Serum uric acid and its relationship with metabolic syndrome and cardiovascular risk profile in patients with hypertension: Insights from the I-DEMAND study

2014 ◽  
Vol 24 (8) ◽  
pp. 921-927 ◽  
Author(s):  
F. Viazzi ◽  
D. Garneri ◽  
G. Leoncini ◽  
A. Gonnella ◽  
M.L. Muiesan ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Uric Acid ◽  
Cardiovascular Risk ◽  
Serum Uric Acid ◽  
Risk Profile ◽  
Cardiovascular Risk Profile

scholarly journals Serum uric acid is no more a by-stander for risk of cardiovascular diseases in metabolic syndrome: a prospective study

2021 ◽  
Vol 8 (6) ◽  
pp. 788
Author(s):  
Anirudh Kumar Allam ◽  
Chandrakant Chavan ◽  
Rahul Mandole ◽  
Jagdish Hiremath ◽  
Vikrant Khese
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Uric Acid ◽  
Cardiovascular Risk ◽  
Cardiovascular Diseases ◽  
Serum Uric Acid ◽  
Serum Uric Acid Level ◽  
Worldwide Population ◽  
Study Population ◽  
A Prospective Study

Background: Cardiovascular diseases have become the fastest growing health issue in India and worldwide. Population with metabolic syndrome is known to be pre-disposed to several chronic disorders along with higher risk of experiencing cardiovascular events. The role of uric acid as a cardiovascular risk factor in metabolic syndrome was not well studied in the literature, which made us to undertake the present study.Methods: All the patients aged between 18 to 75 years (both gender) who approached Madhavbaug cardiac care clinics located in Maharashtra, India for assessing risk of heart disease from January 2015 to January 2017 were screened. Risk factors for metabolic syndrome have been evaluated among the study population and categorised into metabolic syndrome positive (³3 risk factors) and negative groups (<3 risk factors). Statistical analysis was done using SPSS software version: 21.0.Results: Our study includes 2294 subjects who met the inclusion and exclusion criteria. Males outnumbered the females and sex ratio was 2.89:1. Females had lower serum uric acid levels compared to males irrespective of metabolic component. Gender and serum uric acid levels (high and low) were used stratification of the subjects. Serum uric acid is an independent predictor of cardiovascular diseases with an Odds ratio of 1.13 (95% confidence interval).Conclusions: Serum uric acid level is one of the important predictor for cardiovascular risk in metabolic syndrome. Raised uric acid is not an innocent by-stander and one of the major contributors in development of cardiovascular diseases.

The metabolic syndrome is amplified in hypothyroid rheumatoid arthritis patients: a cross-sectional study

2008 ◽  
Vol 69 (01) ◽  
pp. 39-42 ◽  
Author(s):  
H G Raterman ◽  
I C van Eijk ◽  
A E Voskuyl ◽  
M J L Peters ◽  
B A C Dijkmans ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Metabolic Syndrome ◽  
Cardiovascular Risk ◽  
Risk Score ◽  
Framingham Risk Score ◽  
Risk Profile ◽  
Cardiovascular Risk Profile ◽  
Prevalence Odds Ratio ◽  
The Metabolic Syndrome ◽  
Framingham Risk

Objectives:Rheumatoid arthritis (RA) patients are at increased risk of cardiovascular disease (CVD), which is even more pronounced in hypothyroid RA patients. An unfavourable cardiovascular risk profile conferred by a higher prevalence of the metabolic syndrome (MetS) and a higher Framingham risk score might explain this amplified cardiovascular morbidity. This study compared first, MetS (features) and second, the Framingham 10-year CVD risk in RA patients with hypothyroidism compared with euthyroid RA patients.Methods:RA patients participating in the CARRÉ investigation were divided into two groups: hypothyroid and euthyroid RA patients. MetS according to the National Cholesterol Education Program Third Adult Treatment Panel criteria and the Framingham risk score was compared between hypothyroid and non-hypothyroid CVD event-free RA patients.Results:In total, 257 RA patients were included: 236 with RA (91.8%) and 21 with hypothyroid RA (8.2%), respectively. The prevalence of the MetS was significantly higher in hypothyroid RA patients (43%) compared with RA patients (20%). Moreover, female hypothyroid RA patients had a higher Framingham risk score compared with euthyroid RA patients. With RA patients as the reference category, the age and gender-adjusted prevalence odds ratio for the MetS was 3.5 (95% CI 1.3 to 9.1) in hypothyroid RA.Conclusions:Hypothyroid RA patients, particularly female patients, have a more unfavourable cardiovascular risk profile, reflected by an increased prevalence of the MetS and higher Framingham score, than euthyroid RA patients, suggesting a greater need for cardiovascular risk management in these patients to prevent future CVD events.

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