The role of dispersible amyloid β-protein aggregates for Alzheimer’s disease and its therapy

2012 ◽  
Vol 18 (2) ◽  
pp. 93
Author(s):  
Dietmar R. Thal ◽  
Julia Steinmetz ◽  
Marcus Fändrich ◽  
Julia Reichwald ◽  
Matthias Staufenbiel ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Protein Aggregates ◽  
Amyloid Β Protein ◽  
Β Protein

Role of elevated amyloid β protein in patients with typical late onset Alzheimer's disease

2000 ◽  
Vol 21 ◽  
pp. 136 ◽  
Author(s):  
Steven G. Younkin ◽  
Nilufer Ertekin Taner ◽  
Tiampei Xin ◽  
Matthew Baker ◽  
Linda H. Younkin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Late Onset ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein

scholarly journals Probing Mechanisms and Therapeutic Potential of γ-Secretase in Alzheimer’s Disease

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 388
Author(s):  
Michael S. Wolfe
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Potential ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Chemical Probes ◽  
Protein Substrates ◽  
Β Protein ◽  
Secretase Activity

The membrane-embedded γ-secretase complex carries out hydrolysis within the lipid bilayer in proteolyzing nearly 150 different membrane protein substrates. Among these substrates, the amyloid precursor protein (APP) has been the most studied, as generation of aggregation-prone amyloid β-protein (Aβ) is a defining feature of Alzheimer’s disease (AD). Mutations in APP and in presenilin, the catalytic component of γ-secretase, cause familial AD, strong evidence for a pathogenic role of Aβ. Substrate-based chemical probes—synthetic peptides and peptidomimetics—have been critical to unraveling the complexity of γ-secretase, and small drug-like inhibitors and modulators of γ-secretase activity have been essential for exploring the potential of the protease as a therapeutic target for Alzheimer’s disease. Such chemical probes and therapeutic prototypes will be reviewed here, with concluding commentary on the future directions in the study of this biologically important protease complex and the translation of basic findings into therapeutics.

Normal Production of the Amyloid β-Protein and the Pathogenesis of Alzheimer’s Disease

1995 ◽  
pp. 95-97
Author(s):  
Dennis J. Selkoe ◽  
Christian Haass ◽  
Michael Schlossmacher ◽  
Albert Hung ◽  
Martin Citron ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Normal Production

scholarly journals The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

PLoS ONE ◽  
2010 ◽  
Vol 5 (3) ◽  
pp. e9505 ◽  
Author(s):  
Stephanie J. Soscia ◽  
James E. Kirby ◽  
Kevin J. Washicosky ◽  
Stephanie M. Tucker ◽  
Martin Ingelsson ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Antimicrobial Peptide ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein
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