High irisin levels in overweight/obese children and its positive correlation with metabolic profile, blood pressure, and endothelial progenitor cells

2018 ◽  
Vol 28 (7) ◽  
pp. 756-764 ◽  
Author(s):  
F. De Meneck ◽  
L. Victorino de Souza ◽  
V. Oliveira ◽  
M.C. do Franco
Keyword(s):  
Blood Pressure ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Metabolic Profile ◽  
Obese Children ◽  
Endothelial Progenitor ◽  
Positive Correlation

scholarly journals Systemic microvascular rarefaction is correlated with dysfunction of late endothelial progenitor cells in mild hypertension: a substudy of EXCAVATION-CHN1

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Jianwen Liang ◽  
Yan Li ◽  
Long Chen ◽  
Wenhao Xia ◽  
Guifu Wu ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Early Detection ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Capillary Density ◽  
Tube Formation ◽  
Endothelial Progenitor ◽  
Hypertensive Patients ◽  
Normotensive Subjects ◽  
Microvascular Rarefaction

Abstract Background Hypertension often presents with microvascular rarefaction (MVR), which is closely associated with impaired angiogenesis. Early detection of MVR is essential for systemic assessment in patient with hypertension. We aimed to determine the systemic MVR through both optical coherence tomography angiography (OCTA) and intravital capillaroscopy, and to investigate their respective efficacies and related mechanisms associated with late endothelial progenitor cells (LEPCs) dysfunction. Methods Seventy-one hypertensive and sixty-nine age-match normotensive subjects were included in this study. All subjects received intravital capillaroscopy for skin capillary density (SCD) and OCTA for retinal capillary density (RCD) and non-perfused areas (R-NPA). Subsequently, correlation of LEPCs activities and microvascular rarefaction were examined. Results Compared with normotensive subjects, hypertensive patients had significantly lower RCD [(52.9 ± 2.9)% vs. (57.8 ± 1.6)%, P < 0.01] and higher R-NPA [(0.12 ± 0.07) mm2 vs. (0.053 ± 0.020) mm2, P < 0.01]. SCD correlated positively with RCD but negatively with R-NPA [(RCD: OR = 0.40, 95% CI 0.25–0.67, P < 0.01); (R-NPA: OR = 0.39, 95% CI − 0.0029 to 0.0011, P < 0.01)]. The discriminative powers of RCD performed best (AUC 0.79 versus SCD AUC 0.59, P < 0.001) followed by R-NPA (AUC 0.73 versus SCD AUC 0.59, P < 0.001) for systolic blood pressure. Similar pattern is also found for diastolic blood pressure (RCD AUC 0.80 versus SCD AUC 0.54, P < 0.001; R-NPA AUC 0.77 versus SCD AUC 0.54, P < 0.001). Furthermore, LEPCs tube formation was impaired in hypertensive patients (36.8 ± 2.3 vs. 28 ± 3.7, P < 0.01). After multivariate adjustments, positive correlation existed between RCD or R-NPA with LEPCs tube formation (RCD: β = 0.64, 95% CI 0.34–0.91, P < 0.01; R-NPA: β = − 24.67, 95% CI − 43.14 to − 4.63, P < 0.05) but not with SCD (β = 0.082, 95% CI 0.01–0.18, P = 0.085). Conclusion Compared to intravital capillaroscopy, OCTA is a more precise technique for early detection of hypertensive microvascular rarefaction, which is associated with the fall in LEPC-mediated angiogenesis. Both of OCTA and LEPCs function can help identify hypertension-related capillary abnormality. Trail Registration The trial is a substudy of EXCAVATION-CHN1, registered at clinicaltrials.gov as NCT02817204 (June 26, 2016).

scholarly journals External Counterpulsation Attenuates Hypertensive Vascular Injury Through Enhancing the Function of Endothelial Progenitor Cells

2021 ◽  
Vol 11 ◽  
Author(s):  
Jianwen Liang ◽  
Jian Shi ◽  
Wenbin Wei ◽  
Guifu Wu
Keyword(s):  
Blood Pressure ◽  
Multivariate Analysis ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Vascular Injury ◽  
Control Group ◽  
Endothelial Progenitor ◽  
Repair Capacity ◽  
Noninvasive Treatment ◽  
External Counterpulsation

