Variation in the cholesteryl ester transfer protein (CETP) gene does not influence individual plasma cholesterol response to changes in the nature of dietary fat

2006 ◽  
Vol 16 (5) ◽  
pp. 353-363 ◽  
Author(s):  
Wendy A.E. Aitken ◽  
Alexandra W.-A.H. Chisholm ◽  
Ashley W. Duncan ◽  
Michelle J. Harper ◽  
Steve E. Humphries ◽  
...  
Keyword(s):  
Cholesteryl Ester ◽  
Cholesteryl Ester Transfer Protein ◽  
Dietary Fat ◽  
Plasma Cholesterol ◽  
Transfer Protein

Cholesteryl Ester Transfer Protein Inhibitors

2016 ◽  
Vol 22 (2) ◽  
pp. 99-104 ◽  
Author(s):  
Julian Hardy McLain ◽  
Andrew Jacob Alsterda ◽  
Rohit R. Arora
Keyword(s):  
Cholesteryl Ester ◽  
Cholesteryl Ester Transfer Protein ◽  
Plasma Cholesterol ◽  
Genetic Research ◽  
Plasma Lipoproteins ◽  
Pharmacologic Therapy ◽  
Atherosclerotic Cardiovascular Disease ◽  
Current Standard ◽  
Transfer Protein ◽  
Cetp Inhibitors

The cholesteryl ester transfer protein (CETP) is a plasma protein that plays an important role in the transfer of lipids between plasma lipoproteins. The CETP inhibitors have been widely studied as a pharmacologic therapy to target plasma cholesterol in order to reduce the risk of atherosclerotic cardiovascular disease . Using CETP inhibitors as cholesterol modifiers was based on the genetic research that found correlations between CETP activity and cholesterol levels. Although CETP inhibitors are successful at altering targeted cholesterol markers, recent phase 3 outcome trials have shown limited benefit on cardiovascular outcomes when combined with the current standard of care. We discuss the science of CETP inhibition, compare the CETP inhibitors developed (torcetrapib, evacetrapib, dalcetrapib, and anacetrapib), the findings from the CETP inhibitor trials, and the future outlook for CETP inhibitors in cholesterol modification.

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