Dietary saturated fat intake and risk of stroke: Systematic review and dose–response meta-analysis of prospective cohort studies

2020 ◽  
Vol 30 (2) ◽  
pp. 179-189 ◽  
Author(s):  
Zhou-Qing Kang ◽  
Ying Yang ◽  
Bo Xiao
Keyword(s):  
Systematic Review ◽  
Cohort Studies ◽  
Dose Response ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Saturated Fat ◽  
Fat Intake ◽  
Prospective Cohort Studies ◽  
Saturated Fat Intake

Dietary Fat Intake and Risk of Alzheimer’s Disease and Dementia: A Meta-Analysis of Cohort Studies

2018 ◽  
Vol 15 (9) ◽  
pp. 869-876 ◽  
Author(s):  
Yue Ruan ◽  
Jun Tang ◽  
Xiaofei Guo ◽  
Kelei Li ◽  
Duo Li
Keyword(s):  
Cohort Studies ◽  
Dietary Fat ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Saturated Fat ◽  
Fat Intake ◽  
Prospective Cohort Studies ◽  
Dietary Fat Intake ◽  
Dementia Risk ◽  
Saturated Fat Intake

Background: Epidemiological studies showed that dietary fat intake is associated with Alzheimer’s disease (AD) and dementia risk, however, the association remain inconsistent. This metaanalysis aimed to systematically examine the association of dietary fat intake with AD and dementia risk. Methods: We have systematically searched PubMed, Embase and the Cochrane Library up to May 1st 2017. Prospective cohort studies were included if they reported on the association of dietary fat intake with AD and dementia risk. Multivariate-adjusted relative risks (RRs) for the highest versus lowest category were pooled by using a random-effects model. Results: A total of 8630 participants and 633 cases from four independent prospective cohort studies were included in the present meta-analysis. A higher dietary saturated fat intake was significantly associated with an increased risk of 39% and 105% for AD (RR: 1.39; 95% CI: 1.00, 1.94) and dementia (RR: 2.05; 95% CI: 1.06, 3.98), respectively. Dose-response analysis indicated a 4 g/day increment of saturated fat intake was related to 15% higher risk of AD (RR: 1.15; 95% CI: 1.01, 1.31). However, there was no significant association found between dietary intake of total, monounsaturated, polyunsaturated fat and AD or dementia risk. Conclusions: This meta-analysis provides significant evidence of positive association between higher saturated fat intake and AD and dementia risk.

scholarly journals The Effect of Saturated Fat Intake With Risk of Stroke and Coronary Heart Disease: A Systematic Review of Prospective Cohort Studies

2018 ◽  
Vol 10 (8) ◽  
pp. 28
Author(s):  
Hilal Al Shamsi ◽  
Abdullah Almutairi
Keyword(s):  
Systematic Review ◽  
Coronary Heart Disease ◽  
Prospective Cohort ◽  
Saturated Fat ◽  
Epidemiologic Studies ◽  
Fat Intake ◽  
Prospective Cohort Studies ◽  
Chd Risk ◽  
Increased Risk ◽  
Saturated Fat Intake

BACKGROUND: A decline in saturated fat intake has generally been thought to improve cardiovascular health.OBJECTIVE: The objective of this review is to summarize the evidence presented in recent prospective epidemiologic studies related to the association of saturated fat intake and risk of stroke and coronary heart disease (CHD).DESIGN: Sixteen prospective cohort studies identified by searches of the Medline and ProQuest databases are included in this review. The association of saturated fat intake with stroke and CHD risk is explored using the relative risk (RR), Hazard ratio (HR), and 95% confidence interval (CI) methods.RESULTS: Over follow-up periods of 8 to 30 years, 22,773 of 668,082 participants of these 16 studies developed stroke or CHD. Saturated fat intake was associated with an increased risk of CHD (HR = 2.36, 95% CI 1.10–5.09) but not with stroke. Gender and age had no impact on the stroke rate, whereas the female gender was a risk factor for CHD (HR = 3.07, 95% CI 1.54–6.11). In addition, a subgroup analysis showed a positive association between smoking history and increasing risk of stroke and CHD.CONCLUSION: This systematic review of prospective-cohort epidemiologic studies found that there is a weak to strong association between saturated fat intake and increased CHD risk but not significant evidence for concluding that saturated fat intake is associated with an increased risk of stroke. In addition, more research is needed to determine whether risk of stroke and/or CHD is potentially affected by specific nutrients used to replace saturated fat.

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