scholarly journals Sympathetic neurotransmission during atherosclerosis development: An unrecognized target of dyslipidemia?

2017 ◽  
Vol 27 (1) ◽  
pp. e27
Author(s):  
S. Manzini ◽  
M. Busnelli ◽  
D.S. Horner ◽  
M. Chiara ◽  
G.S. Ganzetti ◽  
...  
Keyword(s):  
Sympathetic Neurotransmission ◽  
Atherosclerosis Development

scholarly journals Sympathetic neurotransmission during atherosclerosis development: An unrecognized target of dyslipidemia?

2015 ◽  
Vol 241 (1) ◽  
pp. e98
Author(s):  
G. Chiesa ◽  
S. Manzini ◽  
D.S. Horner ◽  
M. Chiara ◽  
G.S. Ganzetti ◽  
...  
Keyword(s):  
Sympathetic Neurotransmission ◽  
Atherosclerosis Development

Metalloproteinases, Sialidases and NADPH Oxidases as Key Enzymes involved in Atherosclerosis Development

2019 ◽  
Vol 10 (3) ◽  
Author(s):  
Anastasia V Poznyak ◽  
Dmitry A Kashirskikh ◽  
Victoria A Khotina ◽  
Andrey V Grechko ◽  
Alexander N Orekhov
Keyword(s):  
Nadph Oxidases ◽  
Key Enzymes ◽  
Atherosclerosis Development

Inhibition of Atherosclerosis Development in Cholesterol-Fed Human Apolipoprotein A-I–Transgenic Rabbits

Circulation ◽  
1996 ◽  
Vol 94 (4) ◽  
pp. 713-717 ◽  
Author(s):  
Nicolas Duverger ◽  
Howard Kruth ◽  
Florence Emmanuel ◽  
Jean-Michel Caillaud ◽  
Ce´line Viglietta ◽  
...  
Keyword(s):  
Human Apolipoprotein ◽  
Apolipoprotein A ◽  
Transgenic Rabbits ◽  
Atherosclerosis Development

scholarly journals AB0392 THE EFFECT OF HYDROXYCHLOROQUINE ON THE RISK FACTORS FOR ATHEROSCLEROSIS DEVELOPMENT

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1496.3-1496
Author(s):  
R. Wakiya ◽  
K. Ueeda ◽  
H. Shimada ◽  
S. Nakashima ◽  
M. Mahmoud Fahmy Mansour ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lupus Nephritis ◽  
Disease Activity ◽  
Lupus Erythematosus ◽  
Past History ◽  
Serum Adiponectin ◽  
Rank Test ◽  
Tnf Α ◽  
Signed Rank Test ◽  
Atherosclerosis Development

Background:Systemic lupus erythematosus(SLE) patients, especially patients with lupus nephritis have poor vascular endothelial function and increased cardiovascular(CV) mortality.Meanwhile, several studies showed hydroxychloroquine(HCQ) has effect on reduction in lipids and thrombosis(1), but the mechanism is unclear.Objectives:We examined effect of HCQ on adipocytokine expression in SLE patients.Methods:52 SLE patients with low disease activity started with HCQ were analyzed before and 3 months after HCQ treatment. 21 SLE patients has past history of lupus nephritis. Serum S100 proteins and adipocytokines were measured by ELISA, and serum inflammatory ctytokine levels were evaluated by Multiplex assay (TNF-α, IL-6, VEGF-A).Results:Serum adiponectin level was increased significantly 3 months after HCQ treatment compared with those at baseline (mean change 1.35, Figure 1). SLE patients who achieved LLDAS had a greater increase than those who did not. Additionally, the changes of serum adiponectin levels were associated with those of TNF-α, IL-6, VEGF-A and S100A9 protein, which plays an important role of SLE pathogenesis.Figure 1.Serum adiponectin levels at baseline were compared with levels after 3 months of HCQ treatment. Serum adiponectin levels significantly decreasing during HCQ treatment in SLE patients. For statistical analyses *p<0.0001,Pvalue: Wilcoxon signed-rank testConclusion:A HCQ could reduce the risk factors for atherosclerosis along with control of SLE disease activity.References:[1]Wallace DJ, et al. Cholesterol-lowering effect of hydroxychloroquine in patients with rheumatic disease: reversal of deleterious effects of steroids on lipids. Am J Med. 1990; 89: 322-6.Disclosure of Interests:None declared

scholarly journals Food restriction by intermittent fasting induces diabetes and obesity and aggravates spontaneous atherosclerosis development in hypercholesterolaemic mice

2013 ◽  
Vol 111 (6) ◽  
pp. 979-986 ◽  
Author(s):  
Gabriel G. Dorighello ◽  
Juliana C. Rovani ◽  
Christopher J. F. Luhman ◽  
Bruno A. Paim ◽  
Helena F. Raposo ◽  
...  
Keyword(s):  
Knockout Mice ◽  
Plasma Levels ◽  
Food Restriction ◽  
Ldl Receptor ◽  
Intermittent Fasting ◽  
Wild Type ◽  
Obesity And Diabetes ◽  
Ad Libitum ◽  
Atherosclerosis Development ◽  
Ldl Receptor Knockout Mice

