Interaction between GPR120 p.R270H loss-of-function variant and dietary fat intake on incident type 2 diabetes risk in the D.E.S.I.R. study

2016 ◽  
Vol 26 (10) ◽  
pp. 931-936 ◽  
Author(s):  
A. Lamri ◽  
A. Bonnefond ◽  
D. Meyre ◽  
B. Balkau ◽  
R. Roussel ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Fat ◽  
Diabetes Risk ◽  
Fat Intake ◽  
Loss Of Function ◽  
Incident Type ◽  
Dietary Fat Intake ◽  
Incident Type 2 Diabetes

1734-P: High Dietary Fat Intake Exacerbates Insulin Resistance in a Type 2 Diabetes Genetic Mouse Model

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1734-P
Author(s):  
AUSTIN REILLY ◽  
SHIJUN YAN ◽  
ALEXA J. LONCHARICH ◽  
HONGXIA REN
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Mouse Model ◽  
Dietary Fat ◽  
Fat Intake ◽  
Dietary Fat Intake ◽  
Genetic Mouse Model

scholarly journals Food sources of fat may clarify the inconsistent role of dietary fat intake for incidence of type 2 diabetes

2015 ◽  
Vol 101 (5) ◽  
pp. 1065-1080 ◽  
Author(s):  
Ulrika Ericson ◽  
Sophie Hellstrand ◽  
Louise Brunkwall ◽  
Christina-Alexandra Schulz ◽  
Emily Sonestedt ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Dietary Fat ◽  
Food Sources ◽  
Fat Intake ◽  
Dietary Fat Intake

Abstract MP037: Plasma Organochlorine Concentration and Risk of Diabetes: the Nurses' Health Study

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Hongyu Wu ◽  
Kimberly A Bertrand ◽  
Anna L Choi ◽  
Frank B Hu ◽  
Francine Laden ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Polychlorinated Biphenyl ◽  
Plasma Concentrations ◽  
Diabetes Risk ◽  
Health Study ◽  
Blood Draw ◽  
Incident Type ◽  
Increased Risk ◽  
Incident Type 2 Diabetes

Background: Animal experiments have suggested that exposure to persistent organic pollutants (POPs) may lead to increased risk of type 2 diabetes. Although recent human studies supported this hypothesis, evidence from prospective investigations is sparse. Objective: To examine the associations of plasma POP concentrations with risk of incident type 2 diabetes in a prospective setting among US women. Methods: Study population was comprised of participants from two independent nested case-control studies in the Nurses’ Health Study, in which major polychlorinated biphenyl (PCB 118, 138, 153, and 180), p-p'- dichlorodiphenyldichloroethylene (DDE), dichlorodiphenyltrichloroethane (DDT), and hexachlorobenzene (HCB) were measured. A non-parametric approach was used to derive standardized scores for plasma concentrations of lipid-adjusted POPs within each study to minimize between-study variation of the POP measurements. Risk of incident type 2 diabetes during the follow-up period (1990-2008) across the tertiles of the scores was examined. Results: Of 1,120 participants, we identified 48 incident type 2 diabetes cases. After adjusting for covariates assessed at blood draw in 1990, including smoking status, body mass index, and total fish intake, plasma HCB concentration was positively associated with type 2 diabetes risk: odds ratio (OR) (95% confidence interval [CI]) was 2.77 (1.17, 6.55, P for trend =0.022) comparing the highest vs. lowest tertile. Other POPs were not significantly associated with diabetes: the ORs (95% CI) were 1.10 (0.51, 2.34, P for trend =0.81) for p-p'-DDE, 0.93 (0.44, 1.95, P for trend =0.86) for DDT, and 0.88 (0.39, 1.97, P for trend =0.76) for sum of the 4 major PCBs, comparing the extreme tertiles. Conclusion: The significant association of plasma HCB concentration with diabetes risk supports a role of POP exposure in the etiology of type 2 diabetes. More prospective data are warranted to confirm these findings.

scholarly journals Variability in estimated glomerular filtration rate and the incidence of type 2 diabetes: a nationwide population-based study

2020 ◽  
Vol 8 (1) ◽  
pp. e001187
Author(s):  
You-Bin Lee ◽  
Da Hye Kim ◽  
Eun Roh ◽  
So-Hyeon Hong ◽  
Jung A Kim ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Diabetes Risk ◽  
Incident Type ◽  
Incident Type 2 Diabetes

