Change in muscle strength over time in spinal muscular atrophy types II and III. A long-term follow-up study

2012 ◽  
Vol 22 (12) ◽  
pp. 1069-1074 ◽  
Author(s):  
U. Werlauff ◽  
J. Vissing ◽  
B.F. Steffensen
Keyword(s):  
Muscle Strength ◽  
Spinal Muscular Atrophy ◽  
Muscular Atrophy ◽  
Follow Up Study ◽  
Long Term Follow Up ◽  
Over Time

scholarly journals Long-term follow-up of patients with type 2 and non-ambulant type 3 spinal muscular atrophy (SMA) treated with olesoxime in the OLEOS trial

2020 ◽  
Vol 30 (12) ◽  
pp. 959-969
Author(s):  
Francesco Muntoni ◽  
Enrico Bertini ◽  
Giacomo Comi ◽  
Janbernd Kirschner ◽  
Anna Lusakowska ◽  
...  
Keyword(s):  
Spinal Muscular Atrophy ◽  
Muscular Atrophy ◽  
Long Term Follow Up ◽  
Type 3

Long-term Follow-up of Spinal Fusion in Spinal Muscular Atrophy

1986 ◽  
Vol &NA; (207) ◽  
pp. 44???54 ◽  
Author(s):  
JACK O. PIASECKI ◽  
SIAVASH MAHINPOUR ◽  
DAVID B. LEVINE
Keyword(s):  
Spinal Muscular Atrophy ◽  
Spinal Fusion ◽  
Muscular Atrophy ◽  
Long Term Follow Up

scholarly journals Long-term progression in type II spinal muscular atrophy

Neurology ◽  
2019 ◽  
Vol 93 (13) ◽  
pp. e1241-e1247 ◽  
Author(s):  
Eugenio Mercuri ◽  
Simona Lucibello ◽  
Maria Carmela Pera ◽  
Sara Carnicella ◽  
Giorgia Coratti ◽  
...  
Keyword(s):  
Spinal Muscular Atrophy ◽  
Noninvasive Ventilation ◽  
Muscular Atrophy ◽  
Type Ii ◽  
Piecewise Regression ◽  
Long Term Follow Up ◽  
Slope Change ◽  
Changes Over Time

ObjectiveTo report the long-term progression in a cohort of patients with type II spinal muscular atrophy (SMA) assessed with the Hammersmith Functional Motor Scale–Expanded.MethodsSeventy-three patients (age 2.6–25 years) were included in the study. Twenty-eight of the 73 were first assessed before the age of 5 years and had been followed up for ≈5 years or longer. We observed an overall progression that was not linear. A piecewise regression analysis showed an improvement of scores in the younger patients with a point of slope change at ≈5 years of age, a decline between 5 and 13 years of age, and stability/slower decline after that.ResultsPatients with the lowest scores at baseline had the earliest onset of scoliosis and a higher need for noninvasive ventilation compared to those with higher scores. Our results confirm that on the long-term follow-up all patients with type II SMA show a clear and progressive decline.ConclusionThe severity of functional impairment at baseline can help to predict the magnitude of changes over time and the overall progression, including onset of scoliosis and need for noninvasive ventilation.

Clinical outcome of acute and chronic hepatitis delta over time: a long-term follow-up study

2011 ◽  
Vol 18 (6) ◽  
pp. 434-442 ◽  
Author(s):  
M. Buti ◽  
M. Homs ◽  
F. Rodriguez-Frias ◽  
G. Funalleras ◽  
R. Jardí ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Clinical Outcome ◽  
Hepatitis Delta ◽  
Follow Up Study ◽  
Long Term Follow Up ◽  
Acute And Chronic Hepatitis ◽  
Over Time
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