Pre-clinical study of 21 approved drugs in the mdx mouse

2011 ◽  
Vol 21 (5) ◽  
pp. 313-327 ◽  
Author(s):  
Maïté Carre-Pierrat ◽  
Aude Lafoux ◽  
Guillaume Tanniou ◽  
Lucie Chambonnier ◽  
Alexandra Divet ◽  
...  
Keyword(s):  
Clinical Study ◽  
Mdx Mouse ◽  
Approved Drugs

scholarly journals Pharmacologic Activities of Plant-Derived Natural Products on Respiratory Diseases and Inflammations

2021 ◽  
Vol 2021 ◽  
pp. 1-23
Author(s):  
Deepak Timalsina ◽  
Krishna Prasad Pokhrel ◽  
Deepti Bhusal
Keyword(s):  
Natural Products ◽  
Clinical Study ◽  
Respiratory Diseases ◽  
Oxygen Deficiency ◽  
Respiratory Complications ◽  
Detailed Mechanism ◽  
Respiratory Inflammation ◽  
Approved Drugs ◽  
Scientific Validation ◽  
Review Current

Respiratory inflammation is caused by an air-mediated disease induced by polluted air, smoke, bacteria, and viruses. The COVID-19 pandemic is also a kind of respiratory disease, induced by a virus causing a serious effect on the lungs, bronchioles, and pharynges that results in oxygen deficiency. Extensive research has been conducted to find out the potent natural products that help to prevent, treat, and manage respiratory diseases. Traditionally, wider floras were reported to be used, such as Morus alba, Artemisia indica, Azadirachta indica, Calotropis gigantea, but only some of the potent compounds from some of the plants have been scientifically validated. Plant-derived natural products such as colchicine, zingerone, forsythiaside A, mangiferin, glycyrrhizin, curcumin, and many other compounds are found to have a promising effect on treating and managing respiratory inflammation. In this review, current clinically approved drugs along with the efficacy and side effects have been studied. The study also focuses on the traditional uses of medicinal plants on reducing respiratory complications and their bioactive phytoconstituents. The pharmacological evidence of lowering respiratory complications by plant-derived natural products has been critically studied with detailed mechanism and action. However, the scientific validation of such compounds requires clinical study and evidence on animal and human models to replace modern commercial medicine.

Fine structure of early degenerating myofibers in the tibialis anterior of young ‘MDX’ mouse

1988 ◽  
Vol 46 ◽  
pp. 322-323
Author(s):  
H.D. Geissinger ◽  
C.K. McDonald-Taylor
Keyword(s):  
Fine Structure ◽  
Muscle Regeneration ◽  
Tibialis Anterior ◽  
Genetic Defect ◽  
Mdx Mouse ◽  
Mdx Mice ◽  
Histopathological Changes ◽  
Electron Microscopic ◽  
Dystrophic Mouse ◽  
Preliminary Study

A new strain of mice, which had arisen by mutation from a dystrophic mouse colony was designated ‘mdx’, because the genetic defect, which manifests itself in brief periods of muscle destruction followed by episodes of muscle regeneration appears to be X-linked. Further studies of histopathological changes in muscle from ‘mdx’ mice at the light microscopic or electron microscopic levels have been published, but only one preliminary study has been on the tibialis anterior (TA) of ‘mdx’ mice less than four weeks old. Lesions in the ‘mdx’ mice vary between different muscles, and centronucleation of fibers in all muscles studied so far appears to be especially prominent in older mice. Lesions in young ‘mdx’ mice have not been studied extensively, and the results appear to be at variance with one another. The degenerative and regenerative aspects of the lesions in the TA of 23 to 26-day-old ‘mdx’ mice appear to vary quantitatively.

A Clinical Study of Twenty-seven Children Exhibiting Functional Hearing Loss

1981 ◽  
Vol 12 (1) ◽  
pp. 26-35 ◽  
Author(s):  
Donald L. McCanna ◽  
Giacinto DeLapa
Keyword(s):  
Hearing Loss ◽  
Clinical Study ◽  
Early Identification ◽  
Behavioral Responses ◽  
Upper Elementary ◽  
Elementary Grades ◽  
Ability Level ◽  
Hearing Problem

This report reviews 27 cases of children exhibiting functional hearing loss. The study reveals that most students were in the upper elementary grades and were predominantly females. These subjects were functioning below their ability level in school and were usually in conflict with school, home, or peers. Tests used were selected on the basis of their helping to provide early identification. The subjects' oral and behavioral responses are presented, as well as ways of resolving the hearing problem. Some helpful counseling techniques are also presented.

Entergastrone Parenterally in the Treatment of Peptic Ulcer: A Controlled Clinical Study

1951 ◽  
Vol 17 (1) ◽  
pp. 35-38 ◽  
Author(s):  
Frank C. Bone ◽  
Chester Cassel ◽  
Julian M. Ruffin ◽  
Robert J. Reeves
Keyword(s):  
Peptic Ulcer ◽  
Clinical Study ◽  
Controlled Clinical Study

Clinical Study of Five-Year Survivors After Surgery for Gastric Carcinoma

1961 ◽  
Vol 40 (2) ◽  
pp. 188-196 ◽  
Author(s):  
Charles H. Brown ◽  
Mauro Merlo ◽  
John B. Hazard
Keyword(s):  
Clinical Study ◽  
Gastric Carcinoma

589: Tissue Engineered Tubularized Urethra for Surgical Reconstruction: A Pre-Clinical Study

2007 ◽  
Vol 177 (4S) ◽  
pp. 197-197 ◽  
Author(s):  
Hazem O. Orabi ◽  
Tamer A. Aboushwareb ◽  
Yuan Yuan Zhang ◽  
James J. Yoo ◽  
Anthony Atala
Keyword(s):  
Clinical Study ◽  
Surgical Reconstruction

A photoelastic clinical study of the static load distributionat the stump/socket interface of PTB sockets

2005 ◽  
Vol 29 (3) ◽  
pp. 291-302 ◽  
Author(s):  
P. Sewell ◽  
J. Vinney ◽  
S. Noroozi ◽  
R. Amali ◽  
S. Andrews
Keyword(s):  
Clinical Study ◽  
Static Load ◽  
Socket Interface
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