ObjectiveVariability in estimated glomerular filtration rate (eGFR) has been associated with adverse outcomes in patients with diabetes or chronic kidney disease (CKD). However, no previous study has explored the relationship between eGFR variability and type 2 diabetes incidence.Research design and methodsIn this nationwide, longitudinal, cohort study, we investigated the association between eGFR variability and type 2 diabetes risk using the Korean National Health Insurance Service datasets from 2002 to 2017. eGFR variability was calculated using the variability independent of the mean (eGFR-VIM), coefficient of variation (eGFR-CV), standard deviation (eGFR-SD) and average real variability (eGFR-ARV).ResultsWithin 7 673 905.58 person-years of follow-up (mean follow-up: 3.19 years; n=2 402 668), 11 981 cases of incident type 2 diabetes were reported. The HRs and 95% CIs for incident type 2 diabetes increased according to advance in quartiles of eGFR-VIM (HR (95% CI): Q2, 1.068 (1.009 to 1.130); Q3, 1.077 (1.018 to 1.138); Q4, 1.203 (1.139 to 1.270)) even after adjusting for confounding factors including mean eGFR and mean fasting plasma glucose levels. The subgroup analyses according to risk factors as well as analyses using eGFR-CV, eGFR-SD and eGFR-ARV showed consistent results. The association between increased eGFR variability and type 2 diabetes risk was more prominent in men, individuals with dyslipidemia and those with CKD as shown in the subgroup analysis (p for interaction <0.001).ConclusionsIncreased eGFR variability may be an independent predictor of type 2 diabetes and might be useful for risk stratification of individuals without diabetes.

scholarly journals Comment on: Schmidt MI, Duncan BB, Vigo A et al (2006) Leptin and incident type 2 diabetes: risk or protection? Diabetologia 49:2086–2096

Diabetologia ◽  
2006 ◽  
Vol 50 (1) ◽  
pp. 234-236 ◽  
Author(s):  
M. B. Snijder ◽  
J. M. Dekker ◽  
L. M. Bouter ◽  
R. J. Heine ◽  
C. D. A. Stehouwer ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetes Risk ◽  
Incident Type ◽  
Incident Type 2 Diabetes

scholarly journals Association of a Dietary Score with Incident Type 2 Diabetes: The Dietary-Based Diabetes-Risk Score (DDS)

PLoS ONE ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. e0141760 ◽  
Author(s):  
Ligia J. Dominguez ◽  
Maira Bes-Rastrollo ◽  
Francisco Javier Basterra-Gortari ◽  
Alfredo Gea ◽  
Mario Barbagallo ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Risk Score ◽  
Diabetes Risk ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
Dietary Score ◽  
Diabetes Risk Score

scholarly journals Associations of Ultra-Processed Food and Its Underlying Consumption Patterns With Incident Type 2 Diabetes: The Lifelines Cohort Study

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 402-402
Author(s):  
Ming-Jie Duan ◽  
Petra C Vinke ◽  
Gerjan Navis ◽  
Eva Corpeleijn ◽  
Louise Dekker
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Principal Component ◽  
Diabetes Risk ◽  
Consumption Patterns ◽  
Inverse Association ◽  
Processed Food ◽  
Incident Type ◽  
Incident Type 2 Diabetes

Abstract Objectives Although consumption of ultra-processed food (UPF) has previously been associated with adverse health outcomes, it is unclear how the consumption of UPF and its underlying habitual consumption patterns are associated with incident type 2 diabetes. Methods In 70 421 participants (35–70 years, 58.6% women) from the Lifelines cohort study, dietary intake was assessed with a food frequency questionnaire. Principal component analysis (PCA) was performed to derive UPF consumption patterns. UPF was related to incident diabetes with adjustments for confounders, including overall diet quality. Results During a median follow-up of 41 months, the intake of UPF was associated with higher risk of type 2 diabetes (1128 cases, OR for a 10% increment in UPF intake 1.33 [95% CI 1.26, 1.41]), and remained significant after adjustment for confounders (OR 1.25 [95% CI 1.16, 1.34]). PCA revealed four habitual UPF consumption patterns. A pattern high in cold savory snacks (OR 1.16 [95% CI 1.09, 1.22]) and a pattern high in warm savory snacks (OR 1.15 [95% CI 1.08, 1.21]) were associated with an increased diabetes risk; a pattern high in traditional Dutch cuisine was not associated with diabetes risk (OR 1.05 [95% CI 0.97, 1.14]); while a pattern high in sweet snacks and pastries was inversely associated with diabetes risk (OR 0.82 [95% CI 0.76, 0.89]). There was a clear inverse association between diabetes risk at baseline and the sweet snacks and pastries pattern (β = −0.104 [95% CI − 0.113, −0.094]). Conclusions A higher consumption of UPF was associated with higher risk of type 2 diabetes. For consumption patterns, this association was most pronounced for the patterns that were high in savory snacks. Our findings emphasize that in addition to promoting the consumption of healthy food products, discouraging the consumption of UPF, specifically savory snacks, should be considered as part of future diabetes prevention strategies. Funding Sources This project has received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 754425.

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