Pro- and anti-inflammatory cytokine gene expression in subcutaneous and visceral fat in severe obesity

2014 ◽  
Vol 24 (10) ◽  
pp. 1137-1143 ◽  
Author(s):  
B. Spoto ◽  
E. Di Betta ◽  
F. Mattace-Raso ◽  
E. Sijbrands ◽  
A. Vilardi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Visceral Fat ◽  
Inflammatory Cytokine ◽  
Severe Obesity ◽  
Cytokine Gene Expression ◽  
Cytokine Gene ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

scholarly journals Effects of prepartum oilseed supplements on subclinical endometritis, pro- and anti-inflammatory cytokine transcripts in endometrial cells and postpartum ovarian function in dairy cows

2017 ◽  
Vol 29 (4) ◽  
pp. 747 ◽  
Author(s):  
Reza Salehi ◽  
Marcos G. Colazo ◽  
Mohanathas Gobikrushanth ◽  
Urmila Basu ◽  
Divakar J. Ambrose
Keyword(s):  
Dairy Cows ◽  
Sunflower Seed ◽  
Inflammatory Cytokine ◽  
Ovarian Function ◽  
Cytokine Gene Expression ◽  
Cytokine Gene ◽  
Endometrial Cells ◽  
Anti Inflammatory ◽  
Subclinical Endometritis ◽  
Anti Inflammatory Cytokine

Postpartum uterine infections affect ovarian function and delay ovulation in cattle. As dietary fats can affect immune cell function, we investigated the influence of prepartum diets on postpartum uterine inflammatory status (UIS) as assessed 25 ± 1 days postpartum by endometrial cytology (normal: ≤8% polymorphonuclear cells (PMN) vs subclinical endometritis (SCE): >8% PMN) and associations between SCE, pro- and anti-inflammatory cytokine gene expression and ovarian function. During the last 5 weeks of gestation, dairy cows received a diet supplemented with 8% rolled sunflower (n = 10) or canola seed (n = 9) or no oilseed (n = 9). Ovaries were scanned until 35 days postpartum. Prepartum diets did not influence SCE, but a preovulatory-size follicle developed sooner (P ≤ 0.05), the interval to first ovulation was shorter and the proportion of cows ovulating within 35 days postpartum was greater in the sunflower seed group. Although mRNA expression of cytokines was not affected by diet, cows with SCE had higher (P ≤ 0.05) expression of interleukin-1β (IL1B), interleukin-8 (CXCL8), IL10 and tumour necrosis factor-α (TNF) than normal cows. The interval (mean ± s.e.m.) from calving to preovulatory-size follicle was shorter (P ≤ 0.05) in normal (13.2 ± 0.9 days) than SCE cows (18.7 ± 1.4 days). In summary, a prepartum diet supplemented with sunflower seed positively influenced postpartum ovarian function without affecting UIS or pro- and anti-inflammatory cytokine gene expression in endometrial cells.

scholarly journals Inflammation modulates regeneration in the acute or chronically damaged zebrafish retina

2021 ◽  
Author(s):  
Maria Iribarne ◽  
David Hyde
Keyword(s):  
Gene Expression ◽  
Inflammatory Cytokine ◽  
Gold Rush ◽  
Cytokine Gene Expression ◽  
Retinal Damage ◽  
Cytokine Gene ◽  
Reactive Microglia ◽  
Cytokine Genes ◽  
Tnf Α ◽  
Anti Inflammatory

Unlike mammals, zebrafish regenerate in response to retinal damage. Because microglia are activated by retinal damage, we investigated their role during regeneration following acute or chronic damage. At three weeks-post-fertilization (wpf), fish exhibiting NMDA-induced acute damage or cone photoreceptor-specific chronic degeneration, the gold rush (gosh) mutant, displayed reactive microglia and Müller glia proliferation. Retinas treated to inhibit the immune response lacked reactive microglia and possessed fewer PCNA-positive cells, while LPS treatment increased microglia and PCNA-labeled cells. NMDA-injured retinas upregulated the expression of il-1β and tnf-α pro-inflammatory cytokine genes, followed by increased expression of il-10 and arg1 anti-inflammatory/remodeling cytokine genes. An early and transiently TNF-α pro-inflammatory microglia population was identified in the NMDA-damaged retina. In contrast, gosh mutant retinas exhibited a mild increase of pro-inflammatory cytokine gene expression concurrently with a greater increased in anti-inflammatory/remodeling cytokine gene expression. Few TNF-α pro-inflammatory microglia were observed in the gosh retina. How inflammation regulates regeneration in zebrafish would provide important clues towards improving the therapeutic strategies for repairing injured mammalian tissues.

scholarly journals Rice Bran Protein Hydrolysates Improve Insulin Resistance and Decrease Pro-inflammatory Cytokine Gene Expression in Rats Fed a High Carbohydrate-High Fat Diet

Nutrients ◽  
2015 ◽  
Vol 7 (8) ◽  
pp. 6313-6329 ◽  
Author(s):  
Kampeebhorn Boonloh ◽  
Veerapol Kukongviriyapan ◽  
Bunkerd Kongyingyoes ◽  
Upa Kukongviriyapan ◽  
Supawan Thawornchinsombut ◽  
...  
Keyword(s):  
Gene Expression ◽  
Insulin Resistance ◽  
Rice Bran ◽  
High Fat Diet ◽  
Inflammatory Cytokine ◽  
Cytokine Gene Expression ◽  
Cytokine Gene ◽  
High Fat ◽  
High Carbohydrate ◽  
Improve Insulin Resistance
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