Different regimens of food restriction have been associated with protection against obesity, diabetes and CVD. In the present study, we hypothesised that food restriction would bring benefits to atherosclerosis- and diabetes-prone hypercholesterolaemic LDL-receptor knockout mice. For this purpose, 2-month-old mice were submitted to an intermittent fasting (IF) regimen (fasting every other day) over a 3-month period, which resulted in an overall 20 % reduction in food intake. Contrary to our expectation, epididymal and carcass fat depots and adipocyte size were significantly enlarged by 15, 72 and 68 %, respectively, in the IF mice compared with the ad libitum-fed mice. Accordingly, plasma levels of leptin were 50 % higher in the IF mice than in the ad libitum-fed mice. In addition, the IF mice showed increased plasma levels of total cholesterol (37 %), VLDL-cholesterol (195 %) and LDL-cholesterol (50 %). As expected, in wild-type mice, the IF regimen decreased plasma cholesterol levels and epididymal fat mass. Glucose homeostasis was also disturbed by the IF regimen in LDL-receptor knockout mice. Elevated levels of glycaemia (40 %), insulinaemia (50 %), glucose intolerance and insulin resistance were observed in the IF mice. Systemic inflammatory markers, TNF-α and C-reactive protein, were significantly increased and spontaneous atherosclerosis development were markedly increased (3-fold) in the IF mice. In conclusion, the IF regimen induced obesity and diabetes and worsened the development of spontaneous atherosclerosis in LDL-receptor knockout mice. Although being efficient in a wild-type background, this type of food restriction is not beneficial in the context of genetic hypercholesterolaemia.

scholarly journals Daily Sitting for Long Periods Increases the Odds for Subclinical Atheroma Plaques

2021 ◽  
Vol 10 (6) ◽  
pp. 1229
Author(s):  
Jose Luis Perez-Lasierra ◽  
Martin Laclaustra ◽  
Pilar Guallar-Castillón ◽  
Jose Antonio Casasnovas ◽  
Jose Antonio Casajús ◽  
...  
Keyword(s):  
Physical Activity ◽  
Subclinical Atherosclerosis ◽  
Sitting Time ◽  
Health Study ◽  
Activity Levels ◽  
Cross Sectional ◽  
Trained Personnel ◽  
Atherosclerosis Development ◽  
Sectional Analysis ◽  
The Relationship

Sedentarism is a risk factor for cardiovascular disease (CVD), but currently it is not clear how a sedentary behavior such as long sitting time can affect atherosclerosis development. This study examined the relationship between sitting time and the prevalence of carotid and femoral subclinical atherosclerosis. A cross-sectional analysis based on a subsample of 2082 participants belonging to the Aragon Workers’ Health Study was carried out. Ultrasonography was used to assess the presence of plaques in carotid and femoral territories; the validated Spanish version of the questionnaire on the frequency of engaging in physical activity used in the Nurses’ Health Study and the Health Professionals’ was used to assess physical activity and sitting time; and demographic, anthropometric, and clinical data were obtained by trained personnel during the annual medical examination. Participants were categorized into <9 h/day and ≥9 h/day sitting time groups. After adjusting for several confounders, compared with participants that remain seated <9 h/day, those participants who remain seated ≥9 h/day had, respectively, OR = 1.25 (95%CI: 1.01, 1.55, p < 0.05) and OR = 1.38 (95%CI: 1.09, 1.74, p < 0.05) for carotid and any-territory plaque presence. Remaining seated ≥9 h/day is associated with higher odds for carotid and any-territory plaque presence independently of physical activity levels and other cardiovascular risk factors.

A comparison of histamine effects on the sympathetic neurotransmission of testicular capsule and rat vas deferens

2014 ◽  
Vol 387 (8) ◽  
pp. 719-731 ◽  
Author(s):  
Edilson Dantas da Silva Júnior ◽  
Juliano Quintella Dantas Rodrigues ◽  
Bruno Palmieri de Souza ◽  
Afonso Caricati-Neto ◽  
Aron Jurkiewicz ◽  
...  
Keyword(s):  
Vas Deferens ◽  
Rat Vas Deferens ◽  
Sympathetic Neurotransmission ◽  
Testicular Capsule

Role of myeloperoxidase-mediated modification of human blood lipoproteins in atherosclerosis development

2007 ◽  
Vol 144 (3) ◽  
pp. 428-431 ◽  
Author(s):  
O. M. Panasenko ◽  
T. V. Vakhrusheva ◽  
I. I. Vlasova ◽  
A. V. Chekanov ◽  
Yu. V. Baranov ◽  
...  
Keyword(s):  
Human Blood ◽  
Atherosclerosis Development

scholarly journals Annexin A5 prevents post-interventional accelerated atherosclerosis development in a dose-dependent fashion in mice

2012 ◽  
Vol 221 (2) ◽  
pp. 333-340 ◽  
Author(s):  
M.M. Ewing ◽  
J.C. Karper ◽  
M.L. Sampietro ◽  
M.R. de Vries ◽  
K. Pettersson ◽  
...  
Keyword(s):  
Annexin A5 ◽  
Accelerated Atherosclerosis ◽  
Dose Dependent Fashion ◽  
Atherosclerosis Development ◽  
Dose Dependent
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