scholarly journals Dietary fat intake modifies the influence of the FTO rs9939609 polymorphism on adiposity in adolescents: The HELENA cross-sectional study

2016 ◽  
Vol 26 (10) ◽  
pp. 937-943 ◽  
Author(s):  
I. Labayen ◽  
J.R. Ruiz ◽  
I. Huybrechts ◽  
F.B. Ortega ◽  
L. Arenaza ◽  
...  
2020 ◽  
Vol 61 (6) ◽  
pp. 933-944 ◽  
Author(s):  
Sandi M. Azab ◽  
Russell J. de Souza ◽  
Koon K. Teo ◽  
Sonia S. Anand ◽  
Natalie C. Williams ◽  
...  

Nutritional studies rely on various biological specimens for FA determination, yet it is unclear how levels of serum NEFAs correlate with other circulating lipid pools. Here, we used a high-throughput method (<4 min/sample) based on multisegment injection-nonaqueous capillary electrophoresis-mass spectrometry (MSI-NACE-MS) to investigate whether specific serum NEFAs have utility as biomarkers of dietary fat intake in women. We first identified circulating NEFAs correlated with long-term/habitual food intake among pregnant women with contrasting dietary patterns (n = 50). Acute changes in serum NEFA trajectories were also studied in nonpregnant women (n = 18) following high-dose (5 g/day) fish oil (FO) supplementation or isoenergetic sunflower oil placebo over 56 days. In the cross-sectional study, serum ω-3 FAs correlated with self-reported total ω-3 daily intake, notably EPA as its NEFA (r = 0.46; P = 0.001), whereas pentadecanoic acid was associated with full-fat dairy intake (r = 0.43; P = 0.002), outcomes consistent with results from total FA serum hydrolysates. In the intervention cohort, serum ω-3 NEFAs increased 2.5-fold from baseline within 28 days following FO supplementation, and this increase was most pronounced for EPA (P = 0.0004). Unlike for DHA, circulating EPA as its NEFA also strongly correlated to EPA concentrations measured from erythrocyte phospholipid hydrolysates (r = 0.66; P = 4.6 × 10−10) and was better suited to detect dietary nonadherence. We conclude that MSI-NACE-MS offers a rapid method to quantify serum NEFAs and objectively monitor dietary fat intake in women that is complementary to food-frequency questionnaires.


2013 ◽  
Vol 16 (12) ◽  
pp. 2146-2153 ◽  
Author(s):  
Bruna Maria Silveira ◽  
David Alejandro Gonzalez-Chica ◽  
Rossana Pacheco da Costa Proença

AbstractObjectiveThe present study investigated how trans-fat is reported on the packaging of foods sold in a Brazilian supermarket.DesignThe present descriptive, cross-sectional study analysed the ingredient list, nutrition facts label and claims of no trans-fat on the packaging.SettingA large supermarket in Florianópolis, Brazil.SubjectsAll food products available at the supermarket.ResultsOf the 2327 study products, more than half had components containing trans-fat in the ingredient list, especially hydrogenated vegetable fat and its alternative names. A small percentage of food products reported some trans-fat content on the nutrition facts label and roughly a quarter of the food products claimed to contain no trans-fat on the front of the packaging. There was very low agreement among the trans-fat content reported in the nutrition facts label, claims of no trans-fat made on the packaging and the ingredient list.ConclusionsThere was low agreement among the different ways of reporting trans-fat, suggesting that it is not possible to rely on the nutrition facts label or no trans-fat claims printed on the packaging of Brazilian food products. Hence, the Brazilian legislation on food labels needs to change to improve the reliability of food labels and to help control the trans-fat intake of the population.


2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Fajar Aprilianti ◽  
Shirley E.S. Kawengian ◽  
Alexander S. L. Bolang

