P4.10 The relationship of ataluren plasma concentration and response across clinical studies in nonsense mutation dystrophinopathy

2011 ◽  
Vol 21 (9-10) ◽  
pp. 707 ◽  
Author(s):  
R. Finkel ◽  
B. Wong ◽  
K. Bushby ◽  
T. Voit ◽  
M. Morsy ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
Clinical Studies ◽  
Nonsense Mutation ◽  
Relationship Of ◽  
The Relationship

scholarly journals Clinical Studies in the Relationship of Insanity to Crime

1916 ◽  
Vol 29 (7) ◽  
pp. 798
Author(s):  
C. P. Curtis ◽  
Paul E. Bowers
Keyword(s):  
Clinical Studies ◽  
Relationship Of ◽  
The Relationship

scholarly journals Hyperuricemia and chronic kidney disease

2021 ◽  
pp. 77-81
Author(s):  
Olga Kompaniets
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Clinical Studies ◽  
Review Of The Literature ◽  
Relationship Of ◽  
The Impact ◽  
The Relationship

The article is devoted to a review of the literature on the impact of hyperuricemia on the development and progression of chronic kidney disease (CKD). The tendency of changes of views on the role of uric acid in the pathogenesis of CKD is demonstrated. An analysis of experimental, epidemiological and clinical studies on the effects of uric acid on the physiology of the nephron and endothelial tissues, the relationship of hyperuricemia with metabolic and cardiorenal syndromes.

scholarly journals THE MOLECULAR MECHANISM OF LACTOFERRIN INFLUENCE ON BONE FORMATION

2016 ◽  
Vol 19 (3) ◽  
pp. 12-22
Author(s):  
P E Sadchikov ◽  
I L Goldman ◽  
S V Razin ◽  
A D Chernousov ◽  
L I Alekseeva ◽  
...  
Keyword(s):  
Bone Formation ◽  
Postmenopausal Osteoporosis ◽  
Critical Review ◽  
Clinical Studies ◽  
Bone Matrix ◽  
Experimental Studies ◽  
Proliferation And Differentiation ◽  
Specific Receptors ◽  
Relationship Of ◽  
The Relationship

In present critical review of systematized materials on the breakthrough achievements of the last decade - the discovery of the effect of protein lactoferrin (LF) on bone formation. It is shownthat LF increases the number of osteoblasts, stimulate their proliferation and differentiation, and prevents their destruction. Action of LF exceeds that of many other previously established bone-forming factors. LF increases the ability of osteoblasts to synthesize and mineralize bone matrix. Apparently, the effect of LF on bone anabolism ensured by the presence of specific receptors on osteoblasts. It was found that LF also inhibits the formation of osteoclasts. Experimental studies have demonstrated that LF prevents the destruction of bone tissue in ovariectomizedanimals and, thus, developing the type of postmenstrual osteoporosis in women. We get the first clinical studies demonstrating an increase in the period of healing of bone injuries while reducing the level of endogenous LF. Since molecular research establishes that the expression of the LF gene is regulated by estrogen, which reduces the development of postmenopausal osteoporosis (PMO) in women, there is a need to further investigate the relationship of these processes, which will help to create a basis for the management of bone formation.

scholarly journals A COMPARATIVE STUDY OF SUBCUTANEOUS NODULES IN RHEUMATIC FEVER AND RHEUMATOID ARTHRITIS

1933 ◽  
Vol 57 (5) ◽  
pp. 845-858 ◽  
Author(s):  
M. H. Dawson
Keyword(s):  
Rheumatoid Arthritis ◽  
Comparative Study ◽  
Rheumatic Fever ◽  
Clinical Studies ◽  
Pathological Process ◽  
Etiological Agent ◽  
Subcutaneous Nodules ◽  
Valid Evidence ◽  
Relationship Of ◽  
The Relationship

