Glycated apolipoprotein B and myocardial infarction

2007 ◽  
Vol 17 (1) ◽  
pp. 6-12 ◽  
Author(s):  
G. Misciagna ◽  
G. Logroscino ◽  
G. De Michele ◽  
V. Guerra ◽  
A.M. Cisternino ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Apolipoprotein B

scholarly journals Influence of Peripheral Artery Disease and Statin Therapy on Apolipoprotein Profiles

2013 ◽  
Vol 2013 ◽  
pp. 1-7
Author(s):  
Andrew W. Gardner ◽  
Petar Alaupovic ◽  
Donald E. Parker ◽  
Polly S. Montgomery ◽  
Omar L. Esponda ◽  
...  
Keyword(s):  
Physical Activity ◽  
Myocardial Infarction ◽  
Statin Therapy ◽  
Peripheral Artery Disease ◽  
Apolipoprotein B ◽  
Ldl Cholesterol ◽  
Risk Profile ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Plasma Apolipoprotein

Apolipoprotein B is a stronger predictor of myocardial infarction than LDL cholesterol, and it is inversely related to physical activity and modifiable with exercise training. As such, apolipoprotein measures may be of particular relevance for subjects with PAD and claudication. We compared plasma apolipoprotein profiles in 29 subjects with peripheral artery disease (PAD) and intermittent claudication and in 39 control subjects. Furthermore, we compared the plasma apolipoprotein profiles of subjects with PAD either treated (n=17) or untreated (n=12) with statin medications. For the apolipoprotein subparticle analyses, subjects with PAD had higher age-adjusted Lp-B:C (P<0.05) and lower values of Lp-A-I:A-II (P<0.05) than controls. The PAD group taking statins had lower age-adjusted values for apoB (P<0.05), Lp-A-II:B:C:D:E (P<0.05), Lp-B:E + Lp-B:C:E (P<0.05), Lp-B:C (P<0.05), and Lp-A-I (P<0.05) than the untreated PAD group. Subjects with PAD have impaired apolipoprotein profiles than controls, characterized by Lp-B:C and Lp-A-I:A-II. Furthermore, subjects with PAD on statin medications have a more favorable risk profile, particularly noted in multiple apolipoprotein subparticles. The efficacy of statin therapy to improve cardiovascular risk appears more evident in the apolipoprotein sub-particle profile than in the more traditional lipid profile of subjects with PAD and claudication. This trial is registered with ClinicalTrials.govNCT00618670.

Xbal polymorphism in DNA at the apolipoprotein B locus is associated with myocardial infarction (MI)

2008 ◽  
Vol 44 (5) ◽  
pp. 241-248 ◽  
Author(s):  
M. Bøhn ◽  
A. Bakken ◽  
J. Erikssen ◽  
K. Berg
Keyword(s):  
Myocardial Infarction ◽  
Apolipoprotein B ◽  
B Locus

Lipoprotein(a) is an independent risk factor for myocardial infarction at a young age

1990 ◽  
Vol 36 (1) ◽  
pp. 20-23 ◽  
Author(s):  
M Sandkamp ◽  
H Funke ◽  
H Schulte ◽  
E Köhler ◽  
G Assmann
Keyword(s):  
Myocardial Infarction ◽  
Risk Factor ◽  
Apolipoprotein E ◽  
Apolipoprotein B ◽  
Independent Risk Factor ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Major Influence ◽  
Lipoprotein A ◽  
Apolipoprotein E Polymorphism

Abstract We quantified lipoprotein(a) [Lp(a)] immunochemically in young (less than 46 y) male survivors of myocardial infarction and in age-matched controls recruited from participants of the Prospective Cardiovascular Münster (PROCAM) study. We further determined apolipoprotein E polymorphism and measured triglycerides, total cholesterol, high- and low-density lipoprotein cholesterol (HDL and LDL), and apolipoproteins AI, AII, and B in the serum of these subjects. Lp(a) concentrations in serum were not correlated with other well-recognized risk factors for early myocardial infarction such as apolipoproteins AI and B, LDL cholesterol, and HDL cholesterol. Apolipoprotein E polymorphism did not affect Lp(a) concentrations, but had a major influence on apolipoprotein B concentration. Lp(a) concentrations were not influenced by age. Our data suggest that (a) an increased concentration of Lp(a) constitutes an independent risk factor for early myocardial infarction and (b) the concentrations of Lp(a) and LDL cholesterol (apolipoprotein B) in serum are under separate metabolic control.

Apolipoprotein B–Gene DNA Polymorphisms Associated with Myocardial Infarction

1986 ◽  
Vol 315 (24) ◽  
pp. 1509-1515 ◽  
Author(s):  
Robert A. Hegele ◽  
Li-Shin Huang ◽  
Peter N. Herbert ◽  
Conrad B. Blum ◽  
Julie E. Buring ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Apolipoprotein B ◽  
Dna Polymorphisms ◽  
Apolipoprotein B Gene

scholarly journals Correlation between Apolipoprotein B/Apolipoprotein A-I Ratio with Atherogenic Index of Plasma among Acute Myocardial Infarction Patients

2018 ◽  
Vol 10 (2) ◽  
pp. 179-83
Author(s):  
Winardi Emmanuel Setiawan ◽  
Anggoro Budi Hartopo ◽  
Royhan Rozqie
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Lipid Profile ◽  
Apolipoprotein B ◽  
Pearson Correlation ◽  
Atherogenic Index ◽  
Simple Method ◽  
Atherogenic Index Of Plasma ◽  
Blood Samples ◽  
Apolipoprotein A

BACKGROUND: Acute myocardial infarction (AMI) is the most common cause of death in the world. One preventive attempt to reduce AMI is early detection of blood lipid profile. A simple method of lipid profile assessment is the measurement of atherogenic index of plasma (AIP), meanwhile more accurate method of lipid profile assessment is the measurement of apolipoprotein B/apolipoprotien A-I (ApoB/ApoAI) ratio. However, whether both measurements are interchangeable is need to be investigated. This study aims to investigate the correlation between AIP value and ApoB/ApoAI ratio in patients with AMI.METHODS: The study design was cross-sectional study. The blood samples of consecutively enrolled AMI patients had been selected after inclusion and exclusion criteria. The blood samples were taken within 24 hours of patient admission to the hospital. The blood concentration of high-density lipoprotein (HDL) and triglycerides (TG) were measured using turbidimetric method. The AIP was calculated as logarithmic of TG/HDL ratio (log10.[TG:HDL]) The concentration of ApoB and ApoAI were measured using immunoturbidimetric method. The correlation between these measurements was analyzed with Pearson correlation test.RESULTS: The blood samples of 76 subjects were collected and analyzed. The subjects were dominated by male (n=67, 88%) and those whose age ≥55 years old (n=54, 71%). The mean ApoB value was 88.66 mg/dL and ApoAI was 97.39 mg/dL. The AIP value was 0.05. The Pearson correlation test between AIP and ApoB/ApoAI ratio showed a significant positive correlation with the strength of correlation was moderate (r=0.51, p-value<0.01).CONCLUSION: There was a significantly positive and moderate correlation between AIP value and ApoB/ApoAI ratio in acute myocardial infarction patients.KEYWORDS: atherogenic index of plasma, acute myocardial infarction, apolipoprotein B/apolipoprotein A-I ratio

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