scholarly journals The role of global and regional DNA methylation and histone modifications in glycemic traits and type 2 diabetes: A systematic review

2016 ◽  
Vol 26 (7) ◽  
pp. 553-566 ◽  
Author(s):  
T. Muka ◽  
J. Nano ◽  
T. Voortman ◽  
K.V.E. Braun ◽  
S. Ligthart ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Dna Methylation ◽  
Histone Modifications

scholarly journals The Role of Aerobic Training Variables Progression on Glycemic Control of Patients with Type 2 Diabetes: a Systematic Review with Meta-analysis

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Rodrigo Sudatti Delevatti ◽  
Cláudia Gomes Bracht ◽  
Salime Donida Chedid Lisboa ◽  
Rochelle Rocha Costa ◽  
Elisa Corrêa Marson ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Aerobic Training ◽  
Meta Analysis

scholarly journals The Inclusion of Ethnic Minority Patients and the Role of Language in Telehealth Trials for Type 2 Diabetes: A Systematic Review

2016 ◽  
Vol 18 (9) ◽  
pp. e256 ◽  
Author(s):  
Talia Isaacs ◽  
Daniel Hunt ◽  
Danielle Ward ◽  
Leila Rooshenas ◽  
Louisa Edwards
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Ethnic Minority

scholarly journals On the Role of Spirituality and Religiosity in Type 2 Diabetes Mellitus Management—A Systematic Review

Psychology ◽  
2018 ◽  
Vol 09 (04) ◽  
pp. 728-744 ◽  
Author(s):  
Panagiota Darvyri ◽  
Stavros Christodoulakis ◽  
Michael Galanakis ◽  
Adamantios G. Avgoustidis ◽  
Anastasia Thanopoulou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetes Mellitus Management

scholarly journals The Role of DNA Methylation and Histone Modification in Periodontal Disease: A Systematic Review

2020 ◽  
Vol 21 (17) ◽  
pp. 6217
Author(s):  
Ismael Khouly ◽  
Rosalie Salus Braun ◽  
Michelle Ordway ◽  
Bradley Eric Aouizerat ◽  
Iya Ghassib ◽  
...  
Keyword(s):  
Systematic Review ◽  
Dna Methylation ◽  
Periodontal Disease ◽  
Histone Modification ◽  
Histone Modifications ◽  
Disease Risk ◽  
Periodontal Diseases ◽  
Epigenetic Changes ◽  
Human Adults

Despite a number of reports in the literature on the role of epigenetic mechanisms in periodontal disease, a thorough assessment of the published studies is warranted to better comprehend the evidence on the relationship between epigenetic changes and periodontal disease and its treatment. Therefore, the aim of this systematic review is to identify and synthesize the evidence for an association between DNA methylation/histone modification and periodontal disease and its treatment in human adults. A systematic search was independently conducted to identify articles meeting the inclusion criteria. DNA methylation and histone modifications associated with periodontal diseases, gene expression, epigenetic changes after periodontal therapy, and the association between epigenetics and clinical parameters were evaluated. Sixteen studies were identified. All included studies examined DNA modifications in relation to periodontitis, and none of the studies examined histone modifications. Substantial variation regarding the reporting of sample sizes and patient characteristics, statistical analyses, and methodology, was found. There was some evidence, albeit inconsistent, for an association between DNA methylation and periodontal disease. IL6, IL6R, IFNG, PTGS2, SOCS1, and TNF were identified as candidate genes that have been assessed for DNA methylation in periodontitis. While several included studies found associations between methylation levels and periodontal disease risk, there is insufficient evidence to support or refute an association between DNA methylation and periodontal disease/therapy in human adults. Further research must be conducted to identify reproducible epigenetic markers and determine the extent to which DNA methylation can be applied as a clinical biomarker.

scholarly journals Epigenetics and gestational diabetes: a review of epigenetic epidemiology studies and their use to explore epigenetic mediation and improve prediction

Diabetologia ◽  
2019 ◽  
Vol 62 (12) ◽  
pp. 2171-2178 ◽  
Author(s):  
Hannah R. Elliott ◽  
Gemma C. Sharp ◽  
Caroline L. Relton ◽  
Deborah A. Lawlor
Keyword(s):  
Type 2 Diabetes ◽  
Dna Methylation ◽  
Gestational Diabetes ◽  
Histone Modification ◽  
Diabetes Research ◽  
Epigenetic Mechanisms ◽  
Epigenetic Epidemiology ◽  
Epigenetic Biomarkers

Abstract Epigenetics encapsulates a group of molecular mechanisms including DNA methylation, histone modification and microRNAs (miRNAs). Gestational diabetes (GDM) increases the risk of adverse perinatal outcomes and is associated with future offspring risk of obesity and type 2 diabetes. It has been hypothesised that epigenetic mechanisms mediate an effect of GDM on offspring adiposity and type 2 diabetes and this could provide a modifiable mechanism to reduce type 2 diabetes in the next generation. Evidence for this hypothesis is lacking. Epigenetic epidemiology could also contribute to reducing type 2 diabetes by identifying biomarkers that accurately predict risk of GDM and its associated future adverse outcomes. We reviewed published human studies that explored associations between any of maternal GDM, type 2 diabetes, gestational fasting or post-load glucose and any epigenetic marker (DNA methylation, histone modification or miRNA). Of the 81 relevant studies we identified, most focused on the potential role of epigenetic mechanisms in mediating intrauterine effects of GDM on offspring outcomes. Studies were small (median total number of participants 58; median number of GDM cases 27) and most did not attempt replication. The most common epigenetic measure analysed was DNA methylation. Most studies that aimed to explore epigenetic mediation examined associations of in utero exposure to GDM with offspring cord or infant blood/placenta DNA methylation. Exploration of any causal effect, or effect on downstream offspring outcomes, was lacking. There is a need for more robust methods to explore the role of epigenetic mechanisms as possible mediators of effects of exposure to GDM on future risk of obesity and type 2 diabetes. Research to identify epigenetic biomarkers to improve identification of women at risk of GDM and its associated adverse (maternal and offspring) outcomes is currently rare but could contribute to future tools for accurate risk stratification.

scholarly journals DNA methylation markers associated with type 2 diabetes, fasting glucose and HbA1c levels: a systematic review and replication in a case–control sample of the Lifelines study

Diabetologia ◽  
2017 ◽  
Vol 61 (2) ◽  
pp. 354-368 ◽  
Author(s):  
Eliza Walaszczyk ◽  
Mirjam Luijten ◽  
Annemieke M. W. Spijkerman ◽  
Marc J. Bonder ◽  
Helen L. Lutgers ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Dna Methylation ◽  
Fasting Glucose ◽  
Control Sample ◽  
Case Control ◽  
Hba1c Levels

scholarly journals The role of DNA methylation and histone modifications in blood pressure: a systematic review

2019 ◽  
Vol 33 (10) ◽  
pp. 703-715 ◽  
Author(s):  
Valentina Gonzalez-Jaramillo ◽  
Eliana Portilla-Fernandez ◽  
Marija Glisic ◽  
Trudy Voortman ◽  
Wichor Bramer ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Dna Methylation ◽  
Histone Modifications
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