Insulin glargine improves glycemic control and health-related quality of life in type 1 diabetes

2007 ◽  
Vol 17 (7) ◽  
pp. 493-498 ◽  
Author(s):  
Rita Manini ◽  
Gabriele Forlani ◽  
Simona Moscatiello ◽  
Chiara Zannoni ◽  
Rebecca Marzocchi ◽  
...  
2021 ◽  
Author(s):  
Rossana Sousa Azulay ◽  
Débora Lago ◽  
Glaucia Abreu Silva Santos ◽  
Maria da Gloria Tavares ◽  
Vandilson Rodrigues ◽  
...  

Abstract BACKGROUND: Type 1 diabetes is a chronic disease of an autoimmune character that affects the quality of life of patients in different degrees. Race and socioeconomic differences directly affect glycemic control. This study aimed to evaluate the Health-related quality of life (HRQoL) of Type 1 diabetes mellitus (T1D) patients an admixed Brazilian population, and to identify the variables influencing this condition.METHODS: This research is a cross-sectional study conducted at the University Hospital-Federal University of Maranhão Endocrinology Service with 152 T1D patients between 2017 and 2018. HRQoL information was obtained from two self-completed questionnaires: Short Form-6 dimensions and EuroQol-5 dimensions with visual analog scale. For inference of autosomal ancestry, a panel of 46 autosomal informational insertion/deletion ancestry markers (AIM–Indels) was used. Demographic information, socioeconomic data, presence of chronic complications, glycemic control level, and type of treatment were collected.RESULTS: In the study, the patients who had good HRQoL were characterized as follows: male, under 18 years old, single, with average of 11 years of schooling, had health insurance, with less than 5 years of diagnosis, practiced physical activity, experienced no hypoglycemia in the last 30 days, reported no chronic complications (retinopathy and nephropathy), participant in several group educational activities, used analogous insulin, monitored blood glucose, showed maximum treatment adherence, and came from the secondary service. Autosomal ancestry and self-reported color/race did not show influence on HRQoL indexes.CONCLUSION: Our study is the first to measure the HRQoL, autosomal ancestry and recognize the impact of T1D on patients' lives in the State of Maranhão, Northeast of Brazil. The results validate the need to provide T1D patients with continuous training on self-management and self-monitoring, seeking better results in metabolic control and consequently, in the prevention of acute and chronic complications to generate positive impacts on the quality of life of this population. In addition, reinforcing physical activity at each appointment should be part of the health team’s routine. We understand that ethnicity in a highly mixed population like ours did not influence the quality of life of these patients.


2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Ana Carolina Contente Braga de Souza ◽  
◽  
João Soares Felício ◽  
Camila Cavalcante Koury ◽  
João Felício Abrahão Neto ◽  
...  

2018 ◽  
Vol 19 (8) ◽  
pp. 1481-1486 ◽  
Author(s):  
Andrea Lukács ◽  
Krisztina Mayer ◽  
Péter Sasvári ◽  
László Barkai

Author(s):  
Marisa E Hilliard ◽  
Charles G Minard ◽  
David G Marrero ◽  
Maartje de Wit ◽  
Debbe Thompson ◽  
...  

Abstract Objective To develop and validate new measures of diabetes-specific health-related quality of life (HRQOL) for people with type 1 diabetes (T1D) that are brief, developmentally appropriate, and usable in clinical research and care. Here we report on the phases of developing and validating the self-report Type 1 Diabetes and Life (T1DAL) measures for children (age 8–11) and adolescents (age 12–17). Methods Measure development included qualitative interviews with youth and parents (n = 16 dyads) followed by piloting draft measures and conducting cognitive debriefing with youth (n = 9) to refine the measures. To evaluate the psychometric properties, children (n = 194) and adolescents (n = 257) at three T1D Exchange Clinic Network sites completed the age-appropriate T1DAL measure and previously validated questionnaires measuring related constructs. Using psychometric data, the investigators reduced the length of each T1DAL measure to 21 and 23 items, respectively, and conducted a final round of cognitive debriefing with six children and adolescents. Results The T1DAL measures for children and adolescents demonstrated good internal consistency (α = 0.84 and 0.89, respectively) and test–retest reliability (r = 0.78 and 0.80, respectively). Significant correlations between the T1DAL scores and measures of general quality of life, generic and diabetes-specific HRQOL, diabetes burden, and diabetes strengths demonstrated construct validity. Correlations with measures of self-management (child and adolescent) and glycemic control (adolescent only) demonstrated criterion validity. Factor analyses indicated four developmentally specific subscales per measure. Participants reported satisfaction with the measures. Conclusions The new T1DAL measures for children and adolescents with T1D are reliable, valid, and suitable for use in care settings and clinical research.