Abstract: Fat consumption is now a growing thing in the notice due to changes lifestyle. Excessive fat will increase the risk of obesity and accounted for heart disease. Fat is the most dense source of energy, which produces 9 kcal / gram with the the total dietary fat consumption which is good for health should be 20-30% of the total energy needs. High sensitive C-reactive protein (hs CRP) is a very sensitive test for the detection of cardiovascular risk, coronary heart disease (CHD). The objective of this study was to examine the association between dietary fat intake and levels of hs CRP among the medical students of the Faculty of Medicine, University of Sam Ratulangi Manado. This study was an analytical cross-sectional design, conducted in November - December 2012 with 59 respondents. Using the Mann Whitney test, the result showed that there was no difference in dietary fat intake of obes and non-obes (p = 0.85 > 0.05  with z =  -0,19). Levels of hs-CRP serum obes and non-obes showed that there was difference (p = 0.00 < 0.05 with z= -3,55). Spearman rank test, the result showed that there was no significant association between dietary fat intake and levels of hs-CRP among the medical students of the Faculty of Medicine, University of Sam Ratulangi. Manado (p = 0,61 > 0,05 with r = 0,06). Keywords: Dietary fat intake, hs-CRP levels, CHD, Obesity. Abstrak: Konsumsi lemak saat ini merupakan hal yang semakin di perhatikan karena perubahan gaya hidup. Lemak yang berlebihan akan meningkatkan obesitas dan menyumbang resiko penyakit jantung. Lemak menghasilkan 9 kkal/gram dengan konsumsi yang dianjurkan sebanyak 20-30% dari total kebutuhan energi. High sensitive-C reactive protein (hs-CRP) merupakan uji yang sangat sensitive  untuk mendeteksi resiko kardiovaskular,penyakit jantung koroner (PJK). Tujuan dari penelitian ini ialah untuk mengetahui perbedaan antara asupan lemak dengan kadar hs CRP mahasiswa obes dengan tidak obes pada Fakultas Kedokteran Universitas Sam Ratulangi Manado. Desain penelitian ini bersifat analitik dengan pendekatan cross sectional. Penelitian ini dilakukan pada bulan November-Desember 2012 dengan jumlah sampel sebanyak 59 orang. Hasil penelitian perbedaan asupan lemak obes dan non obes  menggunakan uji Mann Whitney dengan nilai p=0,85 >0,05 menunjukan tidak adanya perbedaan asupan lemak mahasiswa obes dengan tidak obes. Nilai p=0,00 < 0,05 menunjukan ada perbedaan kadar hs-CRP mahasiswa obes dan tidak obes. Uji Spearman rank dengan nilai p = 0,61 > 0.05 dengan nilai r = 0,06 menunjukan ada hubungan positif yang lemah tetapi tidak bermakna antara asupan lemak dengan kadar hs-CRP pada mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi. Kata kunci: Asupan lemak, hs-CRP, PJK, Obesitas.


2021 ◽  
Author(s):  
Atieh Mirzababaei ◽  
Elnaz Daneshzad ◽  
Farideh Shiraseb ◽  
Sanaz Pourreza ◽  
Leila Setayesh ◽  
...  

Abstract Background: Previous studies have shown that the minor allele (C allele) for Cry 1 rs2287161, may be associated with increased risk of cardiovascular diseases (CVDs). Low resting metabolic rate (RMR) caused by the diet has been shown to have, potentially, unfavorable effects on obesity. This study sought to investigate the interactions between the Cry 1 Gene and fat intake on RMR in overweight and obese women.Methods: This comparative cross-sectional study was conducted on 377 Iranian women with overweight and obesity. A food frequency questionnaire (FFQ), with 147 items, was used to assess dietary intake. Individuals were categorized into two groups based on the rs2287161 genotype. Body composition, dietary intake, and RMR were assessed for all participants.Results: There was a significant difference between genotypes for FBS (P=0.04), fat free mass (FFM) (P=0.0009), RMR per FFM (P =0.05), RMR per body mass index (BMI) (P=0.02), and RMR deviation (P=0.01). Our findings also showed significant interactions between total fat and C allele carrier group on RMR per kg, RMR per body surface area (BSA), RMR per FFM, and RMR deviation (P for interaction <0.1), in addition to a significant interaction between CC+CG group genotype and PUFA intake on RMR per BMI (P for interaction =0.009) and RMR per kg (P for interaction=0.02) and RMR per BSA (P=0.07), compared to the GG group, after control for confounder factors.Conclusion: These results highlight that dietary compositions, gene variants, and their interaction, should be acutely considered in lower RMR.


2008 ◽  
Vol 33 (2) ◽  
pp. 239-245 ◽  
Author(s):  
Jennifer L. Kuk ◽  
Lance E. Davidson ◽  
Robert Hudson ◽  
Katherine Kilpatrick ◽  
Kinga Bacskai ◽  
...  

Whether dietary fat influences the interaction between liver fat, visceral adipose tissue (VAT), and metabolic risk is unclear. Thus, we sought to determine the independent associations between 1 and 10 d dietary fat intake, liver fat, and VAT on insulin sensitivity using a cross-sectional design. Liver fat score (LFS) was assessed by computed tomography and VAT by magnetic resonance imaging in 42 abdominally obese older men. Insulin sensitivity was measured by the hyperinsulinemic–euglycemic clamp technique. Diet composition was determined from self-recorded diet records for 1 and 10 d preceding the assessment of LFS. LFS was positively associated with the 10 d average fat and alcohol intake, but not with any 1 d average dietary variables. VAT (r = –0.36) and LFS (r = –0.32) were both negatively correlated with insulin sensitivity (p < 0.05). When LFS and VAT were entered in the same model, only VAT was an independent predictor of insulin sensitivity (p < 0.05). Control for the average 10 d alcohol consumption and fat intake improved the association between insulin sensitivity and LFS (from r = –0.32, p > 0.10 to r = –0.49, p < 0.05), but not VAT. In fact, after control for the 10 d dietary variables, both LFS and VAT were independent predictors of insulin sensitivity (p < 0.05). This was not true for any of the 1 d dietary intake variables. In conclusion, liver fat is associated with dietary fat intake and alcohol consumption over 10 d, but not 1 d. Furthermore, dietary habits may influence the relationship between liver fat and insulin sensitivity.


2019 ◽  
Vol 18 (4) ◽  
pp. 387-390
Author(s):  
Desmawati . ◽  
Delmi Sulastri ◽  
Yuniar Lestari ◽  
Ulya Uti Fasrin ◽  
Afriwardi .

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