scholarly journals High-sensitivity C-reactive protein, low-grade systemic inflammation and type 2 diabetes mellitus: A two-sample Mendelian randomization study

2018 ◽  
Vol 28 (8) ◽  
pp. 795-802 ◽  
Author(s):  
R. Noordam ◽  
C.H. Oudt ◽  
M.M. Bos ◽  
R.A.J. Smit ◽  
D. van Heemst
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Systemic Inflammation ◽  
Mendelian Randomization ◽  
High Sensitivity ◽  
Low Grade ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Serum C-Reactive Protein Concentration and Measures of Adiposity in Patients With Type 2 Diabetes Mellitus

2007 ◽  
Vol 7 (4) ◽  
pp. 322-327 ◽  
Author(s):  
Asija Začiragić ◽  
Jasminko Huskić ◽  
Almira Hadžović-Džuvo ◽  
Amina Valjevac ◽  
Nesina Avdagić ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Concentration ◽  
Control Group ◽  
Low Grade ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Serum Crp

We investigated serum concentration of C-reactive protein (CRP) and measures of adiposity in 30 patients with type 2 diabetes mellitus (15 male, 15 female) and 30 age and sex-matched apparently healthy subjects.CRP concentration was determined by laser nephelometry (BN II Analyzer) and CardioPhase high-sensitivity CRP (DADE BEHRING) was used as reagent which consists of polystyrene particles coated with mouse monoclonal antibodies to CRP.Results have shown that serum CRP concentration in patients with type 2 diabetes mellitus was statistically significantly higher compared to control group of healthy subjects (p<0,05). Body mass index (BMI) correlated significantly with serum concentration of CRP in patients with type 2 diabetes mellitus (r=0,614; p<0,001). Statistically significant positive correlation was also found between waist to hip ratio and serum CRP concentration in patients with type 2 diabetes mellitus (r=0,426; p<0,05).Elevated serum CRP concentration in patients with type 2 diabetes mellitus is probably caused by the presence of chronic low-grade inflammation in these patients. It is possible that determined increase of CRP concentration reflects activation of innate immune system components in patients with type 2 diabetes mellitus. Implications of established association between measures of adiposity and serum CRP level in type 2 diabetes mellitus remain unclear.

Sign in / Sign up

Export Citation Format

Share Document