scholarly journals Exercise training restores eNOS activation in the perivascular adipose tissue of obese rats: Impact on vascular function

Nitric Oxide ◽  
2019 ◽  
Vol 86 ◽  
pp. 63-67 ◽  
Author(s):  
Cindy Meziat ◽  
Doria Boulghobra ◽  
Eva Strock ◽  
Sylvain Battault ◽  
Isabelle Bornard ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Exercise Training ◽  
Vascular Function ◽  
Perivascular Adipose Tissue ◽  
Obese Rats

scholarly journals Perivascular adipose tissue modulates vascular function in the human internal thoracic artery

2005 ◽  
Vol 130 (4) ◽  
pp. 1130-1136 ◽  
Author(s):  
Yu-Jing Gao ◽  
Zhao-hua Zeng ◽  
Kevin Teoh ◽  
Arya M. Sharma ◽  
Labib Abouzahr ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Vascular Function ◽  
Internal Thoracic Artery ◽  
Perivascular Adipose Tissue

scholarly journals Effects of Exercise Training on Brown Adipose Tissue Thermogenesis in Ovariectomized Obese Rats.

1989 ◽  
Vol 36 (3) ◽  
pp. 403-408 ◽  
Author(s):  
KEIJI YOSHIOKA ◽  
TOSHIHIDE YOSHIDA ◽  
YASUO WAKABAYASHI ◽  
HITOSHI NISHIOKA ◽  
MOTOHARU KONDO
Keyword(s):  
Adipose Tissue ◽  
Exercise Training ◽  
Brown Adipose Tissue ◽  
Brown Adipose ◽  
Obese Rats ◽  
Brown Adipose Tissue Thermogenesis

scholarly journals Maternal separation enhances anticontractile perivascular adipose tissue function in male rats on a high-fat diet

2018 ◽  
Vol 315 (6) ◽  
pp. R1085-R1095 ◽  
Author(s):  
Analia S. Loria ◽  
Frank T. Spradley ◽  
Ijeoma E. Obi ◽  
Bryan K. Becker ◽  
Carmen De Miguel ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
High Fat Diet ◽  
Life Stress ◽  
Vascular Function ◽  
Maternal Separation ◽  
Male Rats ◽  
Protective Effects ◽  
Ang Ii ◽  
High Fat ◽  
Perivascular Adipose Tissue

Clinical studies have shown that obesity negatively impacts large arteries’ function. We reported that rats exposed to maternal separation (MatSep), a model of early life stress, display enhanced angiotensin II (ANG II)-induced vasoconstriction in aortic rings cleaned of perivascular adipose tissue (PVAT) under normal diet (ND) conditions. We hypothesized that exposure to MatSep promotes a greater loss of PVAT-mediated protective effects on vascular function and loss of blood pressure (BP) rhythm in rats fed a high-fat diet (HFD) when compared with controls. MatSep was performed in male Wistar-Kyoto rats from days 2 to 14 of life. Normally reared littermates served as controls. On ND, aortic rings from MatSep rats with PVAT removed showed increased ANG II-mediated vasoconstriction versus controls; however, rings from MatSep rats with intact PVAT displayed blunted constriction. This effect was exacerbated by an HFD in both groups; however, the anticontractile effect of PVAT was greater in MatSep rats. Acetylcholine-induced relaxation was similar in MatSep and control rats fed an ND, regardless of the presence of PVAT. HFD impaired aortic relaxation in rings without PVAT from MatSep rats, whereas the presence of PVAT improved relaxation in both groups. On an HFD, immunolocalization of vascular smooth muscle-derived ANG-(1–7) and PVAT-derived adiponectin abundances were increased in MatSep. In rats fed an HFD, 24-h BP and BP rhythms were similar between groups. In summary, MatSep enhanced the ability of PVAT to blunt the heightened ANG II-induced vasoconstriction and endothelial dysfunction in rats fed an HFD. This protective effect may be mediated via the upregulation of vasoprotective factors within the adipovascular axis.

Perivascular adipose tissue in vascular function

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Edwyn O. Cruz-López ◽  
Estrellita Uijl ◽  
A.H. Jan Danser
Keyword(s):  
Adipose Tissue ◽  
Vascular Function ◽  
Perivascular Adipose Tissue

scholarly journals Resistin Mediates Sex-Dependent Effects of Perivascular Adipose Tissue on Vascular Function in the Shrsp

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Heather Yvonne Small ◽  
Sarah McNeilly ◽  
Sheon Mary ◽  
Adam Marcus Sheikh ◽  
Christian Delles
Keyword(s):  
Adipose Tissue ◽  
Vascular Function ◽  
Perivascular Adipose Tissue

scholarly journals Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation

2011 ◽  
Vol 301 (4) ◽  
pp. H1425-H1437 ◽  
Author(s):  
Timothy P. Fitzgibbons ◽  
Sophia Kogan ◽  
Myriam Aouadi ◽  
Greg M. Hendricks ◽  
Juerg Straubhaar ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Vascular Function ◽  
Immune Cell ◽  
Expression Profiles ◽  
Immunohistochemical Analysis ◽  
Macrophage Infiltration ◽  
Interscapular Brown Adipose Tissue ◽  
Perivascular Adipose Tissue ◽  
The Metabolic Syndrome ◽  
Brown Adipose

Thoracic perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and the metabolic syndrome. Surprisingly, PVAT has been reported to share characteristics of both brown and white adipose, but a detailed direct comparison to interscapular brown adipose tissue (BAT) has not been performed. Here we show by full genome DNA microarray analysis that global gene expression profiles of PVAT are virtually identical to BAT, with equally high expression of Ucp-1, Cidea, and other genes known to be uniquely or very highly expressed in BAT. PVAT and BAT also displayed nearly identical phenotypes upon immunohistochemical analysis, and electron microscopy confirmed that PVAT contained multilocular lipid droplets and abundant mitochondria. Compared with white adipose tissue (WAT), PVAT and BAT from C57BL6/J mice fed a high-fat diet for 13 wk had markedly lower expression of immune cell-enriched mRNAs, suggesting resistance to obesity-induced inflammation. Indeed, staining of BAT and PVAT for macrophage markers (F4/80 and CD68) in obese mice showed virtually no macrophage infiltration, and FACS analysis of BAT confirmed the presence of very few CD11b+/CD11c+ macrophages in BAT (1.0%) compared with WAT (31%). In summary, murine PVAT from the thoracic aorta is virtually identical to interscapular BAT, is resistant to diet-induced macrophage infiltration, and thus may play an important role in protecting the vascular bed from inflammatory stress.

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