Zero effect of multiple dosage of olive leaf supplements on urinary biomarkers of oxidative stress in healthy humans

Nutrition ◽  
2009 ◽  
Vol 25 (3) ◽  
pp. 270-280 ◽  
Author(s):  
Megan Kendall ◽  
Marijka Batterham ◽  
Hassan Obied ◽  
Paul D. Prenzler ◽  
Danielle Ryan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Urinary Biomarkers ◽  
Olive Leaf ◽  
Healthy Humans ◽  
Zero Effect ◽  
Biomarkers Of Oxidative Stress

Urinary biomarkers of oxidative stress in atrial fibrillation

2018 ◽  
Vol 08 ◽  
Author(s):  
Tong Liu ◽  
Ricko Wong ◽  
Man Yin Tsui ◽  
Gary Tse ◽  
Guangping Li Tianjin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Atrial Fibrillation ◽  
Urinary Biomarkers ◽  
Biomarkers Of Oxidative Stress

scholarly journals Determination of adjusted reference intervals of urinary biomarkers of oxidative stress in healthy adults using GAMLSS models

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0206176 ◽  
Author(s):  
Liliya Chamitava ◽  
Vanessa Garcia-Larsen ◽  
Lucia Cazzoletti ◽  
Paolo Degan ◽  
Andrea Pasini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reference Intervals ◽  
Healthy Adults ◽  
Urinary Biomarkers ◽  
Biomarkers Of Oxidative Stress

scholarly journals Antioxidant Effect of Standardized Extract of Propolis (EPP-AF®) in Healthy Volunteers: A “Before and After” Clinical Study

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Débora P. Diniz ◽  
Daniela Aparecida Lorencini ◽  
Andresa Aparecida Berretta ◽  
Monica A. C. T. Cintra ◽  
Erica N. Lia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Healthy Volunteers ◽  
Cell Damage ◽  
Open Label ◽  
Sod Activity ◽  
Antioxidant Power ◽  
Healthy Humans ◽  
Before And After ◽  
Healthy Participants ◽  
Biomarkers Of Oxidative Stress

Background. Propolis is rich in polyphenols, especially flavonoids and phenolic acids, and has significant antioxidant activity, shown mainly in “in vitro” studies. Objective. The aim of this study was to evaluate the antioxidant efficacy and safety of a standardized propolis extract in healthy volunteers. Design. A two-phase sequential, open-label, nonrandomized, before and after clinical trial. Methods. Healthy participants received two EPP-AF® doses (375 and 750 mg/d, P.O, tid) during 7 ± 2 days, starting with the lower doses. Immediately before starting EPP-AF® administration and at the end of each 7-day dosing schedule, blood and urine samples were collected for quantification of 8-OHDG (8-hydroxydeoxyguanosine) and 8-ISO (8-isoprostanes) in urine and GSH (reduced glutathione), GSSG (oxidized glutathione), SOD (superoxide dismutase), FRAP (Ferric Reducing Antioxidant Power), vitamin E, and MDA (malondialdehyde) in plasma. Results. In our study, we had 34 healthy participants (67.7% women, 30 ± 8 years old, 97% white). The 8-ISO, a biomarker of lipid peroxidation, decreased with both doses of EPP-AF® compared to baseline (8-ISO, 1.1 (0.9–1.3) versus 0.85 (0.75–0.95) and 0.89 (0.74–1.0), ng/mg creatinine, P < 0.05 , for 375 and 750 mg/d EPP-AF® doses versus baseline, mean and CI 95%, respectively). 8-OHDG, a biomarker of DNA oxidation, was also reduced compared to baseline with 750 mg/d doses (8-OHDG, 15.7 (13.2–18.1) versus 11.6 (10.2–13.0), baseline versus 750 mg/d, respectively, ng/mg creatinine, P < 0.05 ). Reduction of biomarkers of oxidative stress damage was accompanied by increased plasma SOD activity (68.8 (66.1–73.3) versus 78.2 (72.2–80.5) and 77.7 (74.1–82.6), %inhibition, P < 0.0001 , 375 and 750 mg/d versus baseline, median and interquartile range 25–75%, respectively) and by increased GSH for 375 mg/d EPP-AF® doses (1.23 (1.06–1.34) versus 1.33 (1.06–1.47), μmol/L, P < 0.05 ). Conclusion. EPP-AF® reduced biomarkers of oxidative stress cell damage in healthy humans, with increased antioxidant enzymatic capacity, especially of SOD. This trial is registered with the Brazilian Registry of Clinical Trials (ReBEC, RBR-9zmfs9).

scholarly journals Clinical relevance of guanine-derived urinary biomarkers of oxidative stress, determined by LC-MS/MS

Redox Biology ◽  
2019 ◽  
Vol 20 ◽  
pp. 556-565 ◽  
Author(s):  
Ying-Ming Shih ◽  
Marcus S. Cooke ◽  
Chih-Hong Pan ◽  
Mu-Rong Chao ◽  
Chiung-Wen Hu
Keyword(s):  
Oxidative Stress ◽  
Clinical Relevance ◽  
Urinary Biomarkers ◽  
Biomarkers Of Oxidative Stress

scholarly journals Urinary biomarkers of oxidative stress and breast cancer survival

2014 ◽  
Vol 25 (6) ◽  
pp. 701-707 ◽  
Author(s):  
Sarah Nechuta ◽  
Qiuyin Cai ◽  
Ying Zheng ◽  
Ginger L. Milne ◽  
Hui Cai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Oxidative Stress ◽  
Cancer Survival ◽  
Breast Cancer Survival ◽  
Urinary Biomarkers ◽  
Biomarkers Of Oxidative Stress
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