Treatment-resistant obsessive-compulsive disorder: Insights from an open trial of transcranial direct current stimulation (tDCS) to design a RCT

2016 ◽  
Vol 22 (3-4) ◽  
pp. 146-154 ◽  
Author(s):  
Wayne M. Dinn ◽  
Ayse Aycicegi-Dinn ◽  
Fatma Göral ◽  
Sacit Karamursel ◽  
Ejder Akgun Yildirim ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Open Trial ◽  
Treatment Resistant ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Direct Current Stimulation

scholarly journals Protocol for Transcranial Direct Current Stimulation for Obsessive-Compulsive Disorder

2020 ◽  
Vol 10 (12) ◽  
pp. 1008
Author(s):  
Peta E. Green ◽  
Andrea Loftus ◽  
Rebecca A. Anderson
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Controlled Trial ◽  
Treatment Modalities ◽  
Treatment Resistant ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Direct Current Stimulation

Obsessive-compulsive disorder (OCD) is a debilitating disorder with an approximate lifetime prevalence of 1–3%. Despite advances in leading treatment modalities, including pharmacotherapy and psychotherapy, some cases remain treatment resistant. Non-invasive brain stimulation has been explored in this treatment-resistant population with some promising findings; however, a lack of methodological rigor has reduced the quality of the findings. The current paper presents the protocol for conducting research into the efficacy of transcranial direct current stimulation (tDCS) in the treatment of OCD. A double-blind randomised controlled trial (RCT) will be conducted involving active tDCS vs. sham tDCS on 40 general OCD patients. The intervention consists of 2 mA anodal stimulation over the pre-supplementary motor area (pre-SMA) with the cathode positioned over the orbitofrontal cortex (OFC). Participants will receive 10 sessions of 20 min of either sham- or active-tDCS over 4 weeks. Outcomes will be categorical and dimensional measures of OCD, as well as related secondary clinical measures (depression, anxiety, quality of life), and neurocognitive functions (inhibitory control, cognitive flexibility).

scholarly journals Transcranial Direct Current Stimulation for Obsessive-Compulsive Disorder: A Systematic Review

2018 ◽  
Vol 8 (2) ◽  
pp. 37 ◽  
Author(s):  
Jérôme Brunelin ◽  
Marine Mondino ◽  
Rémy Bation ◽  
Ulrich Palm ◽  
Mohamed Saoud ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Controlled Study ◽  
Treatment Resistant ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Direct Current Stimulation ◽  
Manual Search ◽  
Pubmed Database

Despite the advances in psychopharmacology and established psychotherapeutic interventions, more than 40% of patients with obsessive-compulsive disorder (OCD) do not respond to conventional treatment approaches. Transcranial direct current stimulation (tDCS) has been recently proposed as a therapeutic tool to alleviate treatment-resistant symptoms in patients with OCD. The aim of this review was to provide a comprehensive overview of the current state of the art and future clinical applications of tDCS in patients with OCD. A literature search conducted on the PubMed database following PRISMA guidelines and completed by a manual search yielded 12 results: eight case reports, three open-label studies (with 5, 8, and 42 participants), and one randomized trial with two active conditions (12 patients). There was no sham-controlled study. A total of 77 patients received active tDCS with a large diversity of electrode montages mainly targeting the dorsolateral prefrontal cortex, the orbitofrontal cortex or the (pre-) supplementary motor area. Despite methodological limitations and the heterogeneity of stimulation parameters, tDCS appears to be a promising tool to decrease obsessive-compulsive symptoms as well as comorbid depression and anxiety in patients with treatment-resistant OCD. Further sham-controlled studies are needed to confirm these preliminary results.

scholarly journals Transcranial direct current stimulation in patients with obsessive compulsive disorder: A randomized controlled trial

2019 ◽  
Vol 62 ◽  
pp. 38-44 ◽  
Author(s):  
Rémy Bation ◽  
Marine Mondino ◽  
Florent Le Camus ◽  
Mohamed Saoud ◽  
Jerome Brunelin
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Double Blind Study ◽  
Acute Effects ◽  
Treatment Resistant ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Direct Current Stimulation ◽  
The Right

Abstract Background: Obsessive-compulsive disorder (OCD) is a severe mental disorder with poor response to the available treatments. Neuroimaging studies have identified dysfunctions within the orbito-fronto-striato-pallido-thalamic network in patients with OCD. Here, we assessed the efficacy and safety of transcranial direct current stimulation (tDCS) applied with the cathode over the orbitofrontal cortex (OFC) and the anode over the right cerebellum to decrease OCD symptoms in patients with treatment-resistant OCD. Methods: In a randomized sham-controlled double-blind study, 21 patients with OCD were assigned to receive ten 20-min sessions (two sessions per day) of either active (2 mA) or sham tDCS. The clinical symptoms were measured using the Yale-Brown Obsessive and Compulsive Scale (YBOCS). Acute effects on the symptoms were measured from baseline to immediately after the 10 tDCS sessions. Long-lasting effects were measured 1 and 3 months after the 10th tDCS session. Results: Compared with the sham tDCS, active tDCS significantly decreased OCD symptoms immediately after the 10th tDCS session (F(1,19) = 5.26, p = 0.03). However, no significant differences were observed between the active and sham groups in terms of changes in YBOCS score or the number of responders one and 3 months after tDCS. Conclusion: Despite significant acute effects, tDCS with the cathode placed over the left OFC and the anode placed over the right cerebellum was not significantly effective in inducing a long-lasting reduction of symptoms in patients with treatment-resistant OCD.

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