Left ventricular mass and urinary metabolomics in young black and white adults: The African-PREDICT study

2020 ◽  
Vol 30 (11) ◽  
pp. 2051-2062
Author(s):  
Dalene De Beer ◽  
Catharina MC. Mels ◽  
Aletta E. Schutte ◽  
Roan Louw ◽  
Christian Delles ◽  
...  
Keyword(s):  
Left Ventricular Mass ◽  
Left Ventricular ◽  
Black And White ◽  
Ventricular Mass ◽  
White Adults ◽  
Predict Study

scholarly journals LEFT VENTRICULAR MASS AND URINARY METABOLOMICS IN YOUNG BLACK AND WHITE ADULTS: THE AFRICAN-PREDICT STUDY

2021 ◽  
Vol 39 (Supplement 1) ◽  
pp. e6
Author(s):  
Dalene De Beer ◽  
Catharina Mc Mels ◽  
Aletta E. Schutte ◽  
Roan Louw ◽  
Christian Delles ◽  
...  
Keyword(s):  
Left Ventricular Mass ◽  
Left Ventricular ◽  
Black And White ◽  
Ventricular Mass ◽  
White Adults ◽  
Predict Study

Comparison of Left Ventricular Mass and Geometry in Black and White Patients With Essential Hypertension

1993 ◽  
Vol 6 (10) ◽  
pp. 815-823 ◽  
Author(s):  
Michael J. Koren ◽  
George A. Mensah ◽  
James Blake ◽  
John H. Laragh ◽  
Richard B. Devereux
Keyword(s):  
Essential Hypertension ◽  
Left Ventricular Mass ◽  
Left Ventricular ◽  
Black And White ◽  
Ventricular Mass ◽  
White Patients

The renin-angiotensin-system and left ventricular mass in young adults: the African-PREDICT study

2020 ◽  
pp. 1-10
Author(s):  
Wessel L. du Toit ◽  
Aletta E. Schutte ◽  
Lebo F. Gafane-Matemane ◽  
Ruan Kruger ◽  
Catharina M. C. Mels
Keyword(s):  
Young Adults ◽  
Left Ventricular Mass ◽  
Renin Angiotensin System ◽  
Left Ventricular ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Ventricular Mass ◽  
Predict Study

scholarly journals Marinobufagenin and left ventricular mass in young adults: The African-PREDICT study

2018 ◽  
Vol 25 (15) ◽  
pp. 1587-1595 ◽  
Author(s):  
Michél Strauss ◽  
Wayne Smith ◽  
Ruan Kruger ◽  
Wen Wei ◽  
Olga V Fedorova ◽  
...  
Keyword(s):  
Young Adults ◽  
Stroke Volume ◽  
Left Ventricular Mass ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Left Ventricular ◽  
Target Organ ◽  
End Diastolic Volume ◽  
Ventricular Mass ◽  
Predict Study

Background The endogenous steroidal inhibitor of sodium–potassium-dependent adenosine triphosphate and natriuretic hormone, marinobufagenin, plays a physiological role in ionic homeostasis. Animal models suggest that elevated marinobufagenin adversely associates with cardiac and renal, structural and functional alterations. It remains uncertain whether marinobufagenin relates to the early stages of target organ damage development, especially in young adults without cardiovascular disease. We therefore explored whether elevated 24-hour urinary marinobufagenin excretion was related to indices of subclinical target organ damage in young healthy adults. Design This cross-sectional study included 711 participants from the African-PREDICT study (black 51%, men 42%, 24.8 ± 3.02 years). Methods We assessed cardiac geometry and function by two-dimensional echocardiography and pulse wave Doppler imaging. 24-Hour urinary marinobufagenin and sodium excretion were measured, and the estimated glomerular filtration rate determined. Results Across marinobufagenin excretion quartiles, left ventricular mass ( P < 0.001), end diastolic volume ( P < 0.001), stroke volume ( P = 0.004) and sodium excretion ( P < 0.001) were higher within the fourth compared with the first quartile. Partial regression analyses indicated that left ventricular mass ( r = 0.08, P = 0.043), end diastolic volume ( r = 0.10, P = 0.010) and stroke volume ( r = 0.09, P = 0.022) were positively related to marinobufagenin excretion. In multivariate-adjusted regression analysis, left ventricular mass associated positively with marinobufagenin excretion only in the highest marinobufagenin excretion quartile (adjusted R2 = 0.20; β = 0.15; P = 0.043). This relationship between left ventricular mass and marinobufagenin excretion was evident in women (adjusted R2 = 0.06; β = 0.127; P = 0.015) but not in men (adjusted R2 = 0.06; β = 0.007; P = 0.92). Conclusions Left ventricular mass positively and independently associates with marinobufagenin excretion in young healthy adults with excessively high marinobufagenin excretion. Women may be more sensitive to the effects of marinobufagenin on early structural cardiac changes.

