, niacin increased their expression in HFD-fed Adipoq-/- mice. Therefore, our results indicate that the absence of adiponectin alters the effects of niacin on markers of adipose tissue inflammation in HFD-fed mice, suggesting that the effects of niacin on tissue cytokines may involve adiponectin.

Abstract 347: Water-soluble Components of Sesame Oil Reduces Inflammation and Atherosclerosis

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Chandrakala Aluganti Narasimhulu ◽  
Krithika Selvarajan ◽  
Kathryn Burge ◽  
Dmitry Litvinov ◽  
Bhaswati Sengupta ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Plasma Lipids ◽  
Cholesterol Metabolism ◽  
Plasma Cholesterol ◽  
Sesame Oil ◽  
Water Soluble ◽  
Gene Analysis ◽  
High Fat ◽  
Atherosclerotic Lesions ◽  
Anti Inflammatory

Background: Atherosclerosis, a major form of cardiovascular disease, has now been recognized as a chronic inflammatory disease. Non-pharmacological means of treating chronic diseases have gained attention recently. We previously reported that the sesame oil aqueous extract (SOAE) has anti-inflammatory properties both in vitro and in vivo. In this study, we have determined whether SOAE has anti-atherosclerotic properties, and mechanisms by which it might modulate atherosclerosis by identifying genes and inflammatory markers. Methods and results: Low-density lipoprotein receptor knockout (LDLR-/-) female mice were fed with either high fat diet or high fat diet supplemented with SOAE. Plasma lipids and atherosclerotic lesions were quantified after 3 months of feeding. Plasma samples were used for global cytokine array. RNA was extracted from the liver tissue and the aorta and used for gene analysis. The SOAE-supplemented high fat diet significantly reduced atherosclerotic lesions, plasma cholesterol, and LDL cholesterol levels in LDLR-/- mice. Plasma inflammatory cytokines were reduced, but not significantly, demonstrating an anti-inflammatory property of SOAE. Gene analysis showed that SOAE-supplemented high fat diet reduced the genes involved in inflammation, and induced genes involved in cholesterol metabolism and reverse cholesterol transport. Conclusion: In conclusion, our studies suggest that a SOAE-enriched diet could be an effective non-pharmacological treatment for atherosclerosis by controlling inflammation and regulating lipid metabolism.

scholarly journals Impact of weight loss and partial weight regain on immune cell and inflammatory markers in adipose tissue in male mice

2020 ◽  
Vol 129 (4) ◽  
pp. 909-919
Author(s):  
Alexander T. Sougiannis ◽  
Brandon N. VanderVeen ◽  
Taryn L. Cranford ◽  
Reilly T. Enos ◽  
Kandy T. Velazquez ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Immune Cells ◽  
High Fat Diet ◽  
Inflammatory Markers ◽  
Weight Regain ◽  
Immune Cell ◽  
High Fat ◽  
Inflammatory Status ◽  
Partial Weight

We examined the immune and inflammatory status of adipose tissue in mice after they underwent weight loss followed by partial weight regain. We show an increase in selected immune cells and inflammatory mediators, in high-fat diet-fed mice that had prior exposure to a high-fat diet. Although weight fluctuations appear to exacerbate immune cell abundance and inflammation in adipose tissue, severity is less than in mice that were exposed to sustained high-fat diet feedings.

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