Serum dietary fatty acids and coronary heart disease risk – A nested case-control-study within the CARLA cohort

2019 ◽  
Vol 29 (2) ◽  
pp. 152-158 ◽  
Author(s):  
D. Medenwald ◽  
A. Kluttig ◽  
M.E. Lacruz ◽  
J. Schumann
Keyword(s):  
Fatty Acids ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Case Control Study ◽  
Disease Risk ◽  
Case Control ◽  
Dietary Fatty Acids ◽  
Nested Case Control ◽  
Heart Disease Risk ◽  
Control Study

scholarly journals Human AGT -p.Met268Thr and coronary heart disease risk: a case-control study and meta-analysis

2018 ◽  
Vol 20 (1) ◽  
pp. 17-24
Author(s):  
Hanieh Mohammadi ◽  
Narges Razavi ◽  
Ali Abbasi ◽  
Faezeh Babaei ◽  
Ensiyeh Seyedrezazadeh ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Heart Disease Risk ◽  
Case Control Study ◽  
Disease Risk ◽  
Meta Analysis ◽  
Case Control ◽  
Heart Disease Risk ◽  
Control Study

Lipoprotein (a) and coronary heart disease risk: a nested case-control study of the Helsinki Heart Study participants

1991 ◽  
Vol 89 (1) ◽  
pp. 59-67 ◽  
Author(s):  
Matti Jauhiainen ◽  
Pekka Koskinen ◽  
Christian Ehnholm ◽  
M.Heikki Frick ◽  
Matti Mänttäri ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Case Control Study ◽  
Disease Risk ◽  
Case Control ◽  
Helsinki Heart Study ◽  
Heart Study ◽  
Study Participants ◽  
Nested Case Control ◽  
Heart Disease Risk ◽  
Control Study

Insight into the role of CYBA A640G and C242T gene variants and coronary heart disease risk. A case-control study

2008 ◽  
Vol 42 (1) ◽  
pp. 82-92 ◽  
Author(s):  
A. Macías-Reyes ◽  
F. Rodríguez-Esparragón ◽  
A. Caballero-Hidalgo ◽  
Y. Hernández-Trujillo ◽  
A. Medina ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Case Control Study ◽  
Disease Risk ◽  
Case Control ◽  
Gene Variants ◽  
Heart Disease Risk ◽  
Insight Into ◽  
Control Study

scholarly journals Leptin and Coronary Heart Disease Risk: Prospective Case Control Study of British Women*

Obesity ◽  
2007 ◽  
Vol 15 (7) ◽  
pp. 1694-1701 ◽  
Author(s):  
Debbie A. Lawlor ◽  
George Davey Smith ◽  
Anne Kelly ◽  
Naveed Sattar ◽  
Shah Ebrahim
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Heart Disease Risk ◽  
Case Control Study ◽  
Disease Risk ◽  
Case Control ◽  
Heart Disease Risk ◽  
Control Study ◽  
Prospective Case Control Study

scholarly journals Prediction of coronary heart disease incidence in a general male population by circulating non-coding small RNA sRNY1-5p in a nested case–control study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Vera L. Costa ◽  
Jean-Bernard Ruidavets ◽  
Vanina Bongard ◽  
Bertrand Perret ◽  
Emanuela Repetto ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Small Rna ◽  
Case Control Study ◽  
Disease Incidence ◽  
Case Control ◽  
Male Population ◽  
General Male Population ◽  
Nested Case Control ◽  
Control Study

AbstractDuring the development of atherosclerotic lesion, s-RNYs (small RNAs of about 24/34 nucleotides) are derived by the processing of long Ro-associated non-coding RNAs (RNYs) in macrophages. The levels of serum s-RNYs have been found significantly upregulated in patients with coronary heart disease (CHD) compared to age-matched CHD-free individuals. The present study aimed to examine the predictive value of serum s-RNYs for CHD events in the general male population. Within the frame of nested-case–control study, the GENES study, we measured the absolute expression of a RNY-derived small RNA, the s-RNY1-5p, in the serum of individuals (without CHD at baseline) who encountered a CHD event within 12 years of follow-up (n = 30) (Cases) and compared them to individuals who remained event-free (Controls) (n = 30). The expression of s-RNY1-5p in serum was significantly upregulated in Cases compared to Controls (p = 0.027). The proportion of CHD event-free was significantly higher among individuals with serum s-RNY1-5p below the median value (631 molecules/mL). In a multivariable model adjusted for age, smoking, hypertension, diabetes and dyslipidemia, the risk of CHD events increased more than fourfold in individuals with serum s-RNY1-5p above the median value (HR, 4.36; 95% CI 1.22–15.60). A positive association with CHD events was also observed when considering s-RNY1-5p as a continuous variable (p = 0.022). Based on our results, we conclude that serum s-RNY1-5p is an independent predictor of CHD events in a general male population and might be a relevant biomarker for early detection of cardiovascular diseases.

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