The different roles for the advanced glycation end products axis in heart failure and acute coronary syndrome settings

2019 ◽  
Vol 29 (10) ◽  
pp. 1050-1060 ◽  
Author(s):  
Beatriz Paradela-Dobarro ◽  
Rosa M. Agra ◽  
Leyre Álvarez ◽  
Alfonso Varela-Román ◽  
José M. García-Acuña ◽  
...  
Keyword(s):  
Heart Failure ◽  
Acute Coronary Syndrome ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Coronary Syndrome ◽  
Glycation End Products ◽  
End Products

scholarly journals Soluble Receptor for Advanced Glycation End Product: A Biomarker for Acute Coronary Syndrome

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Louise J. N. Jensen ◽  
Allan Flyvbjerg ◽  
Mette Bjerre
Keyword(s):  
Acute Coronary Syndrome ◽  
Advanced Glycation End Products ◽  
Acute Ischemia ◽  
Soluble Receptor ◽  
Advanced Glycation ◽  
Coronary Syndrome ◽  
Potential Biomarker ◽  
Glycation End Products ◽  
End Products ◽  
Artery Disease

The receptor of advanced glycation end products (RAGE) and its ligands are linked to the pathogenesis of coronary artery disease (CAD), and circulating soluble receptor of advanced glycation end products (sRAGE), reflecting the RAGE activity, is suggested as a potential biomarker. Elevated sRAGE levels are reported in relation to acute ischemia and this review focuses on the role of sRAGE as a biomarker for the acute coronary syndrome (ACS). The current studies demonstrated that sRAGE levels are elevated in relation to ACS, however during a very narrow time period, indicating that the time of sampling needs attention. Interestingly, activation of RAGE may influence the pathogenesis and reflection in sRAGE levels in acute and stable CAD differently.

Advanced glycation end-products as long-term predictors of death and reinfarction after an acute coronary syndrome

2015 ◽  
Vol 9 (3) ◽  
pp. 209-216 ◽  
Author(s):  
Sergio Raposeiras-Roubín ◽  
Bruno K Rodino-Janeiro ◽  
Beatriz Paradela-Dobarro ◽  
Haidara Almansour ◽  
Lilian Grigorian-Shamagian ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Coronary Syndrome ◽  
Glycation End Products ◽  
End Products

scholarly journals Fluorescent Advanced Glycation End Products and Their Soluble Receptor: The Birth of New Plasmatic Biomarkers for Risk Stratification of Acute Coronary Syndrome

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e74302 ◽  
Author(s):  
Sergio Raposeiras-Roubín ◽  
Bruno K. Rodiño-Janeiro ◽  
Beatriz Paradela-Dobarro ◽  
Lilian Grigorian-Shamagian ◽  
José M. García-Acuña ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Risk Stratification ◽  
Advanced Glycation End Products ◽  
Soluble Receptor ◽  
Advanced Glycation ◽  
Coronary Syndrome ◽  
Glycation End Products ◽  
End Products

scholarly journals Association study of polymorphisms in the receptor for advanced glycation end-products (RAGE) gene with susceptibility and prognosis of heart failure

Gene ◽  
2012 ◽  
Vol 510 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Carolina Rodrigues Cohen ◽  
Vanessa Backes Nascimento Diel ◽  
Vanessa Laubert La Porta ◽  
Luís Eduardo Rohde ◽  
Andréia Biolo ◽  
...  
Keyword(s):  
Heart Failure ◽  
Association Study ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

scholarly journals Chronic exercise training prevents coronary artery stiffening in aortic-banded miniswine: role of perivascular adipose-derived advanced glycation end products

2019 ◽  
Vol 127 (3) ◽  
pp. 816-827 ◽  
Author(s):  
An Ouyang ◽  
T. Dylan Olver ◽  
Craig A. Emter ◽  
Bradley S. Fleenor
Keyword(s):  
Heart Failure ◽  
Coronary Artery ◽  
Exercise Training ◽  
Arterial Stiffness ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Interval Exercise ◽  
Glycation End Products ◽  
End Products ◽  
Artery Stiffness

Heart failure (HF) is associated with increased large conduit artery stiffness and afterload resulting in stiffening of the coronary arteries. Perivascular adipose tissue (PVAT) and advanced glycation end products (AGE) both promote arterial stiffness, yet the mechanisms by which coronary PVAT promotes arterial stiffness and the efficacy of exercise to prevent coronary stiffness are unknown. We hypothesized that both chronic continuous and interval exercise training would prevent coronary PVAT-mediated AGE secretion and arterial stiffness. Yucatan miniature swine were divided into four groups: control-sedentary (CON), aortic banded sedentary-heart failure (HF), aortic banded HF-continuous exercise trained (HF+CONT), and aortic banded HF-interval exercise trained (HF+IT). The left circumflex and right coronary arteries underwent ex vivo mechanical testing, and arterial AGE, elastin, and collagen were assessed. Coronary elastin elastic modulus (EEM) and elastin protein were lower and AGE was increased with HF compared with CON, which was prevented by both HF+CONT and HF+IT. Mouse aortic segments treated with swine coronary PVAT conditioned medium had lower EEM and elastin content and greater AGE secretion and arterial AGE accumulation in HF compared with CON, which was prevented by both HF+CONT and HF+IT. Aminoguanidine (AMG), an AGE inhibitor, prevented the reduction in EEM, arterial elastin content, and AGE accumulation in mouse aortic segments treated with PVAT conditioned medium in the HF group. Our data demonstrate efficacy for chronic continuous and interval exercise to prevent coronary artery stiffness via inhibition of PVAT-derived AGE secretion in a preclinical miniswine model of pressure overload-induced HF. NEW & NOTEWORTHY Our findings show that chronic continuous and interval exercise training regimens prevent coronary artery stiffness associated with inhibition of perivascular adipose tissue-derived advanced glycation end products in a translational pressure overload-induced heart failure model potentially providing an effective therapeutic option for heart failure patients.

Relation of Soluble Receptor for Advanced Glycation End Products to Predict Mortality in Patients With Chronic Heart Failure Independently of Seattle Heart Failure Score

2011 ◽  
Vol 107 (6) ◽  
pp. 938-944 ◽  
Author(s):  
Sergio Raposeiras-Roubín ◽  
Bruno K. Rodiño-Janeiro ◽  
Lilian Grigorian-Shamagian ◽  
María Moure-González ◽  
Ana Seoane-Blanco ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Advanced Glycation End Products ◽  
Soluble Receptor ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products
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