The foregoing comparative study on the subcutaneous nodules in rheumatic fever and rheumatoid arthritis is presented as part of an investigation which has been conducted in this clinic on the relationship of the two clinical entities, rheumatic fever and rheumatoid arthritis. It is believed that the present study has shown that these lesions are highly characteristic of the two diseases and that they represent different phases of the same, fundamental, pathological process. However, it should be pointed out that the presence of closely related or even identical lesions in two, separate, clinical entities cannot be considered as valid evidence in support of the hypothesis that the two diseases are etiologically related. Comparative clinical studies on the relationship of rheumatic fever and rheumatoid arthritis will be presented in a succeeding communication. These studies, as well as serological investigations on the two diseases which have been reported elsewhere (23, 24), lend further support to the conception that rheumatic fever and rheumatoid arthritis are intimately related and possibly different responses of affected individuals to the same etiological agent.

Capillary Resistance and the Corticoids

1958 ◽  
Vol 192 (3) ◽  
pp. 603-608 ◽  
Author(s):  
Jenö Kramár ◽  
Victor E. Levine ◽  
V. William Meyers ◽  
Robert N. Sass
Keyword(s):  
Plasma Concentration ◽  
Direct Relationship ◽  
The Other ◽  
Resistance Level ◽  
Adrenocortical Activity ◽  
Capillary Stress ◽  
Capillary Resistance ◽  
Relationship Of ◽  
The Relationship ◽  
Capillary Response

In an attempt to elucidate further the relationship of capillary resistance to the adrenal corticosteroids, capillary resistance was studied in connection with the plasma concentration and excretion of the 17, 21-dihydroxycorticosteroids in three groups of experiments. The actual concentration of these steroids in the plasma of nonstressed subjects failed to show any correlation with the actual capillary resistance level. The stress-induced increase in capillary resistance (capillary stress response) was accompanied by simultaneous changes in the plasma concentration or excretion of these corticosteroids in some experiments. In other experiments, on the other hand, plasma concentration and elimination of the corticosteroids did not change despite marked capillary response. This failure to demonstrate a consistent correlation between capillary resistance and plasma concentration and urinary excretion of the 17, 21-dihydroxycorticosteroids militates against a direct relationship of capillary resistance to adrenocortical activity and suggests the existence of another factor as playing a role in the capillary resistance-corticosteroid relationship.

scholarly journals A Guttate Psoriasis That Tends to Spare Three Tattoos: A Macrophage Liaison

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Panagiota Spyridonos ◽  
Vasiliki Zampeli ◽  
Sophia-Nefeli Rapti ◽  
Ioannis D. Bassukas
Keyword(s):  
Spatial Distribution ◽  
Case Report ◽  
Clinical Studies ◽  
Coefficients Of Variation ◽  
Spatial Concordance ◽  
Guttate Psoriasis ◽  
Clinical Pictures ◽  
Relationship Of ◽  
The Relationship

Induction of new psoriasis sites was reported in only a small amount of psoriasis patients undergoing tattooing, despite the intuitive belief that tattoo trauma might awaken the disease due to the isomorphic phenomenon of Koebner. In this case report, we discuss a patient who presented with a remarkable sparing of his three tattoo sites during a guttate psoriasis flare-up that was unrelated to tattooing. The spatial concordance of tattoo and psoriasis lesions was analyzed on clinical pictures of tattoo sites taken during the psoriasis episode. For the quantification of the spatial distribution of the psoriasis lesions, Voronoi diagrams were generated, and coefficients of variation and the two-sample t-test were employed to compare the distributions of Voronoi patch sizes in different settings. Compared to skin areas without tattoos, a tattoo introduced a higher variation in the sizes of the Voronoi patches centered around psoriasis lesions. Based on our findings, we would like to discuss the possible role of macrophages as the key cellular link in the complex pathophysiologic relationship between tattooing/tattoo and psoriasis. Taking into account the relationship of autophagy and psoriasis lesions, we propose the hypothesis that tattoos represent a “psoriasis-hostile” tissue environment pertained by a population of LAP active M2-polarized macrophages. Further clinical studies of the relationship of psoriasis lesions to the tattooed skin are needed and may provide important insights into the role of macrophages in the pathogenesis of psoriasis.

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