2017 ◽  
Vol 7 (10) ◽  
pp. 73 ◽  
Author(s):  
Marzoka A. Gadallah ◽  
Taghreed Abdul-Aziz M. Ismail ◽  
Naglaa Saad Abdel Aty

Objective: Health related quality of life (HRQOL) is a multidimensional construct that includes physical and psychosocial functioning, has emerged as an important outcome in pediatric population with chronic health conditions. The study objectives are to measure the quality of life among children with type I diabetes compared to healthy peers and to determine factors affecting the QOL among children with type I diabetes.Methods: Analytic cross sectional study was conducted in Sidi Galal health insurance outpatient clinic for children with type 1 diabetes mellitus and a comparison group of healthy peers was taken from other outpatient clinics. A total of four hundred and twelve children, aged from 8-18 years with type 1 diabetes and four hundred and twelve healthy peers matched in age and sex were interviewed. Three tools were used for this study: Demographic questionnaire, Socio-economic scale, and Peds QL4.0 Generic Core Scale was used to measure HRQOL.Results: The mean age of studied children was 12.9 ± 3.2. More than 60% of children with diabetes had uncontrolled glycemic level and 60% of them were in low socio-economic level. Children with diabetes had significantly lower HRQOL than healthy children in all domains. Age, glycemic control status and birth order of the diabetic children showed no significance difference regarding the QOL. Disease duration affected only the emotional function of the QOL and females showed significantly higher score regarding school functioning. Social, school and the total QOL scores were significantly higher among children with highly educated mothers while father's education affected the emotional, school and total QOL scores. Children in the middle and high social class showed significantly higher scores regarding social, school and total QOL. Presence of diabetic parent positively affected the social functioning while had negative effect on the school function of children with type I diabetes.Conclusions and recommendations: Diabetes is negatively affecting all the QOL functioning of the children. We recommend that Integrated programs between child's home, school and health insurance clinics for educating and supporting children with diabetes to improve their HRQOL.


Author(s):  
Mira Samardzic ◽  
Husref Tahirovic ◽  
Natasa Popovic ◽  
Milena Popovic-Samardzic

AbstractThe aim of this study was to evaluate health-related quality of life (HRQOL) in children and adolescents with type 1 diabetes (TIDM) in Montenegro compared with healthy controls and to estimate the effect of metabolic control on perceptions of HRQOL.This study involved children and adolescents with T1DM, age- and gender-matched healthy children and their parents. Children and adolescents with T1DM and their parents completed Peds QL 4.0 Generic Core Scales (GCS) and PedsQL 3.0 Diabetes Module. Healthy children and their parents completed self- and proxy-report of Peds QL 4.0 GCS.Our study (self- and proxy-report) showed that children and adolescents with T1DM had lower HRQOL on domain “Psychosocial health” and “School functioning” compared with healthy population (p=0.008; p≤0.001). Lower glycosylated hemoglobin (HbACompared with the healthy children, the HRQOL was lower among children and adolescents with T1DM. Lower HbA


2016 ◽  
Vol 114 ◽  
pp. 173-179 ◽  
Author(s):  
Fadia AlBuhairan ◽  
Maliha Nasim ◽  
Ahlam Al Otaibi ◽  
Naila A. Shaheen ◽  
Saleh Al Jaser ◽  
...  

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