BackgroundVascular injury is a landmark of hypertension and enhanced external counterpulsation (EECP) has been identified as a noninvasive treatment to restore the capacity of endothelial cells. However, the effect of EECP on blood pressure lowering in hypertension and the potential mechanism remain unknown.MethodsWe measured the ambulatory blood pressure (AMBP) and flow-mediated endothelial dilation (FMD) in the essential hypertensive patients who were randomly assigned to the EECP group (n = 20) or control group (n = 20). We also evaluated in vitro function of endothelial progenitor cells (EPCs). Furthermore, multivariate analysis was performed to determine the actual correlation between EPC function and FMD.ResultsCompared with the control, EECP group exhibited decreased systolic [(133.2 ± 4.9) mmHg vs. (139.3 ± 6.4) mmHg, P &lt; 0.05] and diastolic [(83.4 ± 4.5) mmHg vs. (89.5 ± 7.6) mmHg, P &lt; 0.05] blood pressure and increased FMD value [(8.87 ± 2.46%) vs. (7.51 ± 2.32%), P &lt; 0.01]. In addition, the migration [(47.3 ± 6.4)/hpf vs. (33.4 ± 5.1) hpf, P &lt; 0.05] and adhesion [(45.1 ± 5.5)/hpf vs. (28.4 ± 3.9) hpf, P &lt; 0.05] functions of EPCs in the EECP group were improved significantly, whereas no change was observed in the control. Both migration [odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.27–0.64, P &lt; 0.05] and adhesion (OR = 0.44, 95% CI = −0.0034 to 0.0012, P &lt; 0.05) of EPCs correlated with FMD. After multivariate analysis, the migration (β = 3.37, 95% CI = 1.67–5.33, P &lt; 0.05) and adhesion (β = 3.98, 95% CI = 1.12–6.43, P &lt; 0.05) functions still independently correlated to FMD.ConclusionThe present study demonstrates for the first time that EECP decreases both systolic and diastolic blood pressure and increases FMD value in hypertension. The fall in endogenous EPCs repair capacity might be an important mechanism of hypertensive vascular injury and could be restored by EECP.

scholarly journals Circulating endothelial progenitor cells in obese children and adolescents

2015 ◽  
Vol 91 (6) ◽  
pp. 560-566 ◽  
Author(s):  
António Pires ◽  
Paula Martins ◽  
Artur Paiva ◽  
Ana Margarida Pereira ◽  
Margarida Marques ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Obese Children ◽  
Endothelial Progenitor ◽  
Circulating Endothelial Progenitor Cells

Sympathetic predominance is associated with impaired endothelial progenitor cells and tunneling nanotubes in controlled-hypertensive patients

2014 ◽  
Vol 307 (2) ◽  
pp. H207-H215 ◽  
Author(s):  
Elena M. V. de Cavanagh ◽  
Sergio A. González ◽  
Felipe Inserra ◽  
Pedro Forcada ◽  
Carlos Castellaro ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Stress Test ◽  
Indirect Evidence ◽  
Tunneling Nanotubes ◽  
Endothelial Progenitor ◽  
Hypertensive Patients ◽  
Endothelial Repair ◽  
Normotensive Subjects

Early endothelial progenitor cells (early EPC) and late EPC are involved in endothelial repair and can rescue damaged endothelial cells by transferring organelles through tunneling nanotubes (TNT). In rodents, EPC mobilization from the bone marrow depends on sympathetic nervous system activity. Indirect evidence suggests a relation between autonomic derangements and human EPC mobilization. We aimed at testing whether hypertension-related autonomic imbalances are associated with EPC impairment. Thirty controlled-essential hypertensive patients [systolic blood pressure/diastolic blood pressure = 130(120–137)/85(61–88) mmHg; 81.8% male] and 20 healthy normotensive subjects [114(107–119)/75(64–79) mmHg; 80% male] were studied. Mononuclear cells were cultured on fibronectin- and collagen-coated dishes for early EPC and late EPC, respectively. Low (LF)- and high (HF)-frequency components of short-term heart rate variability were analyzed during a 5-min rest, an expiration/inspiration maneuver, and a Stroop color-word test. Modulations of cardiac sympathetic and parasympathetic activities were evaluated by LF/HF (%) and HF power (ms2), respectively. In controlled-hypertensive patients, the numbers of early EPC, early EPC that emitted TNT, late EPC, and late EPC that emitted TNT were 41, 77, 50, and 88% lower than in normotensive subjects ( P < 0.008), respectively. In controlled-hypertensive patients, late EPC number was positively associated with cardiac parasympathetic reserve during the expiration/inspiration maneuver (rho = 0.45, P = 0.031) and early EPC with brachial flow-mediated dilation (rho = 0.655; P = 0.049); also, late TNT number was inversely related to cardiac sympathetic response during the stress test (rho = −0.426, P = 0.045). EPC exposure to epinephrine or norepinephrine showed negative dose-response relationships on cell adhesion to fibronectin and collagen; both catecholamines stimulated early EPC growth, but epinephrine inhibited late EPC growth. In controlled-hypertensive patients, sympathetic overactivity/parasympathetic underactivity were negatively associated with EPC, suggesting that reducing sympathetic/increasing parasympathetic activation might favor endothelial repair.

scholarly journals Circulating endothelial progenitor cells in obese children and adolescents

2015 ◽  
Vol 91 (6) ◽  
pp. 560-566
Author(s):  
António Pires ◽  
Paula Martins ◽  
Artur Paiva ◽  
Ana Margarida Pereira ◽  
Margarida Marques ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Progenitor Cells ◽  
Endothelial Progenitor Cells ◽  
Obese Children ◽  
Endothelial Progenitor ◽  
Circulating Endothelial Progenitor Cells
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