Effects of preoperative carbohydrate loading on glucose metabolism and gastric contents in patients undergoing moderate surgery: A randomized, controlled trial

Nutrition ◽  
2008 ◽  
Vol 24 (3) ◽  
pp. 212-216 ◽  
Author(s):  
Gokhan Yagci ◽  
Mehmet Fatih Can ◽  
Erkan Ozturk ◽  
Birgul Dag ◽  
Taner Ozgurtas ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Glucose Metabolism ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Carbohydrate Loading ◽  
Gastric Contents ◽  
Preoperative Carbohydrate Loading

scholarly journals Vitamin D Supplementation and the Effects on Glucose Metabolism During Pregnancy: A Randomized Controlled Trial

Diabetes Care ◽  
2014 ◽  
Vol 37 (7) ◽  
pp. 1837-1844 ◽  
Author(s):  
Constance Yap ◽  
N. Wah Cheung ◽  
Jenny E. Gunton ◽  
Neil Athayde ◽  
Craig F. Munns ◽  
...  
Keyword(s):  
Vitamin D ◽  
Randomized Controlled Trial ◽  
Glucose Metabolism ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Randomized Controlled

scholarly journals Sucralose decreases insulin sensitivity in healthy subjects: a randomized controlled trial

2018 ◽  
Vol 108 (3) ◽  
pp. 485-491 ◽  
Author(s):  
Alonso Romo-Romo ◽  
Carlos A Aguilar-Salinas ◽  
Griselda X Brito-Córdova ◽  
Rita A Gómez-Díaz ◽  
Paloma Almeda-Valdes
Keyword(s):  
Randomized Controlled Trial ◽  
Insulin Sensitivity ◽  
Glucose Metabolism ◽  
Healthy Subjects ◽  
Controlled Trial ◽  
Insulin Response ◽  
Control Group ◽  
Acute Insulin Response ◽  
Randomized Controlled ◽  
Insulin Response To Glucose

ABSTRACT Background Recently, the absence of metabolic effects from nonnutritive sweeteners has been questioned. Objective The aim of this study was to evaluate the effects of sucralose consumption on glucose metabolism variables. Design We performed a randomized controlled trial involving healthy subjects without comorbidities and with a low habitual consumption of nonnutritive sweeteners (n = 33/group). Methods The intervention consisted of sucralose consumption as 15% of Acceptable Daily Intake every day for 14 d using commercial sachets. The control group followed the same procedures without any intervention. The glucose metabolism variables (insulin sensitivity, acute insulin response to glucose, disposition index, and glucose effectiveness) were evaluated by using a 3-h modified intravenous-glucose-tolerance test before and after the intervention period. Results Individuals assigned to sucralose consumption showed a significant decrease in insulin sensitivity with a median (IQR) percentage change of −17.7% (−29.3% to −1.0%) in comparison to −2.8% (−30.7% to 40.6%) in the control group (P= 0.04). An increased acute insulin response to glucose from 577 mU · L-1· min (350–1040 mU · L-1· min) to 671 mU · L-1· min (376–1010 mU · L-1· min) (P = 0.04) was observed in the sucralose group for participants with adequate adherence. Conclusions Sucralose may have effects on glucose metabolism, and our study complements findings previously reported in other trials. Further studies are needed to confirm the decrease in insulin sensitivity and to explore the mechanisms for these metabolic alterations. This trial was registered at www.clinicaltrials.gov as NCT02589002.

scholarly journals Preoperative carbohydrate loading and intraoperative goal-directed fluid therapy for elderly patients undergoing open gastrointestinal surgery: a prospective randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xia Liu ◽  
Peng Zhang ◽  
Meng Xue Liu ◽  
Jun Li Ma ◽  
Xin Chuan Wei ◽  
...  
Keyword(s):  
Postoperative Complications ◽  
Elderly Patients ◽  
Fluid Therapy ◽  
Controlled Trial ◽  
Gastrointestinal Surgery ◽  
Randomized Controlled ◽  
Carbohydrate Loading ◽  
Prospective Randomized Controlled Trial ◽  
Preoperative Carbohydrate Loading ◽  
Goal Directed Fluid Therapy

Abstract Background The effect of a combination of a goal-directed fluid protocol and preoperative carbohydrate loading on postoperative complications in elderly patients still remains unknown. Therefore, we designed this trial to evaluate the relative impact of preoperative carbohydrate loading and intraoperative goal-directed fluid therapy versus conventional fluid therapy (CFT) on clinical outcomes in elderly patients following gastrointestinal surgery. Methods This prospective randomized controlled trial with 120 patients over 65 years undergoing gastrointestinal surgery were randomized into a CFT group (n = 60) with traditional methods of fasting and water-deprivation, and a GDFT group (n = 60) with carbohydrate (200 ml) loading 2 h before surgery. The CFT group underwent routine monitoring during surgery, however, the GDFT group was conducted by a Vigileo/FloTrac monitor with cardiac index (CI), stroke volume variation (SVV), and mean arterial pressure (MAP). For all patients, demographic data, intraoperative parameters and postoperative outcomes were recorded. Results Patients in the GDFT group received significantly less crystalloids fluid (1111 ± 442.9 ml vs 1411 ± 412.6 ml; p < 0.001) and produced significantly less urine output (200 ml [150–300] vs 400 ml [290–500]; p < 0.001) as compared to the CFT group. Moreover, GDFT was associated with a shorter average time to first flatus (56 ± 14.1 h vs 64 ± 22.3 h; p = 0.002) and oral intake (72 ± 16.9 h vs 85 ± 26.8 h; p = 0.011), as well as a reduction in the rate of postoperative complications (15 (25.0%) vs 29 (48.3%) patients; p = 0.013). However, postoperative hospitalization or hospitalization expenses were similar between groups (p > 0.05). Conclusions Focused on elderly patients undergoing open gastrointestinal surgery, we found perioperative fluid optimisation may be associated with improvement of bowel function and a lower incidence of postoperative complications. Trial registration ChiCTR, ChiCTR1800018227. Registered 6 September 2018 - Retrospectively registered.

Sign in / Sign up

Export Citation Format

Share Document