scholarly journals IRS1 gene variants, dysglycaemic metabolic changes and type-2 diabetes risk

2012 ◽  
Vol 22 (12) ◽  
pp. 1024-1030 ◽  
Author(s):  
N. Yiannakouris ◽  
J.A. Cooper ◽  
S. Shah ◽  
F. Drenos ◽  
H.A. Ireland ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetes Risk ◽  
Metabolic Changes ◽  
Gene Variants

scholarly journals Common Type 2 Diabetes Risk Gene Variants Associate with Gestational Diabetes

2009 ◽  
Vol 94 (1) ◽  
pp. 145-150 ◽  
Author(s):  
Jeannet Lauenborg ◽  
Niels Grarup ◽  
Peter Damm ◽  
Knut Borch-Johnsen ◽  
Torben Jørgensen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gestational Diabetes ◽  
Receiver Operating Characteristic ◽  
Operating Characteristic ◽  
Diabetes Risk ◽  
Gene Variants ◽  
Risk Alleles ◽  
Risk Variants ◽  
Receiver Operating

Abstract Objective: We aimed to examine the association between gestational diabetes mellitus (GDM) and 11 recently identified type 2 diabetes susceptibility loci. Research Design and Methods: Type 2 diabetes risk variants in TCF7L2, CDKAL1, SLC30A8, HHEX/IDE, CDKN2A/2B, IGF2BP2, FTO, TCF2, PPARG, KCNJ11, and WFS1 loci were genotyped in a cohort of women with a history of GDM (n = 283) and glucose-tolerant women of the population-based Inter99 cohort (n = 2446). Results: All the risk alleles in the 11 examined type 2 diabetes risk variants showed an odds ratio (OR) greater than 1 for the GDM group compared with the control group ranging from 1.13 [95% confidence interval (CI) 0.88–1.46] to 1.44 (95% CI 1.19–1.74) except for the WFS1 rs10010131 variant with OR 0.87 (95% CI 0.73–1.05). Combined analysis of all 11 variants showed a highly significant additive effect of multiple risk alleles on risk of GDM [OR 1.18 (95% CI 1.10–1.27)] per risk allele, P = 3.2 × 10−6). Applying receiver-operating characteristic showed an area under the receiver-operating characteristic curve of 0.62 for the genetic test alone and 0.73 when combining information on age, body mass index, and genotypes of the 11 gene variants. Conclusions: The prevalence in a prior GDM group of several previously proven type 2 diabetes risk alleles equals the findings from association studies on type 2 diabetes. This supports the hypothesis that GDM and type 2 diabetes are two of the same entity.

scholarly journals Impact of common type 2 diabetes risk gene variants on future type 2 diabetes in the non-diabetic population in Korea

2012 ◽  
Vol 57 (4) ◽  
pp. 265-268 ◽  
Author(s):  
Se Eun Park ◽  
Won Young Lee ◽  
Ki Won Oh ◽  
Ki Hyun Baek ◽  
Kun Ho Yoon ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Common Type ◽  
Diabetes Risk ◽  
Gene Variants ◽  
Risk Gene ◽  
Diabetic Population

Association of Common Type 2 Diabetes Risk Gene Variants and Posttransplantation Diabetes Mellitus in Renal Allograft Recipients in Korea

2009 ◽  
Vol 88 (5) ◽  
pp. 693-698 ◽  
Author(s):  
Eun Seok Kang ◽  
Myoung Soo Kim ◽  
Chul Hoon Kim ◽  
Chung Mo Nam ◽  
Seung Jin Han ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Renal Allograft ◽  
Common Type ◽  
Diabetes Risk ◽  
Gene Variants ◽  
Risk Gene

Smoking Tied to Greater Type 2 Diabetes Risk

2008 ◽  
Vol 38 (1) ◽  
pp. 14-15
Author(s):  
MARY ANN MOON
Keyword(s):  
Type 2 Diabetes ◽  
Diabetes Risk

Hormonal factors and type 2 diabetes risk in women: a 22 year follow-up study on more than 83 000 women from the E3N cohort study

2019 ◽  
Author(s):  
Sopio Tatulashvili ◽  
Gaelle Gusto ◽  
Beverley Balkau ◽  
Emmanuel Cosson ◽  
Fabrice Bonnet ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cohort Study ◽  
Diabetes Risk ◽  
Hormonal Factors ◽  
Follow Up Study

1532-P: Greater Type 2 Diabetes Risk among College Students in Egypt Is Alarming

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1532-P
Author(s):  
ELSAYED MOHAMED EID ◽  
SHAHEEN TOMAH ◽  
AHMED H. ELDIB ◽  
MEGAHED MOH ABOUELMAGD ◽  
EMAN M. FAHMY ◽  
...  
Keyword(s):  
College Students ◽  
Type 2 Diabetes ◽  
Diabetes Risk
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