Dose-dependent cholesterol-lowering effect of a mayonnaise-type product with a main component of diacylglycerol-containing plant sterol esters

Nutrition ◽  
2006 ◽  
Vol 22 (2) ◽  
pp. 174-178 ◽  
Author(s):  
Shinichiro Saito ◽  
Masao Takeshita ◽  
Kazuichi Tomonobu ◽  
Naoto Kudo ◽  
Daisuke Shiiba ◽  
...  
Keyword(s):  
Plant Sterol ◽  
Sterol Esters ◽  
Cholesterol Lowering ◽  
Lowering Effect ◽  
Main Component ◽  
Dose Dependent ◽  
Cholesterol Lowering Effect

scholarly journals Soy Protein Enhances the Cholesterol-Lowering Effect of Plant Sterol Esters in Cholesterol-Fed Hamsters

2004 ◽  
Vol 134 (1) ◽  
pp. 143-148 ◽  
Author(s):  
Yuguang Lin ◽  
Gert W. Meijer ◽  
Mario A. Vermeer ◽  
Elke A. Trautwein
Keyword(s):  
Soy Protein ◽  
Plant Sterol ◽  
Sterol Esters ◽  
Cholesterol Lowering ◽  
Lowering Effect ◽  
Cholesterol Lowering Effect

scholarly journals Triterpenic Acids Present in Hawthorn Lower Plasma Cholesterol by Inhibiting Intestinal ACAT Activity in Hamsters

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Yuguang Lin ◽  
Mario A. Vermeer ◽  
Elke A. Trautwein
Keyword(s):  
Plasma Lipids ◽  
Plasma Cholesterol ◽  
Control Diet ◽  
Lipid Lowering ◽  
Lower Plasma ◽  
Sterol Esters ◽  
Cholesterol Lowering ◽  
Acat Activity ◽  
Lowering Effect ◽  
Cholesterol Lowering Effect

Hawthorn (Crataegus pinnatifida) is an edible fruit used in traditional Chinese medicine to lower plasma lipids. This study explored lipid-lowering compounds and underlying mechanisms of action of hawthorn. Hawthorn powder extracts inhibited acylCoA:cholesterol acyltransferase (ACAT) activity in Caco-2 cells. The inhibitory activity was positively associated with triterpenic acid (i.e., oleanolic acid (OA) and ursolic acid (UA)) contents in the extracts. Cholesterol lowering effects of hawthorn and its potential additive effect in combination with plant sterol esters (PSE) were further studied in hamsters. Animals were fed a semi-synthetic diet containing 0.08% (w/w) cholesterol (control) or the same diet supplemented with (i) 0.37% hawthorn dichloromethane extract, (ii) 0.24% PSE, (iii) hawthorn dichloromethane extract (0.37%) plus PSE (0.24%) or (iv) OA/UA mixture (0.01%) for 4 weeks. Compared to the control diet, hawthorn, PSE, hawthorn plus PSE and OA/UA significantly lowered plasma non-HDL (VLDL + LDL) cholesterol concentrations by 8%, 9%, 21% and 6% and decreased hepatic cholesterol ester content by 9%, 23%, 46% and 22%, respectively. The cholesterol lowering effects of these ingredients were conversely associated with their capacities in increasing fecal neutral sterol excretion. In conclusion, OA and UA are responsible for the cholesterol lowering effect of hawthorn by inhibiting intestinal ACAT activity. In addition, hawthorn and particularly its bioactive compounds (OA and UA) enhanced the cholesterol lowering effect of plant sterols.

Study of cholesterol lowering effect of higher basidiomycetes

2007 ◽  
Vol 131 (2) ◽  
pp. S62
Author(s):  
Mark Shamtsyan ◽  
Alexey Popov ◽  
Andrey Panchenko ◽  
Nikolay Petrischev ◽  
Nina Denisova
Keyword(s):  
Cholesterol Lowering ◽  
Lowering Effect ◽  
Cholesterol Lowering Effect

N-Cyclohexyl Linoleamide: Metabolism and Cholesterol-Lowering Effect in Rats

Science ◽  
1966 ◽  
Vol 153 (3741) ◽  
pp. 1267-1269 ◽  
Author(s):  
H. Nakatani ◽  
H. Fukushima ◽  
A. Wakimura ◽  
M. Endo
Keyword(s):  
Cholesterol Lowering ◽  
Lowering Effect ◽  
Cholesterol Lowering Effect
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