Relationship of Cardiovascular Risk Factors to Echocardiographic Left Ventricular Mass in Healthy Young Black and White Adult Men and Women

Circulation ◽  
1995 ◽  
Vol 92 (3) ◽  
pp. 380-387 ◽  
Author(s):  
Julius M. Gardin ◽  
Lynne E. Wagenknecht ◽  
Hoda Anton-Culver ◽  
John Flack ◽  
Samuel Gidding ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Left Ventricular Mass ◽  
Left Ventricular ◽  
Men And Women ◽  
Black And White ◽  
Adult Men ◽  
Ventricular Mass ◽  
Relationship Of

scholarly journals The Cardiotonic Steroid Marinobufagenin Is a Predictor of Increased Left Ventricular Mass in Obesity: The African-PREDICT Study

Nutrients ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 3185
Author(s):  
Michél Strauss-Kruger ◽  
Ruan Kruger ◽  
Wayne Smith ◽  
Lebo F. Gafane-Matemane ◽  
Gontse Mokwatsi ◽  
...  
Keyword(s):  
Left Ventricular Mass ◽  
Cardiac Remodeling ◽  
Cardiac Fibrosis ◽  
Salt Intake ◽  
Left Ventricular ◽  
Percentage Change ◽  
Atpase Inhibitor ◽  
Obese Adults ◽  
Ventricular Mass ◽  
Predict Study

The endogenous Na+/K+-ATPase inhibitor, marinobufagenin (MBG), strongly associates with salt intake and a greater left ventricular mass index (LVMi) in humans and was shown to promote cardiac fibrosis and hypertrophy in animals. The adverse effects of MBG on cardiac remodeling may be exacerbated with obesity, due to an increased sensitivity of Na+/K+-ATPase to MBG. This study determined whether MBG is related to the change in LVMi over time in adults with a body mass index (BMI) ≥30 kg/m2 (obese) and <30 kg/m2 (non-obese). The study followed 275 healthy participants (aged 20–30 years) from the African-Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT) study over 4.5 years. At baseline, we measured 24 h urine MBG excretion. MBG levels were positively associated with salt intake. LVMi was determined by two-dimensional echocardiography at baseline and after >4.5 years. With multivariate adjusted analyses in obese adults (N = 56), we found a positive association of follow-up LVMi (Adjusted (Adj.) R2 = 0.35; Std. β = 0.311; p = 0.007) and percentage change in LVMi (Adj. R2 = 0.40; Std. β = 0.336; p = 0.003) with baseline MBG excretion. No association of LVMi (Adj. R2 = 0.37; p = 0.85) or percentage change in LVMi (Adj. R2 = 0.19; p = 0.68) with MBG excretion was evident in normal weight adults (N = 123). These findings suggest that obese adults may be more sensitive to the adverse cardiac effects of MBG and provide new insight into the potential role of dietary salt, by way of MBG, in the pathogenesis of cardiac remodeling in obese individuals.

Sign in / Sign up

Export Citation Format

Share Document